DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zld and MESR4

DIOPT Version :9

Sequence 1:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster

Alignment Length:	1674	Identity:	292/1674 - (17%)
Similarity:	503/1674 - (30%)	Gaps:	566/1674 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 GLGGIPTASSAQEEAGSAPSAVSTTTAVAMSPRVVSSSSPTSTSSHLQLGSSSGQTPGSPGGAAG 274
            |..|..:.:.::|..|:..:|........:...:..:.....:..|.|..::.|...|.|
  Fly    19 GEAGRGSETGSEEGTGAGAAAGEEDDIEELHYVLDQAKEENESHQHGQNNNAKGNEDGKP----- 78

  Fly   275 SAGCKLQCKK------------CGILTTNESEL--QEHIANVHGESPYGSSGYASSPYIKEEMPT 325
                    ||            .|...|.|.|.  .|..|.....:....:..|....:.....|
  Fly    79 --------KKNDDVIDVTMANGQGFKDTPEEETTGTEETAETEETAETEEAEQAEESLLNSRKST 135

  Fly   326 PQPPGVGS---ATANPGELLDLDSQKMV--------------YHQQLLQQQQQQHDVVAGLPLGA 373
            ..|..:|:   .|.:|.:  ||..|::|              .::|.|...:.:.:|
  Fly   136 DTPVDLGANCLTTGSPSK--DLVKQELVEDKSEELKEPTSISLNEQFLDDIELKTEV-------- 190

  Fly   374 LPDPLHSMQSMQQRALHSWEQQPQQTVASVEGLPPYMQQGLGVGLGVGVD-KSPYYSPKQS---- 433
             .|...|:.......|...|:||.::              ||......:| |..::.||:|
  Fly   191 -EDKSDSLSETHMEFLTDSEEQPSES--------------LGANHESEIDEKVDHFQPKESDSNE 240

  Fly   434 ---PYHQSTGVGGATLIKQEYGGHGLIKSEYPDSQHYVDKSF-------------------DPTA 476
               .|.||......:.|::......:|..| .||:. .||.|                   ..|:
  Fly   241 VEDKYFQSANEDSESEIEETVYTPPVINLE-TDSES-GDKEFISIKDNESPVLEIEGGTEKSQTS 303

  Fly   477 GGAGGAELCASVATSPAEFPSTTT---GGPGQEGAAGAAPGGGYRGFEPPSSSSVLPANSLTAKA 538
            |....|::....:|:|.|...||:   |.|..||                  |..|.:.|||...
  Fly   304 GDLYQADVGEYASTAPPEVDETTSQTIGVPSLEG------------------SDTLDSPSLTMDV 350

  Fly   539 ATWKSNEARRPKTYNCTAC--NKWFTSSGHLKRHYNTTL--------HK------------NAVK 581
            ....|.:...|......:.  ::..:.|..||.|....:        ||            ..|:
  Fly   351 DLPCSEDGAPPNVIKIESDMEDEAHSDSVKLKEHTVEVVPLIKLNGAHKALKEEKLEDGEVEEVE 415

  Fly   582 SSGQ--PDPATLPISAHH-------------HPARDPVTKPSRRGNAAAAAAAAAAAASASGQGQ 631
            ..|:  .||....:..:|             ..:..|:..|.....:.:.::.::..:|||
  Fly   416 DPGEELEDPKEQSVITNHTGNNTKEEDTTASQVSALPLILPVGTTRSRSISSRSSTVSSAS---- 476

  Fly   632 QQQPPI----PPPPANVPPPEPPRSPPDYGGGGGLGVGAMGGAAMSQYSASPSPTQQQQHHLNHH 692
              ||.:    |....|..||                  |:..:...:.|.|.|.:|.::    ..
  Fly   477 --QPHLVIDHPESEHNAKPP------------------ALKLSLKRRRSKSSSVSQPEK----QT 517

  Fly   693 QQQANGYANGTANGYGYMQQQVQSTTNASPQHASNNNSN-------NQQ---QQQQQQQHHQQQM 747
            :.:|.|:.:      ..:.|::||.:|..|...|..:..       |.|   ::.|:...||.|.
  Fly   518 KVEAGGFVS------SLLLQRLQSNSNVIPPAISTESQQVLSCAKCNLQFDFERFQELNKHQAQC 576

  Fly   748 PQHHNSVLNGHPNGLAGPSAPHNNNTTQMPSSQMRGLLNETTTTPPPTTTTRAPQITTTATTTTT 812
                              |...:.|::|:...|.|..              |..|..:
  Fly   577 ------------------SGIQSANSSQLSQKQERFF--------------RCSQCCS------- 602

  Fly   813 AATTVAIKSEQMEDSNHTHTH-------------THTHPN---------HSHSQDRSHSSSSSSS 855
                       :....|...|             .|.:|:         :.|..|:||.:
  Fly   603 -----------VHQCWHFFLHMREVHRRYICLYCNHVYPSVEKLSLHLENKHDIDQSHFA----- 651

  Fly   856 MATEEAEEQELRDQEQADDHL-----------------HQHQQASQQ---------YLLSARHYH 894
               ::|.:|:...:::| .||                 |...|..|.         :::..::..
  Fly   652 ---KDAWDQQQSKEDRA-RHLVCCTCQATFVQGSEFEDHDCSQLMQPCALCNQKGGHIIGCKNNK 712

  Fly   895 -------------SSTPNTLSSSNTNPSTPSSNSPHTIYRQEQQGTDF-----SRTTPPPQPL-- 939
                         ...|..:|........|....|..:.:|....:|.     :...|.|:|:
  Fly   713 RKPTKRRRKVRRPPEPPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVED 777

  Fly   940 PPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTST--------TPLATTITT---SMPDT 993
            ||...:|.:.:...||.  :|......:.:.:   |||.|        .|:...::.   .:|..
  Fly   778 PPAPPIPKLVVPKIMLR--VPKEFQKSVDAAL---SSTDTEDEELETAQPVEEAVSAPPEDLPFD 837

  Fly   994 MQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQQQQALILADSLPHSSS 1058
            ..||....:.:..:....|::.|.|. :|.:.|     .|..:.|...::|..:|:|::  |..:
  Fly   838 APPPPPPALSYDDSTSSKLNRVLAEL-ERTKLD-----IERTKADIITKKQSKIIMANA--HLEN 894

  Fly  1059 SPTSSSPPPTMPMP---------LTTITAPQ----LLPLQPPPPHIT----------------ST 1094
            .......||....|         ||...:|.    .|| :|||..||                ..
  Fly   895 VVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNLP-EPPPALITEFQGQPDAVRRNSLGSDC 958

  Fly  1095 MPMPPTMHMPIM---------------PPPPQCYQQ-------LQPLDPTMSYHTIIGSGPEAHT 1137
            |.|..:::.|.|               |.||....|       :|||.|.   ..|:.:||:.|
  Fly   959 MDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTADEPLAIQPLPPA---DGIMVAGPDTH- 1019

  Fly  1138 GTAGGGYSNQITTSDGQILQLMPTSLFAPYAPL---SPYSVA-----AQRSPQEGDLPPVHTLTT 1194
                        |.|.|:.:.:.......:..|   |.||:.     |:|         :.....
  Fly  1020 ------------TVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARR---------IAVNVK 1063

  Fly  1195 ALHAHQQGGQQEAQTPTLTVLSTPYSPTVSSSRAT--PALE---MDMATLMQHHQDYEMEQYQMQ 1254
            .|..|..|..:...|.........|:.|:.:...:  |.||   |:.|:.........:|.:..:
  Fly  1064 QLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSFLPNLENEYMNAASCCSLENGKYVEPFNER 1128

  Fly  1255 HQQLDQMQ----QHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTS 1315
            ..:....:    .|::...|.::..|.::.|..|.|                      ::..|.|
  Fly  1129 IYECFTCRFVTSTHKELYTHNRRLHIKSNITCVMCQ----------------------TNFYSYS 1171

  Fly  1316 PHSTTLPSGRI---------KCLECDKEFTKNCY-LTQHNKSFHSGEYPFRCQKCGKRFQSEDVY 1370
            .....:..|.:         :|..||.....:.: |..|.:..|..     |..|.:..||:...
  Fly  1172 EILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRLMVHLRKQHQA-----CDICLEDCQSQSKL 1231

  Fly  1371 TTHLGRHRTQDKPHKCELCPKQFHHKTDLRRHVEAIH----TGLKQ----------HMC-----D 1416
            ::|:.:|:..   |.|..|...:.:|.|:.:|:...|    .|.||          |.|     .
  Fly  1232 SSHVWKHKLL---HLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEF 1293

  Fly  1417 ICEK-GFCRKDHLRKHLETHNRPRVVGKKSAAAAAAAAAAAAVTATAGLGGAPAAGSIKAAFARS 1480
            .||: ||.....:  :||.|.|......:.|..                    ..|..:...:|.
  Fly  1294 PCEQCGFVFSKAI--YLEVHQRMHTGDFRYACT--------------------EEGCEEKFVSRK 1336

  Fly  1481 LTVTAVSSEPGAGVAIPSAPATATCAPVSVSASALVQAVNPSLTSGLSLKRHIDDVAVDDDSLLE 1545
            |.:...||.                     .|..|.|||:...|:..:....::|:..:    ||
  Fly  1337 LLLKHASSH---------------------VAKELPQAVSVEQTADAAPTEKLEDIKEE----LE 1376

  Fly  1546 EDEDEMEMEMEMDMLEEEDEEEEELGDHHMIIKSEYVQEEFQMIEKSIE 1594
            |.|||.|.....:.|..|.....|...          :||...|:.|||
  Fly  1377 EGEDEKEGAHNQEKLLSESLTNNETPK----------KEESDRIDNSIE 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983	4/34 (12%)
		LIM	1328..1389	CDD:259829	14/61 (23%)
		C2H2 Zn finger	1328..1349	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1357..1377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1386..1407	CDD:275368	5/20 (25%)
		zf-H2C2_2	1398..1422	CDD:290200	10/43 (23%)
		zf-C2H2	1413..1435	CDD:278523	8/27 (30%)
		C2H2 Zn finger	1415..1435	CDD:275368	7/25 (28%)
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	3/15 (20%)
		C2H2 Zn finger	1295..1315	CDD:275370	8/21 (38%)
		C2H2 Zn finger	1323..1341	CDD:275370	3/37 (8%)
		PHD_ING	2110..2156	CDD:276980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100