DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zld and rgr

DIOPT Version :9

Sequence 1:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	166/927 - (17%)
Similarity:	281/927 - (30%)	Gaps:	347/927 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 PPIPPPPANV----------------------------------PPPEPPRSPPDYGGGGGLGVG 665
            ||.|||.|::                                  |||.||...|
  Fly   146 PPSPPPSADISVDELPGSSPQSFDLDPFAVLHEVVTMTPPTPIAPPPGPPTPNP----------- 199

  Fly   666 AMGGAAMSQYSASPSPTQQQQHHLNHHQQQANGYANGTANGYGYMQQQVQ------STTNASP-- 722
                    ..:|:|:|..:                        |..::|:      |:|..:|
  Fly   200 --------TPTATPAPLPR------------------------YETRRVRQRLCTISSTTINPGQ 232

  Fly   723 -----QHASNNNSNNQQQQQQQQQHHQQQMPQHHNSVLNGHPNGLAGPSAPHNNNTTQMPSSQMR 782
                 |..|....|.....|::.:..|.:.|:          :|.....|...:..|: |:.|..
  Fly   233 DRLAGQRLSRREPNTGNAMQRKLRQSQNEQPK----------DGAVDEVAVEEHKGTE-PTGQPE 286

  Fly   783 GLLNETTTTPPPTTTTRAPQITTTATTTTTAATTVAIKSEQMEDSNH--------THTHTH---- 835
            ....|  .|||.|..|..|  .|:.|::|.:......||.:..:.||        .:..|.
  Fly   287 KSAME--LTPPATPPTPLP--PTSPTSSTASCADFQSKSRRELERNHEFVGCLLREYERTEKLWN 347

  Fly   836 -THPNHSHSQDRS-------------HSSSSSSSMATEEAEEQELRDQEQAD------------- 873
             .||::.::..||             |...|.:.:.   |..:|||.:.:.:
  Fly   348 PRHPDYKYNAKRSAYGDLAGPLESICHRQLSGAEIF---AVLKELRCRYRRELKKVNALGGKYKS 409

  Fly   874 --------DHLH---QHQQASQQYLLSARHYHSSTPNTLSSSNTNPSTPSSNSPHTIY------- 920
                    |.|.   ::::|.::..:|    :.||.:..|......|...|:..|.:.
  Fly   410 RLWYFERMDFLRCVIENRRAEREAKIS----NESTESEKSCETDADSCGKSSLYHEVLSFILDAF 470

  Fly   921 -RQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTSTTPLAT 984
             |||                   .:..|...||                          ||...|
  Fly   471 KRQE-------------------CLWNPQHYDY--------------------------TTCCKT 490

  Fly   985 TITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQQQQALIL 1049
            .:                  ::.:...|.::|..:...:|..:     |:.:|..:.:::..:::
  Fly   491 EL------------------FRDISVQLQEELNYELSGEECCN-----EIQKLRTRYRKELRMVI 532

  Fly  1050 ADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQPPPPHITSTMPMPPTMHMPIMPPPPQCYQ 1114
                                                               .|..:..|...||.
  Fly   533 ---------------------------------------------------KHKGLYLPKLWCYD 546

  Fly  1115 QLQPLDPTMSYHTIIGSGPEAHTGTAGGGYSNQIT--------TSDGQILQLMPTSLFAPYAPL- 1170
            :::.|.|.:...  |.:......|..|   |||.|        ..|....||....::..|:.|
  Fly   547 EMEFLQPILQEQ--IFNKISKKIGVVG---SNQKTKFIDASSIRFDNTEKQLQFVEIYHNYSALW 606

  Fly  1171 ----SPYSVAAQRSPQEGDLPPVHTLTTALHAHQQGGQQEAQTPTLTVLSTPYSP------TVS- 1224
                ..:.....||...|.:  :..:.|..|......|.|   .||..|...:|.      |.|
  Fly   607 DVDHPDFRSNTYRSQALGQM--LDEINTTFHTSYTAEQLE---KTLFNLRKEFSAQKRKILTESE 666

  Fly  1225 SSRATPALEMDMATLM-QHHQDYEMEQYQMQHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQP 1288
            .|.:.|.|...:|..: |:...:..:......:..||.:.|:..  |...|..:........|.|
  Fly   667 DSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSA--HDGTQPFICTLCGKGFQMP 729

  Fly  1289 LAKKRRGGNATPSTTKRRRNSSVGSTSPHSTTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEY 1353
            .       |.|....:.||:      .|:|         |.:|||.|..:..:..|.:: |:||.
  Fly   730 C-------NLTVHIRRHRRD------FPYS---------CEQCDKRFATSTEVAIHLRT-HTGER 771

  Fly  1354 PFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELCPKQFHHKTDLRRHVEAIHTGLKQHMCDIC 1418
            |:.|..|||.|::...:..|..||..|...| |.:|.|.|:.|.....|:.: |..:::|:|.:|
  Fly   772 PYICDLCGKSFKTWSFFDIHRRRHLNQSTFH-CPICAKGFYEKNRFTDHMNS-HWAIRKHLCTVC 834

  Fly  1419 EKGFCRKDHLRKHLETH 1435
            .|.|....:|:||.|.|
  Fly   835 GKTFTTYGNLKKHTELH 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	21/60 (35%)
		C2H2 Zn finger	1328..1349	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1357..1377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1386..1407	CDD:275368	6/20 (30%)
		zf-H2C2_2	1398..1422	CDD:290200	6/23 (26%)
		zf-C2H2	1413..1435	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1415..1435	CDD:275368	8/19 (42%)
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	12/87 (14%)
		MADF_DNA_bdg	465..551	CDD:287510	18/204 (9%)
		MADF_DNA_bdg	595..682	CDD:287510	19/91 (21%)
		C2H2 Zn finger	691..711	CDD:275368	3/21 (14%)
		C2H2 Zn finger	719..739	CDD:275368	4/26 (15%)
		zf-H2C2_2	731..756	CDD:290200	11/39 (28%)
		COG5048	742..>824	CDD:227381	28/99 (28%)
		C2H2 Zn finger	747..767	CDD:275368	6/20 (30%)
		zf-H2C2_2	763..784	CDD:290200	10/21 (48%)
		C2H2 Zn finger	775..795	CDD:275368	6/19 (32%)
		C2H2 Zn finger	803..818	CDD:275368	5/14 (36%)
		C2H2 Zn finger	831..851	CDD:275368	8/19 (42%)
		C2H2 Zn finger	859..877	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930