DRSC/TRiP Functional Genomics Resources

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Protein Alignment zld and HIC2

DIOPT Version :10

Sequence 1:NP_608356.1 Gene:zld / 32994 FlyBaseID:FBgn0259789 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_055909.2 Gene:HIC2 / 23119 HGNCID:18595 Length:615 Species:Homo sapiens


Alignment Length:770 Identity:139/770 - (18%)
Similarity:215/770 - (27%) Gaps:292/770 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   752 NSVLNGHPNGLAGPS------APHNN----NTTQMPSSQMRGLLNETTTTP-PPTTTTRAPQITT 805
            ||:...|.|.||..|      ..|:|    :|..:.|:..:.:|:...|.. .|:.....|..:|
Human    54 NSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFST 118

  Fly   806 --TATTTTTAATTVAIKSEQMEDSNHTHTHTHTHPNHSHSQDRSHSSSSSSSMATEEAEEQELRD 868
              ||.:........|:...:::.:..................||...|::|.:   :|..|.|.|
Human   119 LLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVI---QARYQGLVD 180

  Fly   869 QEQ---ADDHLHQHQQASQQYLLSARHYHSSTPNTLS------------------SSNTNPSTPS 912
            ..:   |...|.|.:.:..:..|.     .|..:::.                  ||:||.|:..
Human   181 GRKGAHAPQELPQAKGSDDELFLG-----GSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGG 240

  Fly   913 SNSPHTIYRQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSST 977
            .        :::.|.|.|:.:||         |||..            |.|.|...:..|.|.:
Human   241 C--------EQELGLDLSKKSPP---------LPPAT------------PGPHLTPDDAAQLSDS 276

  Fly   978 STTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQ 1042
                                                     ||                      
Human   277 -----------------------------------------QH---------------------- 278

  Fly  1043 QQQALILADSLPHSSSSPTSSSPP-------------PTMPMPLTTITAPQLLPLQPPPPHITST 1094
                          .|.|.:|:||             |..||.|.......|..|:.|     ..
Human   279 --------------GSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAP-----GG 324

  Fly  1095 MPMPPTMHM----------PIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAH-TGTAGGGYSNQI 1148
            .|.....|.          |:...|   :::.:             :||:.. .|..|.|..:::
Human   325 QPRKSLRHSTRKKEWGKKEPVAGSP---FERRE-------------AGPKGPCPGEEGEGVGDRV 373

  Fly  1149 TTSDGQILQLMPTSLFAPYA-PLSPYSV--------------AAQRSPQEGDLPPVHTLTTALHA 1198
                       |..:.|..| |..||..              |::.|.|.|              
Human   374 -----------PNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSG-------------- 413

  Fly  1199 HQQGGQQEAQTPTLTVLSTPYSPTVSSSRATPALEMDMATLMQHHQDYEMEQY----------QM 1253
             .:||...|.                            |..|...:.||...|          ..
Human   414 -SEGGSGHAS----------------------------AHYMYRQEGYETVSYGDNLYVCIPCAK 449

  Fly  1254 QHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTSPHS 1318
            .....:|:..|                .:|..::.|..|..|...|.|.........:.:.|...
Human   450 GFPSSEQLNAH----------------VETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAY 498

  Fly  1319 TTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKP 1383
            |..|. ..||..|:|.:.....|.||.|: |....||.|..|||.|......|.|:..|... ||
Human   499 TAEPR-PFKCSVCEKTYKDPATLRQHEKT-HWLTRPFPCNICGKMFTQRGTMTRHMRSHLGL-KP 560

  Fly  1384 HKCELCPKQFHHKTDLRRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETHNRP 1438
            ..|:.|..:|..:..|..|:. :|:|.|.:.|.:|...|.::.:|..||..|..|
Human   561 FACDECGMRFTRQYRLTEHMR-VHSGEKPYECQLCGGKFTQQRNLISHLRMHTSP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zldNP_608356.1 zf-C2H2_jaz 552..577 CDD:432381
SUF4-like 1325..>1366 CDD:411020 16/40 (40%)
C2H2 Zn finger 1328..1349 CDD:411020 7/20 (35%)
C2H2 Zn finger 1328..1349 CDD:275368 7/20 (35%)
C2H2 Zn finger 1357..1377 CDD:275368 7/19 (37%)
C2H2 Zn finger 1386..1407 CDD:275368 5/20 (25%)
zf-C2H2 1413..1435 CDD:395048 6/21 (29%)
C2H2 Zn finger 1415..1435 CDD:275368 6/19 (32%)
HIC2NP_055909.2 BTB_POZ_ZBTB30_HIC2 25..144 CDD:349643 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..167 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..208 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..421 53/344 (15%)
Binding to CtBP 246..250 2/3 (67%)
C2H2 Zn finger 444..464 CDD:275368 2/35 (6%)
SUF4-like 503..>552 CDD:411020 17/50 (34%)
C2H2 Zn finger 507..527 CDD:411020 7/20 (35%)
C2H2 Zn finger 507..527 CDD:275368 7/20 (35%)
zf-C2H2 533..555 CDD:395048 8/21 (38%)
C2H2 Zn finger 535..555 CDD:275368 7/19 (37%)
C2H2 Zn finger 535..552 CDD:411020 6/16 (38%)
COG5048 559..>613 CDD:227381 17/54 (31%)
C2H2 Zn finger 563..583 CDD:275368 5/20 (25%)
zf-H2C2_2 575..600 CDD:463886 8/25 (32%)
C2H2 Zn finger 591..611 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

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