DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zld and ZNF114

DIOPT Version :9

Sequence 1:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001318027.1	Gene:	ZNF114 / 163071	HGNCID:	12894	Length:	463	Species:	Homo sapiens

Alignment Length:	166	Identity:	56/166 - (33%)
Similarity:	77/166 - (46%)	Gaps:	18/166 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1270 HQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTSPHSTTLPSGRIKCLECDKE 1334
            |..|.|:...:|.....|           |.:|:....||  ||...|.|...:.  ||.||.:.
Human   309 HAMQMQLYTAETNKKDCQ-----------TGATSANAPNS--GSHKSHCTGEKTH--KCPECGRA 358

  Fly  1335 FTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELCPKQFHHKTDL 1399
            |....:|.:|.| .|:||.|:.|.||||.|:.......||.:|..|.||::||.|.|.....:..
Human   359 FFYQSFLMRHMK-IHTGEKPYECGKCGKAFRYSLHLNKHLRKHVVQKKPYECEECGKVIRESSKY 422

  Fly  1400 RRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETH 1435
             .|:.: |||.|.:.|..|.|.|.:...|:|||:||
Human   423 -THIRS-HTGEKPYKCKTCGKDFAKSSGLKKHLKTH 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	25/60 (42%)
		C2H2 Zn finger	1328..1349	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1357..1377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1386..1407	CDD:275368	5/20 (25%)
		zf-H2C2_2	1398..1422	CDD:290200	8/23 (35%)
		zf-C2H2	1413..1435	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1415..1435	CDD:275368	8/19 (42%)
ZNF114	NP_001318027.1	KRAB	52..111	CDD:214630
		KRAB	52..91	CDD:279668
		zf-C2H2	350..372	CDD:278523	8/24 (33%)
		C2H2 Zn finger	352..372	CDD:275368	7/20 (35%)
		zf-H2C2_2	365..389	CDD:290200	13/24 (54%)
		C2H2 Zn finger	380..428	CDD:275368	17/49 (35%)
		Ribosomal_L37ae	388..>445	CDD:302811	19/58 (33%)
		zf-H2C2_2	423..444	CDD:290200	8/21 (38%)
		zf-C2H2	434..456	CDD:278523	8/21 (38%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11783
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950