DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12702 and CIP2A

DIOPT Version :9

Sequence 1:NP_001259735.1 Gene:CG12702 / 32993 FlyBaseID:FBgn0031070 Length:870 Species:Drosophila melanogaster
Sequence 2:NP_065941.2 Gene:CIP2A / 57650 HGNCID:29302 Length:905 Species:Homo sapiens


Alignment Length:978 Identity:195/978 - (19%)
Similarity:374/978 - (38%) Gaps:263/978 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 VREFRMRVACFQVQRSEESLVYVQRSVALLGTKVLPAHFAPTPGNLELARFYVD--------LYA 93
            ::...:.|:.::..:||.:...:.|.:.::..:             :|.|.:..        |..
Human     7 LKSLLLTVSQYKAVKSEANATQLLRHLEVISGQ-------------KLTRLFTSNQILTSECLSC 58

  Fly    94 LMGALKNEGAEGDVLWACVGLVQHCSRNLEARQAVVEHFCFVPLLGVLIRHTKRTERVH-RLLVL 157
            |:..|::......::.:.:||:...:.::|.|..:...:....:|..::..:..|:.|. :.:.|
Human    59 LVELLEDPNISASLILSIIGLLSQLAVDIETRDCLQNTYNLNSVLAGVVCRSSHTDSVFLQCIQL 123

  Fly   158 LQDLTYGIKIAWE----EPFLAALIEHLVGIVLCTEDVSCTASGGSVRDDDDENTMLALSVLVNL 218
            ||.|||.:||.:.    :..:..||:|                   ::..:||..|..|.:|.||
Human   124 LQKLTYNVKIFYSGANIDELITFLIDH-------------------IQSSEDELKMPCLGLLANL 169

  Fly   219 CYKNFAVLFLFLRSVNISAFCRRIQNYGLLAYKMLIILSEDVYSFQQSELCTFLRLSFAGIEDCL 283
            |..|.:|........|:.:|.|.:  ..|||:..|.::   |::.   .:.:.|.|:....|...
Human   170 CRHNLSVQTHIKTLSNVKSFYRTL--ITLLAHSSLTVV---VFAL---SILSSLTLNEEVGEKLF 226

  Fly   284 KHWNVAQL-----------------RHIVDFLLDSQSHPGLHRAMLSHGHFCEDFEKLLDQIDTS 331
            ...|:.|.                 ::.||.|:|...:|.:...:..:.||.....::|..:   
Human   227 HARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLHQVLGLL--- 288

  Fly   332 NGMDVSQEETSKHQQISLGL--VFRLVSYILQMSEEAN--SCISLDAITPRLYEMVS--DWMS-- 388
            ||.|  .:.:||..::.|..  |.:|...:.||..|.:  ...:|.:.|..|...|:  .|:|  
Human   289 NGKD--PDSSSKVLELLLAFCSVTQLRHMLTQMMFEQSPPGSATLGSHTKCLEPTVALLRWLSQP 351

  Fly   389 ---SDQCGAAAIELI------------C-------TLL-------------------------RL 406
               |:.|...|:||.            |       |||                         |:
Human   352 LDGSENCSVLALELFKEIFEDVIDAANCSSADRFVTLLLPTILDQLQFTEQNLDEALTRKKCERI 416

  Fly   407 GKRAAVAEMIANDPS---HVAKLVASAERPDTDAGQVLATLRLLIALLQETKTNKVVL---SKIS 465
            .|...|...:..|.:   |:||              :|.|::....:.|:....|:.|   :|::
Human   417 AKAIEVLLTLCGDDTLKMHIAK--------------ILTTVKCTTLIEQQFTYGKIDLGFGTKVA 467

  Fly   466 ESYFDKILAAPLALVPQFLSTQSLAQCEVEKACFCLLLLVN-----VAGIAKKAYLDKCCTLLEQ 525
            :|...| |||.:.|.                    .|.|:|     |.|:....|     .:|:.
Human   468 DSELCK-LAADVILK--------------------TLDLINKLKPLVPGMEVSFY-----KILQD 506

  Fly   526 PQLQYCLARGMVSKNEALVAA----VLQIAQFEHFPKASVAKHVSAITSSPGGMMTKASAVGSDQ 586
            |:|...||..:.|.|...|.:    :|:.|....||...:.:.::|           .:|....:
Human   507 PRLITPLAFALTSDNREQVQSGLRILLEAAPLPDFPALVLGESIAA-----------NNAYRQQE 560

  Fly   587 VEQLRNLSSIFKANRIFTD---------KDMVQRVN--ALLDNI-GGIVSRNELASAPTSQVIEL 639
            .|.:........:|..|..         ||.|..:|  .|::.: .|:|.::::.....|.::::
Human   561 TEHIPRKMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEELIEKLQSGMVVKDQICDVRISDIMDV 625

  Fly   640 YNHRIESLNGTVASLQQRLE-------QAGE-------QLTIGTQQAHVQSAELERFQSSNFQL- 689
            |..::.:|....:.||..||       ||..       |.|....:|...::.|...:..|.:| 
Human   626 YEMKLSTLASKESRLQDLLETKALALAQADRLIAQHRCQRTQAETEARTLASMLREVERKNEELS 690

  Fly   690 ------LISQERLQTRCKDLKQQKVELKS---NMTILLKQLSENSVQLQANERRLTVKKSEIADL 745
                  .:..||.|:..:.|.|...:|:|   ...||.|...|   .||.||.  |.||::  ||
Human   691 VLLKAQQVESERAQSDIEHLFQHNRKLESVAEEHEILTKSYME---LLQRNES--TEKKNK--DL 748

  Fly   746 QKDCENLRSKLSAKSEELTKLEAHNKENISRI---DKLKKSMAAYEQDMTEKLRTIGERDRELAK 807
            |..|::|..::....:....|:..|:::|:::   ::.:|.:.....|...||..:.::.:...:
Human   749 QITCDSLNKQIETVKKLNESLKEQNEKSIAQLIEKEEQRKEVQNQLVDREHKLANLHQKTKVQEE 813

  Fly   808 TQKALEEQREACKKSEDL--------------ISVLETQLQERKAQIESLEMEQKET------ED 852
            ..|.|:::||..:::.|:              :|:..:.|:.:|||:|. .:|:||:      |:
Human   814 KIKTLQKEREDKEETIDILRKELSRTEQIRKELSIKASSLEVQKAQLEG-RLEEKESLVKLQQEE 877

  Fly   853 LRK 855
            |.|
Human   878 LNK 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12702NP_001259735.1 SHE3 633..827 CDD:293683 50/234 (21%)
TMF_DNA_bd 738..793 CDD:289127 12/57 (21%)
PRKG1_interact 787..>855 CDD:292521 19/87 (22%)
DUF4078 <834..870 CDD:290039 10/28 (36%)
CIP2ANP_065941.2 Required for interaction with PPP2R5C. /evidence=ECO:0000269|PubMed:28174209 159..245 21/93 (23%)
Required for homodimerization. /evidence=ECO:0000269|PubMed:28174209 388..558 41/220 (19%)
SMC_N <618..868 CDD:330553 57/257 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11204
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 55 1.000 Inparanoid score I5436
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59363
OrthoDB 1 1.010 - - D104936at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR23161
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.170

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