DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12702 and cip2a

DIOPT Version :9

Sequence 1:	NP_001259735.1	Gene:	CG12702 / 32993	FlyBaseID:	FBgn0031070	Length:	870	Species:	Drosophila melanogaster
Sequence 2:	NP_001107893.1	Gene:	cip2a / 560948	ZFINID:	ZDB-GENE-030131-6252	Length:	896	Species:	Danio rerio

Alignment Length:	953	Identity:	189/953 - (19%)
Similarity:	355/953 - (37%)	Gaps:	199/953 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LAIGYVREFRMRVACFQVQRSEESLVYVQRSVALLGTKVLPAHFAPTPGNLELARFYVDLYALMG 96
            |||...|..|..:...|:|:..|.:..::.:..|...:|||:..  ..|.:|:|......:||.|
Zfish    12 LAIRQYRNNRSALNASQLQKHIEDISGLKCAGVLFSGQVLPSEC--LSGLMEVAGDPNTSHALTG 74

  Fly    97 ALKNEGAEGDVLWACVGLVQHCSRNLEARQAVVEHFCFVPLLGVLI---RHTKRTERVHRLLVLL 158
            .:             :.|:...:.:.|.::|:...:.|...|..:|   |.|.....|.:.|.:|
Zfish    75 TI-------------ISLLAQFASDGETKEALHSSYNFTGTLAAIIHCNRSTPEEPLVLQCLNVL 126

  Fly   159 QDLTYGIKIAWEEPFLAALIEHLVGIVLCTEDVSCTASGGSVRDDDDENTMLALSVLVNLCYKNF 223
            |.|||.::..    ..|:.|..|:..::           ..|:..:|:.....|.::.|||..:.
Zfish   127 QRLTYNVRTL----HCASHIHELISFLM-----------QHVQSSNDDIVKACLGLVANLCRHDV 176

  Fly   224 AVLFLFLRSVNISAFCRRIQNYGLLAYKMLII------------LSEDVYS--FQQSELCTFLRL 274
            .|.........:.||.|.:.|:  |.:..|.:            |:|:|..  |....:....:|
Zfish   177 TVQAHIKSQSYVKAFYRALINF--LGHNCLTVVVFALSILSSLTLNEEVGQKLFNAKNIHQTFQL 239

  Fly   275 SFAGIEDCLKHWNVA-------QLRHIVDFLLDSQSHPGLHRAMLSHGHFCEDFEKLLDQIDTSN 332
            .|          |:.       ...:.||.|:|...:|.:...:..:.|......::|..:.:.:
Zfish   240 IF----------NITVNGDGTLTRNYAVDLLVDLLKNPKIADYLTKYKHLSVCLSEVLGLLHSKD 294

  Fly   333 GMDVSQEETSKHQQI-----SLGLVFRLVSYIL------QMSEEANSCISLDAITPRLYEMVSDW 386
                 .:..||..::     |:.::.:||...:      ::.......:......|.|  .:..|
Zfish   295 -----PDTASKVMELLVSLCSVPVLRKLVCETVLRPPAPRLQPGTRKGVQARGSEPSL--ALVHW 352

  Fly   387 MSS-----DQCGAAAIELICTLLRLGKRAAVAEMIANDPSHVAKLVASA----ERPDTDAGQVL- 441
            ::|     :||...|:.|:..|.   :.|..:.:.::..|.|..|:...    :.||:..|..|
Zfish   353 VTSPLDGPEQCYMQALSLLAELF---EEAIGSSLCSSAQSFVELLLQEVLVLLQSPDSTEGDQLL 414

  Fly   442 --------ATLRLLIALLQETKTNKVVLSKISE----SYFDKILAAPLALVPQFLSTQS--LAQC 492
                    ..:..|:.|..:.....:|..::|.    |..:.:|:....|.....||.|  |:|.
Zfish   415 KKHCLRAGRVVDFLLVLCGDDALRMLVSQRLSPEVCVSQVELLLSYSQDLTGSTCSTSSYQLSQL 479

  Fly   493 EVEKACFCLLLLVNVAGIAKKAYLD---KCCTLLEQPQLQYCLARGMVSKNEALVAAVLQI---- 550
            ..|.....|.|:.::    ::...|   ....:|:..::...|:..|.|.....|...|:|
Zfish   480 CAEAVLKTLELMSHL----RQTMPDMETSFYRILQDQRMVTPLSLAMTSNRREHVQLALRILFEA 540

  Fly   551 AQFEHFPKA----SVAKHVSAITSSPGGMMTKASAVGSDQVEQLRNLSSIFKANRIFTDKDMVQR 611
            |....||..    |:|.: :|.....|.:..:.|:...|    ...:|..|..............
Zfish   541 APLPDFPSVILGDSIAAN-NAYRQRDGELSIRRSSASED----ASFISKSFPTMHTEPSGSASHS 600

  Fly   612 VNALLDNI-GGIVSRNELASAPTSQVIELYNHRIESLNGTVASLQQRLEQAGEQLTIGTQQA--- 672
            :::|::.: .|:..:.::.....|::|::|..::.:|    ||.:.||:...|...:...||
Zfish   601 IDSLIEKLQNGVELQEKVKDVHMSEIIDVYEQKLSAL----ASKESRLQDLLEAKALALSQADRL 661

  Fly   673 ------------------------------------HVQSAELERFQSSNFQLLISQERLQTRCK 701
                                                :.|..|:||.:|.:.|||....|||.
Zfish   662 IAQYRCQRAQAEAEARKLASLLKDTERRKEDLQAELNDQLLEVERLKSDSQQLLQHNGRLQA--- 723

  Fly   702 DLKQQKVELKSNMTILLKQL--SENSVQ-LQANERRLTVKKSEIADLQKDCENLR-------SKL 756
             :..|...||.....||.:.  ||.::: |||....||   .:...|:|..|.||       ::|
Zfish   724 -VADQHQGLKGTYNQLLSRYDKSEGTLKDLQAAHISLT---QQAEGLRKTNEGLRLQQERTLAEL 784

  Fly   757 SAKSEELTKLEAHNKENISRIDKLKKSMAAYEQDMTEKLRTIGERDRELAKTQKALEEQREACKK 821
            :.|.:::..|:|...|..|.|..|:..:...|:.:.|....|....:||.||::|   :::...|
Zfish   785 AEKEQQIKGLKADVLEKDSNITGLQNELRRQEEQIKEMEENISILRKELNKTEQA---RKDTSIK 846

  Fly   822 SEDLISVLETQLQERKAQIESLEMEQKETEDLRKTIMSLMESK 864
            :    |.||.|..:.:|::|.:|.|..:...:...|.||...|
Zfish   847 A----SSLELQKSQLEAKLEKIEEELGKHTQMIAMIHSLSSGK 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12702	NP_001259735.1	SHE3	633..827	CDD:293683	56/242 (23%)
		TMF_DNA_bd	738..793	CDD:289127	14/61 (23%)
		PRKG1_interact	787..>855	CDD:292521	17/67 (25%)
		DUF4078	<834..870	CDD:290039	8/31 (26%)
cip2a	NP_001107893.1	COG1340	604..868	CDD:224259	65/281 (23%)
		RILP-like	616..752	CDD:304877	29/143 (20%)
		TMF_DNA_bd	794..865	CDD:289127	21/77 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59363
OrthoDB	1	1.010	-	-		D104936at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23161
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.120