DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12702 and myo-5

DIOPT Version :9

Sequence 1:	NP_001259735.1	Gene:	CG12702 / 32993	FlyBaseID:	FBgn0031070	Length:	870	Species:	Drosophila melanogaster
Sequence 2:	NP_505094.1	Gene:	myo-5 / 179190	WormBaseID:	WBGene00019064	Length:	1974	Species:	Caenorhabditis elegans

Alignment Length:	728	Identity:	146/728 - (20%)
Similarity:	270/728 - (37%)	Gaps:	175/728 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 RRIQNYGLLAYKMLIILSEDVYSFQQSELCTFLRLSFAGIEDCLKHWN--VAQL-RHIVDFL--- 298
            |:::....:|.:::..|:.  :..:|.::.....:..:.|:..|:...  ||:| |.|.:.|
Worm  1063 RKVEGELKIAQELIEELNR--HKHEQEQVIKKKDIELSSIQSRLEDEQSLVAKLQRQIKELLARI 1125

  Fly   299 ------LDSQSHPGLHRAMLSHGHFCEDFEKLLDQIDTSNGMDVSQEETSKHQQISLGLVFRLVS 357
                  ||::.: ...:|..:......:.|:|.|::|.:.|...:|.|.:|.::..|       :
Worm  1126 QELEEELDAERN-SRSKAEKARNEMQMELEELGDRLDEAGGATQAQIELNKKREAEL-------A 1182

  Fly   358 YILQMSEEA--NSCISLDAITPRLYEMVSDWMSSDQCGAAAIELICTLLRLGKRAAVAEMIANDP 420
            .:.|..|:|  ||..|:.|:..:..:.|::  .|||           |..:.|.....|...||.
Worm  1183 KLRQDLEDAAINSETSMAALRKKHNDAVAE--LSDQ-----------LDTIQKMRGKLEREKNDK 1234

  Fly   421 S-HVAKLVASAERPDTDAGQVLATLRLLIALLQETKTNKVVLSKISESYFDKILAAPLALVPQFL 484
            . .|.:|..||   |.:|.|.....|:...|  |.:...:.|....::...:.|......|..
Worm  1235 QREVDELQQSA---DVEAKQRQNCERMAKQL--EAQLTDMTLKSDEQARLIQELTMGKNKVHN-- 1292

  Fly   485 STQSL-AQCEVEKACFCLLLLVNVAGIAKKAYLDKCCTLLEQPQLQYCLARGMVSKNEALVAAVL 548
            ..|.| .|.|..:|..|.|   |.....:.:.|::....|:|...:.......||..:      |
Worm  1293 ENQDLNRQLEDAEAQLCAL---NRIKQQQHSQLEELKRTLDQETRERQSLHSQVSNYQ------L 1348

  Fly   549 QIAQF------EHFPKASVAKHVSAITSSPGGMMTKASAVGSDQVEQLRNLSSIFKANRIFTDKD 607
            :..||      |...|..|.:.:|...|.......|....|..:.|:|.      :..|..|.|
Worm  1349 ECEQFRESLEEEQDAKTDVQRQLSKANSEIQQWRAKFEGEGVSRAEELE------ETRRKLTHK- 1406

  Fly   608 MVQRVNALLDNIGGIVSRNELASAPTSQVIELYNHRIESLNGTVASLQQRLEQAGEQLTIGTQQA 672
             ||.:...|:|.                     |.:|    ||:...:|||....|...:...:|
Worm  1407 -VQEMQEQLENA---------------------NQKI----GTLEKNKQRLAHDLEDAQVDADRA 1445

  Fly   673 HVQSAELERFQSSNFQLLISQERLQTRCK----DLKQQKVELKSNMT---ILLKQLSENSVQLQA 730
            :..::.||:.| ..|..::.:.|  .:|:    :::|.:.|.::..|   .|..||.|:..|.:|
Worm  1446 NSIASSLEKKQ-KGFDKVLDEWR--RKCEALVAEVEQSQRETRAAATETFRLRNQLEESGEQTEA 1507

  Fly   731 NERRLTVKKSEIADLQ----------KDCENLRSKLSAKSEEL---------------------- 763
            .:|.......|:.|:.          .|.:.:|.:|..:.|||
Worm  1508 VKRENKALAQELKDIADQLGEGGKSVHDLQKMRRRLEIEKEELQQALDEAECALEAEEAKVMRAQ 1572

  Fly   764 -------TKLEAHNKENISRIDKLKKSMAAYEQDMTEKLRTIGERDRELAKTQKALE-------- 813
                   :::|...:|.....:..:|:.:...:.|...|.|......||.||:|.||
Worm  1573 IEVSQIRSEIEKRLQEKEEEFENTRKNHSRTIESMQVSLETESRGRAELLKTKKKLEGDVNELEI 1637

  Fly   814 ----------EQREACKKSEDLISVLETQLQERKAQIES-----------LEMEQKETEDLRKTI 857
                      :.:::.||.:|.|..|:.|::|.:..:..           .::.|:|.|||   .
Worm  1638 ALDHSNKLNVDGQKSMKKLQDTIRELQYQVEEEQRSLSESRDHANLAERRSQVLQQEKEDL---A 1699

  Fly   858 MSLMESKKPKRKA 870
            :...:|::.:|:|
Worm  1700 IIYEQSERTRRQA 1712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12702	NP_001259735.1	SHE3	633..827	CDD:293683	49/257 (19%)
		TMF_DNA_bd	738..793	CDD:289127	12/93 (13%)
		PRKG1_interact	787..>855	CDD:292521	22/96 (23%)
		DUF4078	<834..870	CDD:290039	8/46 (17%)
myo-5	NP_505094.1	Myosin_N	31..68	CDD:280832
		Myosin_head	83..776	CDD:278492
		MYSc_class_II	95..776	CDD:276951
		Myosin_tail_1	853..1933	CDD:279860	146/728 (20%)
		DUF4795	954..1129	CDD:292662	12/67 (18%)
		Prefoldin	1111..1243	CDD:298833	36/152 (24%)
		Tmemb_cc2	<1212..1322	CDD:287269	29/132 (22%)
		DUF881	1746..>1838	CDD:303034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000