DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and PXA1

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_015178.1	Gene:	PXA1 / 855956	SGDID:	S000006068	Length:	870	Species:	Saccharomyces cerevisiae

Alignment Length:	709	Identity:	211/709 - (29%)
Similarity:	349/709 - (49%)	Gaps:	107/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KKRK---------PGYE-DKIQYTIAEKKDKKAGKAHVNSVFFKQLRQLLPILIP-----GFWSV 85
            ||||         ..|| ||..:...|.:..|..:... |.|..|:..|..||||     .|..:
Yeast   147 KKRKRIFIPPKDNDVYEHDKFLFKNVELERAKNSQLFY-SKFLNQMNVLSKILIPTVFDKNFLLL 210

  Fly    86 ETGLLFLVAAALIGRSVSDIWMIQNATVVESTIIHMNRTKFKTALLKYLTALPAISVVTNVLKWS 150
            ...:.|||....:...|:.:    :..:|::.|....|:........:|.|:|| |...:.:|..
Yeast   211 TAQIFFLVMRTWLSLFVAKL----DGQIVKNIIAGRGRSFLWDLGCWFLIAVPA-SYTNSAIKLL 270

  Fly   151 LGELKLRFRTNLTHHLYSQYLN-GYTYYKM------SNLDNRIANADQLLTTDIDKFCESATDLY 208
            ..:|.|.||.|||.:::..||: ..|:||:      ||  :.|.|.|..:|.|:.|||::...::
Yeast   271 QRKLSLNFRVNLTRYIHDMYLDKRLTFYKLIFDAKASN--SVIKNIDNSITNDVAKFCDATCSVF 333

  Fly   209 SNISKPVLDIFIYVYRLTVNLGGKTPSILMLYLLFAGVFLTRLRRPTGRLTVEEQKLEGEFRYVN 273
            :||:|||:|:..:...|..|||....:.:.:.....|..|.:...|.|:|..|....:|::...:
Yeast   334 ANIAKPVIDLIFFSVYLRDNLGTVGVAGIFVNYFITGFILRKYTPPLGKLAGERSASDGDYYNYH 398

  Fly   274 SRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGIIDNIIGKYFASIVGFYAVS 338
            ..:|.||||:|||||...|:..:...|..|...:....:.:....::::.:.||..|.:|:...|
Yeast   399 LNMINNSEEIAFYQGTAVERTKVKELYDVLMEKMLLVDKVKFGYNMLEDYVLKYTWSGLGYVFAS 463

  Fly   339 IPFFSENHPLLSGENSGQR-LQAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTELIKVL 402
            ||.....  |.:|.||.:: ::.:....|:::.||:|..||:.:.:::|:|.|:|.|:..|:.||
Yeast   464 IPIVMST--LATGINSEEKNMKEFIVNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVL 526

  Fly   403 S-----DLNKGTY--------ERTMVNGNNL-----AQNAV-GSASSNFGPNKGIMCFEDNIIRF 448
            .     :.|.|..        |....|.|.|     :|:|: |:...||           |.||.
Yeast   527 HRVHSLNFNYGAVPSILSIRTEDASRNSNLLPTTDNSQDAIRGTIQRNF-----------NGIRL 580

  Fly   449 EKVPLVTPN-----GDVLLQELSFEVK-----------------------------SGTNVLVCG 479
            |.:.::.|:     |..|:.:|:|::.                             ||:::|:.|
Yeast   581 ENIDVIIPSVRASEGIKLINKLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQGSGSSLLILG 645

  Fly   480 PNGCGKSSLFRILGELWPTW--GGKVTKPSRGKLFYVPQRPYMTL-GTLRDQIIYPHTRDDMRRL 541
            ||||||||:.||:.|:||.:  .|.::.||...:|::||:||.:. ||||||||||.:.|:....
Yeast   646 PNGCGKSSIQRIIAEIWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDR 710

  Fly   542 GHSDEDLMHYLDIVQLTYLEQRENG---LDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDEC 603
            |..|::|:..|..|:|.||.:|..|   ||:|.||.|:||||||||:..||:.:|||.:.:|||.
Yeast   711 GFRDKELVQILVEVKLDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEA 775

  Fly   604 TSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQF----DGRGSYEFATIDQ 658
            |:|:|||:|..:::..:.......::|.|.:|..:|:..|:.    ||:...:....|:
Yeast   776 TNAISVDMEDYLFNLLKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	210/702 (30%)
		ABC_membrane_2	63..342	CDD:284003	81/290 (28%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	89/248 (36%)
PXA1	NP_015178.1	3a01203	113..827	CDD:273360	210/700 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345866
Domainoid	1	1.000	138	1.000	Domainoid score	I1045
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I444
Isobase	1	0.950	-	0	Normalized mean entropy	S1054
OMA	1	1.010	-	-		QHG53776
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		otm46586
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
TreeFam	0	0.000	Not matched by this tool.
	12	11.680