DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and PXA2

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_012733.1	Gene:	PXA2 / 853647	SGDID:	S000001671	Length:	853	Species:	Saccharomyces cerevisiae

Alignment Length:	711	Identity:	218/711 - (30%)
Similarity:	346/711 - (48%)	Gaps:	123/711 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 MSNKKRKPGYE----------DKIQYTIAEKK-----------DKKAGKAHVN-------SVFFK 69
            :.|||.:.|.|          .|.:.||..|.           ||::...|..       ...||
Yeast    51 LENKKIEEGKETAVDREEDESSKEELTIVSKHSTDSEDGAIIIDKESKTNHKGGERKGKVDFLFK 115

  Fly    70 QLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATV---VESTIIHMNRTKFKTALL 131
            .|......||          ||:..|.|:  ::..:..::.||:   :.||::......|...||
Yeast   116 LLLHDKKCLI----------LFITQAILL--NIRTLLSLRVATLDGQLVSTLVRAQYANFTKILL 168

  Fly   132 -KY-LTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYL-NGYTYYKMSNLDNRIANADQLL 193
             |: :..:|| |.:.:::.::.....:.....::..|.|:|| |.:|:|.:::.:: ::.....|
Yeast   169 GKWMILGIPA-SFINSLISYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAES-VSEIQDNL 231

  Fly   194 TTDIDKFCESATDLYSNISKPVLDIFIYVYR-LTVNLGGKTPSILMLYLL-FAGVFLTRLRRPT- 255
            |.||..|..:::.|.:.:.||:||:.:..:: ||.|........|.|.|: :|...|.:|.:|.
Yeast   232 TKDIYTFSMNSSLLLNQLLKPMLDLILCSFKLLTSNTSVMGEGTLALGLIVYASNSLLKLIQPNF 296

  Fly   256 GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGII 320
            .|||:....||..||.::|.|.:::||:|..:|..||...:..|:.:|...|.:.::.|....:.
Yeast   297 TRLTMASASLESWFRSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDVA 361

  Fly   321 DNIIGKYFASIVGFYAVSIPFFSENHP---LLSGENSGQRLQA-YYTYGRMLVKLAEAIGRLVLA 381
            ...:.||.....|....|||.|.:|.|   .|..:..|..:.| :.|..|:||..:.:|||.|..
Yeast   362 TAFVIKYTWGAAGLVLCSIPIFFKNKPSEDTLQLKEPGNDMTADFITNRRLLVTASSSIGRFVEL 426

  Fly   382 GREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQNAVGSASSNFGPNKGIMCFEDNII 446
            .|.:.:|.|...|:.:...:| |.|||..|:...:                  .:.|:.::|:.|
Yeast   427 KRNIQQLRGIRLRLNKFNDLL-DANKGDDEKEPRD------------------ERCIVEYDDSRI 472

  Fly   447 RFEKVPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSLFRILGELWP-------TWGGKVT 504
            :||.:||:||...||:.||||::|.|.::|:.|||||||||||||||.|||       ....|:.
Yeast   473 KFENIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLI 537

  Fly   505 KPSRG-----KLFYVPQRPYM-TLGTLRDQIIYPHTRDDMRRLGHSDEDL--------MHYLDIV 555
            .|.|.     .:||:|||||| ...|.|:|||||.:.:..:...|:|.||        :..||:.
Yeast   538 MPRRTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLDLE 602

  Fly   556 QLT------YLEQRENGLDS----------------------IEDWIDVLSGGEKQRIAMARLFY 592
            .|.      .|.||.:..||                      :.:|.:.|:.|.:||:||||::|
Yeast   603 DLVTENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYY 667

  Fly   593 HKPQFAILDECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEF 653
            |||:||:||||||||:.::|.:||...:..||:|.:|.||.|||..|:|.|:|||:|.|:|
Yeast   668 HKPKFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQF 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	217/709 (31%)
		ABC_membrane_2	63..342	CDD:284003	72/294 (24%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	106/253 (42%)
PXA2	NP_012733.1	3a01203	24..728	CDD:273360	217/709 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I3241
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1054
OMA	1	1.010	-	-		QHG53776
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.700