DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and abcd1

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_005166771.1	Gene:	abcd1 / 566367	ZFINID:	ZDB-GENE-050517-27	Length:	766	Species:	Danio rerio

Alignment Length:	689	Identity:	257/689 - (37%)
Similarity:	381/689 - (55%)	Gaps:	73/689 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LWIIAYGKMSNKKRKPGYEDKIQ-----------------YTIAEKKDKKAGKAHVNSVFFKQLR 72
            |.|..||.   ||..|.:..|::                 ..:.|...|:.....||..||.:|.
Zfish    22 LLIALYGV---KKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFFDRLI 83

  Fly    73 QLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVESTIIHMNRTKFKTALLKY-LTA 136
            :||.||.|..:..|.|||...:.|||.|:...|::......:..||:..:...|...|.|: |.|
Zfish    84 RLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIA 148

  Fly   137 LPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIANADQLLTTDIDKFC 201
            :|| :.|.:.:::..|:|.|.|||.|..|.|..|.:..|||::||:|.|:||.||.||.|:..|.
Zfish   149 IPA-TFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFA 212

  Fly   202 ESATDLYSNISKPVLDIFIYVYRL---TVNLGGKT--PSILMLYLLFAGVFLTRLRRPT-GRLTV 260
            .|...||||::||:||:.:..|.|   ..:.|..|  ||::...::.....:.|...|. |:|..
Zfish   213 ASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVA 277

  Fly   261 EEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGIIDNIIG 325
            ||.:.:|:.||::||:|.||||:|||.|:..|.|.|..||:.|...:...|..|:...:::..:.
Zfish   278 EEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLM 342

  Fly   326 KYFASIVGFYAVSIPFFS-------------------ENHPLLSGENSGQRLQAYYTYGRMLVKL 371
            ||..|..|...|::|..:                   :...|:|     :|.||:.|...:|...
Zfish   343 KYLWSASGLVMVAVPIITATGYSKYDSEDVKQAALDMKEEDLVS-----ERTQAFTTARSLLNAA 402

  Fly   372 AEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQNAVGSASSNF---G 433
            |:|:.|::::.:|::.|||:|||:.|:.:|..|:..|.|.|:..........|..:.:...   |
Zfish   403 ADAVERIMVSYKEVTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEG 467

  Fly   434 P----------NKGIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSL 488
            |          .:||.|        |.:|::||.|||::..|:.:|..|.::|:.||||||||||
Zfish   468 PLQIRGQVIDVEQGIKC--------ENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSL 524

  Fly   489 FRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLD 553
            ||||..|||.:.|.:.|||...:||:||||||::||||||:||||:..:|:..|.:|..|...|.
Zfish   525 FRILSGLWPVYSGVLYKPSPDHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQ 589

  Fly   554 IVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSY 618
            .|.|.|:.:||.|.|::.||.||||||||||:.|||:||||||:|:|||||||||:|||||::..
Zfish   590 TVSLRYILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEA 654

  Fly   619 CREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            .::.||:|.:::||.|||.:|.:.|||||.|.:.|..:|
Zfish   655 AKDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	255/683 (37%)
		ABC_membrane_2	63..342	CDD:284003	103/285 (36%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	113/204 (55%)
abcd1	XP_005166771.1	SunT	1..689	CDD:331423	255/683 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760