Protein Alignment Abcd3 and Abcd1

DIOPT Version :10

• Sequence 1: NP_608354.1
• Gene: Abcd3 / 32992
• FlyBaseID: FBgn0031069
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001102291.1
• Gene: Abcd1 / 363516
• RGDID: 1562128
• Length: 737
• Species: Rattus norvegicus
• Alignment Length: 705
• Identity: 259/705 - (36%)
• Similarity: 395/705 - (56%)
• Gaps: 70/705 - (9%)

  Fly     3 PALSKLANNQSAIVGVAGMTAALWIIAYG---------KMSNKKRKPGYEDKIQYTIAEKKDKKA 58
            |.|| ..:..|.:..:......|.:.|||         :.....|.|      |....|...:.:
  Rat     2 PVLS-TPSRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGP------QVPAGESTQEAS 59

  Fly    59 G----KAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVESTII 119
            |    ||.:|.||.::|..||.:|.||....|||||.|.:|||:.|:...:::.:....:...|:
  Rat    60 GATTAKAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIV 124

  Fly   120 HMNRTKFKTALLKY-LTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLD 183
            ..:...|...||:: |.|||| :.:.:.:::..|:|.|.||:.|..|.|..|.:..|||::||:|
  Rat   125 RKDPRAFSWQLLQWLLIALPA-TFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMD 188

  Fly   184 NRIANADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL-----TVNLGGKTPSILMLYLLF 243
            .|:.|.||.||.|:..|..|...||||::||:||:.:..|.|     :...|...||.:...::|
  Rat   189 GRLRNPDQSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVF 253

  Fly   244 AGVFLTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHL 307
            ....:.|...|. |.|..||.:.:||.||::||::.||||:|||.|:..|...|..||..|.|.:
  Rat   254 LTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQI 318

  Fly   308 RKFLEFRVSMGIIDNIIGKYFASIVGFYAVSIPF-----FSENH---------PLLSGENSGQRL 358
            ...|..|:...:::..:.||..|..|...|::|.     ::|:.         .:...|...:|.
  Rat   319 NLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERT 383

  Fly   359 QAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQN 423
            :|:.....:|...|:|..|::.:.:|::.|||:|||:.|:.:|..|:....::||    .:|.:.
  Rat   384 EAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRT----GDLEEA 444

  Fly   424 AVGSASSNF------GPNK----------GIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVKSG 472
            ..|..|...      ||.|          ||:|        |.:|::||.|:|::..|:..|:.|
  Rat   445 QAGPGSMVHSGVHIEGPLKIQGQVVDVEQGIIC--------ENIPIITPTGEVVVASLNIRVEEG 501

  Fly   473 TNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTRDD 537
            .::|:.|||||||||||||||.||||:.|.:.||...::||:||||||::|:||||:|||.:.:|
  Rat   502 MHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAED 566

  Fly   538 MRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDE 602
            |||.|.|::.|...|.||.|.::.|||.|.:::.||.|||||||||||.|||:|||:|::|:|||
  Rat   567 MRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDE 631

  Fly   603 CTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            ||||||:|||||::...::.||:|.:::||.|||.:|.:.|||||.|.::|..:|
  Rat   632 CTSAVSIDVEGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKFEKLD 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abcd3	NP_608354.1	3a01203	3..653	CDD:273360	257/699 (37%)
Abcd1	NP_001102291.1	3a01203	1..682	CDD:273360	257/699 (37%)
		Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P33897	68..187		41/119 (34%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250|UniProtKB:P33897	68..85		7/16 (44%)
		Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P33897	659..737		14/28 (50%)