DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pmp70 and Abcd2

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_036124.2	Gene:	Abcd2 / 26874	MGIID:	1349467	Length:	741	Species:	Mus musculus

Alignment Length:	689	Identity:	266/689 - (38%)
Similarity:	394/689 - (57%)	Gaps:	64/689 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GVAGMTAALWIIAYGK------MSNKKRKPGY-EDKIQ-YTIAEKKD---------KKAGKAHVN 64
            |.|...|.|...||..      :..:.::||: :.|.: |:.||.::         ||.... :|
Mouse    18 GAAKRAACLVAAAYALKTLYPIIGKRLKQPGHRKAKAEAYSPAENREILHCTEIICKKPAPG-LN 81

  Fly    65 SVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMI-QNATVVESTIIHMNRTKFKT 128
            :.|||||.:|..||.|...:.|||.|.|.:.|||.|:...|::. .:..:|:|.:....|| |..
Mouse    82 AAFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRT-FII 145

  Fly   129 ALLKYL-TALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIANADQL 192
            .|:|:| .|:|| :.|.:.:::...:|.|.|||.|..|.|..|....||||:.|:|.|:||.||.
Mouse   146 KLIKWLMIAIPA-TFVNSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQS 209

  Fly   193 LTTDIDKFCESATDLYSNISKPVLDIFIYVYRL--TVNLGGKT---PSILMLYLLFAGVFLTRLR 252
            ||.||..|.:|...||||::||:||:.:..|.|  |....|.:   |::|...:::|...:.:..
Mouse   210 LTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKAC 274

  Fly   253 RPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVS 316
            .|. |.|..||...:|..|||:||:|.|.||:|||:|:..|...|...|..|...:...|..|:.
Mouse   275 SPKFGSLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLILSKRLW 339

  Fly   317 MGIIDNIIGKYFASIVGFYAVSIPFFS---------ENHP---LLSGENSGQRLQAYYTYGRMLV 369
            ..:|:..:.||..|..|...|:||..:         |:.|   ::|     .|.:|:.|...:|.
Mouse   340 YIMIEQFLMKYVWSSCGLIMVAIPIITATGFADGDLEDGPKQAMVS-----DRTEAFTTARNLLA 399

  Fly   370 KLAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMV--------NGNNL---AQN 423
            ..|:||.|::.:.:|::.|||:|||:..:..|..::.:|.|:||:.        .|.||   ..:
Mouse   400 SGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPENHSKRGGNLELPLSD 464

  Fly   424 AVGSASSNFGPNKGIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSL 488
            .:....:....:.||:|        |.||::||.|:|:...|:|:|:.|.::|:.||||||||||
Mouse   465 TLAIKGTVIDVDHGIIC--------ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSL 521

  Fly   489 FRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLD 553
            ||||..|||.:.|.:.||....:||:||||||:||:||||:|||.:.||||..|::|:||...|.
Mouse   522 FRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSADDMREKGYTDQDLERILH 586

  Fly   554 IVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSY 618
            .|.|.::.|||.|.|::.||.||||||||||:.|||:|||||::|:|||||||||:|||||::..
Mouse   587 SVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQA 651

  Fly   619 CREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            ....||:|.:::||.|||.:|.:.|||||.|.:.|..:|
Mouse   652 AIGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLD 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	264/683 (39%)
		ABC_membrane_2	63..342	CDD:284003	106/286 (37%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	115/204 (56%)
Abcd2	NP_036124.2	Interaction with PEX19. /evidence=ECO:0000250	1..218		70/202 (35%)
		3a01203	74..686	CDD:273360	252/627 (40%)
		ABC_membrane_2	80..365	CDD:284003	106/286 (37%)
		ABCD_peroxisomal_ALDP	479..684	CDD:213190	117/212 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760