DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and Abcd3

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_036936.1	Gene:	Abcd3 / 25270	RGDID:	2007	Length:	659	Species:	Rattus norvegicus

Alignment Length:	670	Identity:	384/670 - (57%)
Similarity:	487/670 - (72%)	Gaps:	21/670 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALSK--LANNQSAIVGVAGMTAALWII------AYGKMSNKKRKPGYEDKIQYTIAEKKDKKAGK 60
            |.||  .|.|.|    :||....|:.:      |.|....|..||..::.      ||:.||. :
  Rat     3 AFSKYLTARNSS----LAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNN------EKEGKKE-R 56

  Fly    61 AHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVESTIIHMNRTK 125
            |.|:.||..:|.|:|.|::|..:..|||.|.|:|..|:.|:..|:|||||.|::||.||..:...
  Rat    57 AVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKD 121

  Fly   126 FKTALLKYLTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIANAD 190
            ||..|..::.|:|.||:|.|.||:.|.||||.||..||.:||.:||..:|||||.||||||||.|
  Rat   122 FKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPD 186

  Fly   191 QLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRLTVNLGGKTPSILMLYLLFAGVFLTRLRRPT 255
            ||||.|::|||.|..|||||:|||.|||.:|:::||..:|.:.|:.:|.|||.:|:||||||||.
  Rat   187 QLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPI 251

  Fly   256 GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGII 320
            |::|:.|||.|||:|:|||||||||||:|||.||.|||.|:.:.:.||..||..|:.||.|||.|
  Rat   252 GKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFI 316

  Fly   321 DNIIGKYFASIVGFYAVSIPFFSENHPLLSGENSGQRLQAYYTYGRMLVKLAEAIGRLVLAGREM 385
            |:||.||.|::||:..||.||....||........:.|:.||..||||:::::|:||:|||||||
  Rat   317 DSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREM 381

  Fly   386 SRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQNAVGSASSNFGPNKGIMCFEDNIIRFEK 450
            :||||||||:|||::||.|||.|.||||||:..:  :...|:.:|...|..|.:...||||:|:.
  Rat   382 TRLAGFTARITELMQVLKDLNHGKYERTMVSQQD--KGIEGAQASPLIPGAGEIINADNIIKFDH 444

  Fly   451 VPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVP 515
            |||.|||||:|:|:|||||:||.|||:|||||||||||||:||||||.:||.:|||.||||||||
  Rat   445 VPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVP 509

  Fly   516 QRPYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGG 580
            |||||||||||||:|||..::|.::.|.||:.|..|||.|||.::.:||.|.||::||:||||||
  Rat   510 QRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGG 574

  Fly   581 EKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQF 645
            ||||:|||||||||||||||||||||||||||..:||:||:|||||||||||||||.||:|||..
  Rat   575 EKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHM 639

  Fly   646 DGRGSYEFATIDQDKDHFGS 665
            ||||:|||..|.:|...|||
  Rat   640 DGRGNYEFKKITEDTVEFGS 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	377/656 (57%)
		ABC_membrane_2	63..342	CDD:284003	154/278 (55%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	153/204 (75%)
Abcd3	NP_036936.1	3a01203	1..647	CDD:273360	377/656 (57%)
		Interaction with PEX19. /evidence=ECO:0000250	2..199		92/206 (45%)
		Targeting to peroxisomes. /evidence=ECO:0000250	2..124		47/131 (36%)
		ABC_membrane_2	59..338	CDD:284003	154/278 (55%)
		ABCD_peroxisomal_ALDP	440..645	CDD:213190	153/204 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352267
Domainoid	1	1.000	313	1.000	Domainoid score	I1260
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2140
Inparanoid	1	1.050	757	1.000	Inparanoid score	I528
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		oto95951
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770