DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pmp70 and ABCD2

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_005155.1	Gene:	ABCD2 / 225	HGNCID:	66	Length:	740	Species:	Homo sapiens

Alignment Length:	689	Identity:	266/689 - (38%)
Similarity:	391/689 - (56%)	Gaps:	53/689 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKLANNQSAIVGVAGMTAALWIIAYGKMS----NKKRKPGY----EDKIQY---TIAEKKDKKAG 59
            |..|...:.:|..|.....|:.|...::.    .||:...|    ..:|.:   ||.||.
Human    17 SSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICEKP----- 76

  Fly    60 KAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMI-QNATVVESTIIHMNR 123
            ...||:.|||||.:|..||.|...:.|||.|.|.:.|||.|:...|::. .:..:|:|.:....|
Human    77 SPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPR 141

  Fly   124 TKFKTALLKYL-TALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIA 187
            | |...|:|:| .|:|| :.|.:.:::...:|.|.|||.|..|.|..|....||||:.|:|.|:|
Human   142 T-FIIKLIKWLMIAIPA-TFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLA 204

  Fly   188 NADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL--TVNLGGKT---PSILMLYLLFAGVF 247
            |.||.||.||..|.:|...||||::||:||:.:..|.|  |....|.:   |::|...:::|...
Human   205 NPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAK 269

  Fly   248 LTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFL 311
            :.:...|. |:|..||...:|..|||:||:|.|.||:|||:|:..|...|..||..|...:...|
Human   270 VLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLIL 334

  Fly   312 EFRVSMGIIDNIIGKYFASIVGFYAVSIPFFSENHPLLSGENS------GQRLQAYYTYGRMLVK 370
            ..|:...:|:..:.||..|..|...|:||..:.. ....||:.      .:|.:|:.|...:|..
Human   335 SKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITAT-GFADGEDGQKQVMVSERTEAFTTARNLLAS 398

  Fly   371 LAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMV---------NGNNL---AQN 423
            .|:||.|::.:.:|::.|||:|||:..:..|..::.:|.|:||.|         ||..:   ..:
Human   399 GADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSD 463

  Fly   424 AVGSASSNFGPNKGIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSL 488
            .:.........:.||:|        |.||::||.|:|:...|:|:|:.|.::|:.||||||||||
Human   464 TLAIKGKVIDVDHGIIC--------ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSL 520

  Fly   489 FRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLD 553
            ||||..|||.:.|.:.||....:||:||||||:||:||||:|||.:.|||...|::|:||...|.
Human   521 FRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH 585

  Fly   554 IVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSY 618
            .|.|.::.|||.|.|::.||.||||||||||:.|||:|||||::|:|||||||||:|||||::..
Human   586 NVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQA 650

  Fly   619 CREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            .:..||:|.:::||.|||.:|.:.|||||.|.:.|..:|
Human   651 AKGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLD 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	264/683 (39%)
		ABC_membrane_2	63..342	CDD:284003	108/286 (38%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	114/204 (56%)
ABCD2	NP_005155.1	Interaction with PEX19	1..218		71/207 (34%)
		3a01203	74..685	CDD:273360	252/626 (40%)
		ABC_membrane_2	80..365	CDD:284003	108/286 (38%)
		ABCD_peroxisomal_ALDP	478..683	CDD:213190	116/212 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760