DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and ABCD1

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_000024.2	Gene:	ABCD1 / 215	HGNCID:	61	Length:	745	Species:	Homo sapiens

Alignment Length:	642	Identity:	251/642 - (39%)
Similarity:	380/642 - (59%)	Gaps:	60/642 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AGKAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVESTIIHMN 122
            |.||.:|.||.::|..||.:|.|.....|||||.|.:|||:.|:...:::.:....:...|:..:
Human    62 AAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKD 126

  Fly   123 RTKFKTALLKY-LTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRI 186
            ...|...||:: |.|||| :.|.:.:::..|:|.|.||:.|..|.|..|.:..|||::||:|.|:
Human   127 PRAFGWQLLQWLLIALPA-TFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRL 190

  Fly   187 ANADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL-----TVNLGGKTPSILMLYLLFAGV 246
            .|.||.||.|:..|..|...||||::||:||:.:..|.|     :...|...||.:...::|...
Human   191 RNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTA 255

  Fly   247 FLTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKF 310
            .:.|...|. |.|..||.:.:||.||::||::.||||:|||.|:..|...|..||..|.|.:...
Human   256 NVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLI 320

  Fly   311 LEFRVSMGIIDNIIGKYFASIVGFYAVSIPF-----FSEN--------------HPLLSGENSGQ 356
            |..|:...:::..:.||..|..|...|::|.     :||:              ..|:|     :
Human   321 LLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVS-----E 380

  Fly   357 RLQAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNLA 421
            |.:|:.....:|...|:||.|::.:.:|::.|||:|||:.|:.:|..|:.:..::|.    ..|.
Human   381 RTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRP----RELE 441

  Fly   422 QNAVGSASSN------FGPNK----------GIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVK 470
            ....||.:..      .||.|          ||:|        |.:|:|||:|:|::..|:..|:
Human   442 DAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIIC--------ENIPIVTPSGEVVVASLNIRVE 498

  Fly   471 SGTNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTR 535
            .|.::|:.|||||||||||||||.||||:||.:.||...::||:||||||::|:||||:|||.:.
Human   499 EGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSV 563

  Fly   536 DDMRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAIL 600
            :||:|.|:|::||...||:|.|.::.|||.|.:::.||.|||||||||||.|||:|||:|::|:|
Human   564 EDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALL 628

  Fly   601 DECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            ||||||||:|||||::...::.||.|.:::||.|||.:|.:.|||||.|.::|..:|
Human   629 DECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLD 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	249/636 (39%)
		ABC_membrane_2	63..342	CDD:284003	100/290 (34%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	115/204 (56%)
ABCD1	NP_000024.2	3a01203	1..681	CDD:273360	249/636 (39%)
		Interaction with PEX19. /evidence=ECO:0000269\|PubMed:10777694	67..186		41/119 (34%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269\|PubMed:15781447	67..84		7/16 (44%)
		ABC_membrane_2	83..352	CDD:284003	93/269 (35%)
		ABCD_peroxisomal_ALDP	474..679	CDD:213190	117/212 (55%)
		Required for homodimerization. /evidence=ECO:0000269\|PubMed:17609205	658..745		14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760