DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmp70 and pmp-3

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001256607.1	Gene:	pmp-3 / 179968	WormBaseID:	WBGene00004060	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	187/696 - (26%)
Similarity:	301/696 - (43%)	Gaps:	150/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 KAGKAHVNSVFFKQLRQLLPILIP-----------GFWSVETGL-------------LFLVAAAL 97
            |..:..::.:||::..:||.||.|           |...:.|.|             ||.||
Worm    28 KMARLALDFLFFRRFWRLLKILFPCHRRSITAWLAGALLIATALDQVMTYLVGIQPSLFYVA--- 89

  Fly    98 IGRSVSDIWMI---QNATVVESTIIHMNRTKFKTALLKYLTALPAISVVTNVLKWSLGELKLRFR 159
            :|...:|.:.|   :.|.::..       ..|..|:.||||.:.||              |.|..
Worm    90 LGNKDADTFKILCARGAAIILG-------KAFTLAVFKYLTNMLAI--------------KSRQV 133

  Fly   160 TNLTHHLYSQYLNGYTYYKMSNLDNRIANADQLLTTDIDKFCESATDLYSN-----ISKPVLDIF 219
            .|||.|  ..|.....::|:|:..:.:.|.||.||.||:|    ||.:.||     |:.....|.
Worm   134 CNLTMH--RLYFKRQAFFKLSSSGDMLDNPDQRLTQDIEK----ATRILSNDLLAPIATAPFIIG 192

  Fly   220 IYVYRLTVNLGGKTPSILMLYLLFAGVFLTRLRRPTGRLTVEEQKLEGEFRYVNSRLITNSEEVA 284
            .|.:....:.|...|:.:..|.....:....:..|..:...|::|:||:||..:..:.:|.|.:|
Worm   193 YYTWLTYESSGWIGPAAIYTYFCIQTIINKMILSPIVQKVSEQEKMEGDFRQRHMEVRSNVEAIA 257

  Fly   285 FYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGIIDNIIGKYFASIVGFYAVSIPFF------- 342
            ||:..|.|.:........|....:...|:|:.:..|.|:. .||..|:.:..:.:|.|
Worm   258 FYRAGVLENIMTNQKLKNLIETQKSLTEWRMVLNSITNVF-DYFGGILSYLIIGVPVFITHLYDD 321

  Fly   343 ---SENHPLLSGENSGQRLQAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTEL------ 398
               :|.:.::| .|:...|...|::..:| ||....|          .|||.|.|:.||
Worm   322 VSPAELNGIVS-RNAFFYLYLIYSFSTVL-KLTGDFG----------ELAGVTHRVMELHEELNR 374

  Fly   399 -------------------IKVLSDLNKGTYERTM--VNGNNL-----------AQNAVG--SAS 429
                               :.:.||.:..:..|.|  ::|..:           ||..:|  :..
Worm   375 LHSDCLETDRPPSTVPSSVVVIASDEDDKSASRHMQEIHGKQMSLERDEQEEEEAQYLLGGKTGQ 439

  Fly   430 SNFGPNKGIMCFEDNIIRFEKVPLVTPN--GDVLLQELSFEVKSGTNVLVCGPNGCGKSSLFRIL 492
            .:..|:.|:      .|..:...|..||  ..:::|.||.::..|..:|:.|.:|||||||.|:.
Worm   440 EDDWPDDGV------AITVDSATLSPPNDHSHLIVQLLSLQIIQGQTLLITGDSGCGKSSLLRMF 498

  Fly   493 GELWPTWGGKVT---KPSRGKLFYVPQRPYMTLG--TLRDQIIYPHTRDDMRRLGHSDED---LM 549
            ..||....||:.   :.....||::.|:||...|  |||.||:||     ::.| ..|:|   :.
Worm   499 AGLWHCSSGKMDCHWRRLTSNLFFLAQKPYFPSGNTTLRQQIVYP-----VKAL-QVDKDVARIT 557

  Fly   550 HYLDIVQLTYLEQRENGLDS-IE-DWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVE 612
            ..|:.|::.:|.:|..|||: :| ||:..||.||.||:::||:||.||:...|||.|||:..::|
Worm   558 QILEWVKMEHLVERCGGLDTPVEWDWMKTLSPGELQRLSLARVFYTKPRIVFLDESTSAIGFELE 622

  Fly   613 GKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGR-GSYEFATID 657
            ..:|...:|..||..::.||.||...||..|:..|| |.:....||
Worm   623 MAIYRKLQEEKITFVSIGHRYSLKQFHDMELRVKGRSGEWSLHDID 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	185/690 (27%)
		ABC_membrane_2	63..342	CDD:284003	76/310 (25%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	81/217 (37%)
pmp-3	NP_001256607.1	ABC_membrane_2	34..314	CDD:284003	76/310 (25%)
		YddA	37..655	CDD:226646	181/672 (27%)
		ABCD_peroxisomal_ALDP	450..662	CDD:213190	81/217 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820