DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and SPTBN4

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_066022.2	Gene:	SPTBN4 / 57731	HGNCID:	14896	Length:	2564	Species:	Homo sapiens

Alignment Length:	151	Identity:	40/151 - (26%)
Similarity:	66/151 - (43%)	Gaps:	29/151 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 EYDDLGMRCEKDAFDT----LIDC------APDKLAVVKKSLITFVNKHLAKLNFEISDLNTDFR 286
            |..|.|...|:.|..|    |.:|      |.::.||.||:...:||.|||::...|.||..|.|
Human    26 ESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLR 90

  Fly   287 DGVYLCLLMGLLGGFFVP--------LHEFHLTPQDVDQMVSNVAFAFDLMQDVGLPKPKARPED 343
            ||..|..|:.:|.|..:|        :|.           :.||..|...:::..:........|
Human    91 DGFVLTRLLEVLSGEQLPRPTRGRMRIHS-----------LENVDKALQFLKEQRVHLENVGSHD 144

  Fly   344 IVNMDLKSTLRVLYSLFTMFR 364
            ||:.:.:.||.:::::...|:
Human   145 IVDGNHRLTLGLVWTIILRFQ 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723
parvin	NP_001285464.1	CH	258..359	CDD:278723	29/108 (27%)
SPTBN4	NP_066022.2	Actin-binding	1..282		40/151 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		4/10 (40%)
		CH	62..165	CDD:237981	29/113 (26%)
		CH	181..284	CDD:237981
		SPEC	311..419	CDD:295325
		Spectrin 1. /evidence=ECO:0000255	311..418
		SPEC	430..644	CDD:238103
		Spectrin 2. /evidence=ECO:0000255	430..533
		Spectrin 3. /evidence=ECO:0000255	536..641
		Spectrin 4. /evidence=ECO:0000255	774..879
		SPEC	775..987	CDD:238103
		Spectrin 5. /evidence=ECO:0000255	884..982
		Spectrin 6. /evidence=ECO:0000255	1089..1196
		SPEC	1091..1195	CDD:197544
		SPEC	1201..1409	CDD:238103
		SPEC	1306..1514	CDD:238103
		Spectrin 7. /evidence=ECO:0000255	1306..1407
		Spectrin 8. /evidence=ECO:0000255	1412..1512
		Spectrin 9. /evidence=ECO:0000255	1515..1617
		SPEC	1516..1727	CDD:238103
		SPEC	1622..1834	CDD:238103
		Spectrin 10. /evidence=ECO:0000255	1623..1725
		Spectrin 11. /evidence=ECO:0000255	1728..1830
		Spectrin	1834..1933	CDD:278843
		Spectrin 12. /evidence=ECO:0000255	1835..1935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1853..1872
		SPEC	1943..>2110	CDD:238103
		Spectrin 13. /evidence=ECO:0000255	1944..2046
		Spectrin 14. /evidence=ECO:0000255	2049..2123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2208..2439
		PH	2419..2527	CDD:278594
		PH_beta_spectrin	2421..2525	CDD:269975
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2533..2564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910