DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment parvin and Parva

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_065707.2	Gene:	Parva / 57341	RGDID:	71021	Length:	372	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	207/360 - (57%)
Similarity:	267/360 - (74%)	Gaps:	2/360 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PKSPHTPTAIKKGEKEDSFWDKF-STLGRKRGTREVKKVQEEGKYAIDSPGSPSQYDIPPEDYAL 70
            |||| ||.:....:|:|||..|. .||.|::..:||.:.||||..||:.|.||..:::.|||..|
  Rat    12 PKSP-TPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTML 75

  Fly    71 REHEQRAVIDPQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWEKLTGKK 135
            .|:|.|.::||.|.:||::.:|.::|:|||||.|..:||||:.|.||:||||||.||:|||..:|
  Rat    76 EENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEK 140

  Fly   136 LDVPEVTQSEQGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVRHFRAPV 200
            |:|.||||||..|.:||..||:.:|..|....:..||:|.|||:||:||||||||||.::||||:
  Rat   141 LNVAEVTQSEIAQKQKLQTVLEKINEALKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPI 205

  Fly   201 RLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGMRCEKDAFDTLIDCAPDKLAVVKKSLIT 265
            |||::|.:.||:.:|..|:|.:::.||:||...:.|..|.|:||||||.|.|||||.||||:|||
  Rat   206 RLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLIT 270

  Fly   266 FVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQMVSNVAFAFDLMQ 330
            ||||||.|||.|:::|.|.|.|||||.||||||.|:|||||.|.|||...:|.|.||:|||:|||
  Rat   271 FVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQ 335

  Fly   331 DVGLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRD 365
            |.||.|||.|||||||.||||||||||:|||.:|:
  Rat   336 DGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRN 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	58/99 (59%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	74/100 (74%)
Parva	NP_065707.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		14/32 (44%)
		Interaction with ARHGAP31. /evidence=ECO:0000250\|UniProtKB:Q9EPC1	21..25		0/3 (0%)
		CH	96..197	CDD:278723	58/100 (58%)
		Required for interaction with TESK1 and ILK. /evidence=ECO:0000250\|UniProtKB:Q9NVD7	223..372		99/148 (67%)
		CH	263..364	CDD:278723	74/100 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339058
Domainoid	1	1.000	158	1.000	Domainoid score	I4019
eggNOG	1	0.900	-	-		E1_KOG3631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1847
OMA	1	1.010	-	-		QHG52959
OrthoDB	1	1.010	-	-		D373611at33208
OrthoFinder	1	1.000	-	-		FOG0002943
OrthoInspector	1	1.000	-	-		otm44959
orthoMCL	1	0.900	-	-		OOG6_105758
Panther	1	1.100	-	-	O	PTHR12114
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770