DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and parvab

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001103941.1	Gene:	parvab / 567123	ZFINID:	ZDB-GENE-070424-60	Length:	367	Species:	Danio rerio

Alignment Length:	360	Identity:	206/360 - (57%)
Similarity:	269/360 - (74%)	Gaps:	4/360 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PKSPHTPTAIKKGEKEDSFWDKF-STLGRKRGTREVKKVQEEGKYAIDSPGSPSQYDIPPEDYAL 70
            |.||.:|::.|   |:|||..|. .||.|::..:||.::||||..||:.|.||:.:::.|||..|
Zfish     9 PSSPKSPSSRK---KDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPTPFELDPEDTML 70

  Fly    71 REHEQRAVIDPQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWEKLTGKK 135
            .|:|.|.::||.|.:||::.:|.::|:|||||.|..:||||:.|.||:||||||.||:|||.|:|
Zfish    71 DENEVRTMVDPHSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLEGEK 135

  Fly   136 LDVPEVTQSEQGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVRHFRAPV 200
            |:|.||||.|..|.:||..||:.:|.||....:..:|:|.|||:||||||||||||:.:|||||:
Zfish   136 LNVAEVTQCEIAQKQKLQTVLEKINDTLKVSSRNIRWNVESVHAKNIVAILHLLVAISQHFRAPI 200

  Fly   201 RLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGMRCEKDAFDTLIDCAPDKLAVVKKSLIT 265
            ||||:|.:.||:.:|..|:|.:::.||:||..::.|..|.|:||||||.|.|||||.||||:|||
Zfish   201 RLPEHVSIQVVVVQKREGILQSRQIQEEITGNFEALSGRYERDAFDTLFDHAPDKLNVVKKTLIT 265

  Fly   266 FVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQMVSNVAFAFDLMQ 330
            ||||||.|||.|:|:|.|.|.|||||.||||||.|:||||:.|.|.|:..|..|.||||:|:|||
Zfish   266 FVNKHLNKLNLEVSELETQFADGVYLVLLMGLLEGYFVPLYNFFLIPEHFDHKVHNVAFSFELMQ 330

  Fly   331 DVGLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRD 365
            |..|.|||.|||||||.||||||||||:|||.:|:
Zfish   331 DGDLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	59/99 (60%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	72/100 (72%)
parvab	NP_001103941.1	CH	91..192	CDD:278723	59/100 (59%)
parvab	NP_001103941.1	CH	258..359	CDD:278723	72/100 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578636
Domainoid	1	1.000	154	1.000	Domainoid score	I4212
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1875
OMA	1	1.010	-	-		QHG52959
OrthoDB	1	1.010	-	-		D373611at33208
OrthoFinder	1	1.000	-	-		FOG0002943
OrthoInspector	1	1.000	-	-		otm24706
orthoMCL	1	0.900	-	-		OOG6_105758
Panther	1	1.100	-	-	O	PTHR12114
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2710
SonicParanoid	1	1.000	-	-		X1944
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940