DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and actn1

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_005157053.1	Gene:	actn1 / 560400	ZFINID:	ZDB-GENE-081113-4	Length:	924	Species:	Danio rerio

Alignment Length:	320	Identity:	69/320 - (21%)
Similarity:	114/320 - (35%)	Gaps:	90/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 QYDIPPEDYALREHEQRAVIDPQSISDPQVIKLQR-ILVDWINDELAEQRIIVQHLEEDMYDGQV 123
            |||....||..:|.:.    |...:.||...|.|| ....|.|..|.:....::::|||..||..
Zfish    14 QYDGGENDYMQQEDDW----DRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLK 74

  Fly   124 LHKLWEKLTGKKLDVPEVTQSEQGQHEKLNIVLKAVNHTLGF----HQKIPKWSVASVHSKNIVA 184
            |..|.|.::|::|..||  :.:...|:..|     ||..|||    ..|:.......:...|...
Zfish    75 LMLLLEVISGERLAKPE--RGKMRVHKISN-----VNKALGFIASKGVKLVSIGAEEIVDGNAKM 132

  Fly   185 ILHLLVALVRHFRAPVRLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGMRCEKDAFDTLI 249
            .|.::..::..|.                        .|....:.||..:.|.:.|::..
Zfish   133 TLGMIWTIILRFA------------------------IQDISVEETSAKEGLLLWCQRKT----- 168

  Fly   250 DCAPDKLAVVKKSLITFVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQD 314
              ||.|                   |..|.:.:..::||:..|.|          :|...  |:.
Zfish   169 --APYK-------------------NVNIQNFHISWKDGLGFCAL----------IHRHR--PEL 200

  Fly   315 V-------DQMVSNVAFAFDLMQD-VGLPKPKARPEDIVNM---DLKSTLRVLYSLFTMF 363
            :       |..::|:..|||:.:. :.:|| ....||||..   |.|:.:..:.|.:..|
Zfish   201 IDYNKLRKDDPMTNLNTAFDVAEKYLDIPK-MLDAEDIVGTARPDEKAIMTYVSSFYHAF 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	27/104 (26%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	21/111 (19%)
actn1	XP_005157053.1	CH	42..140	CDD:278723	27/104 (26%)
		CH	155..259	CDD:237981	28/142 (20%)
		Spectrin	284..394	CDD:278843
		SPEC	405..632	CDD:238103
		Spectrin	640..743	CDD:278843
		EFh	760..849	CDD:238008
		EF-hand_7	762..848	CDD:290234
		EFhand_Ca_insen	854..920	CDD:285885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910