DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and parvb

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_956020.1	Gene:	parvb / 325686	ZFINID:	ZDB-GENE-030131-4411	Length:	365	Species:	Danio rerio

Alignment Length:	367	Identity:	200/367 - (54%)
Similarity:	266/367 - (72%)	Gaps:	6/367 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLNRPKSPHTPTAIKKGEKEDSFWDKF-STLGRKRGTREVKKVQEEGKYAIDSPGSPSQYDIP 64
            |:| |..:|...|.   |.:|::|...|. .||.||:..:||..:|||||.||::|...:..::.
Zfish     1 MAT-NATRSTGQPA---KTKKDESLLGKLGGTLVRKKKIKEVSDLQEEGKNAINAPLLHTSPELL 61

  Fly    65 PEDYALREHEQRAVIDPQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWE 129
            |||..|.|:.:|.::||.|..|.....||::|:||||.||.|.||||:.||||:||||||.||:|
Zfish    62 PEDTLLEENAERTILDPTSREDLNFKDLQKVLIDWINSELEEDRIIVKDLEEDLYDGQVLQKLFE 126

  Fly   130 KLTGKKLDVPEVTQSEQGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVR 194
            ||:|.||:|.||||||.||.:||..||:|||..|.......:|||.|:||||:|:|::||:||..
Zfish   127 KLSGYKLNVAEVTQSEIGQKQKLQTVLEAVNGVLRPLDWNTEWSVDSIHSKNLVSIVYLLLALAI 191

  Fly   195 HFRAPVRLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGM-RCEKDAFDTLIDCAPDKLAV 258
            ::.||:||||:|.|.|::.:|..|:|......:|:||...::.: |.|:||||||:|.|||||.|
Zfish   192 YYAAPIRLPEHVSVQVIVVKKKEGILQTAHVTKQLTSTTTEMMIGRSERDAFDTLLDHAPDKLNV 256

  Fly   259 VKKSLITFVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQMVSNVA 323
            ||.||||||||||.|||.|:::|.|.|.|||||.||||||..:||||:.|:|||::.:|.|.|||
Zfish   257 VKTSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLENYFVPLYNFYLTPENFEQKVHNVA 321

  Fly   324 FAFDLMQDVGLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRD 365
            |||:||||.||.||||||||:||::|||||||||:|||.:::
Zfish   322 FAFELMQDGGLQKPKARPEDVVNLNLKSTLRVLYNLFTNYKN 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	61/99 (62%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	72/100 (72%)
parvb	NP_956020.1	CH	89..189	CDD:278723	61/99 (62%)
parvb	NP_956020.1	CH	256..357	CDD:278723	72/100 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578635
Domainoid	1	1.000	154	1.000	Domainoid score	I4212
eggNOG	1	0.900	-	-		E1_KOG3631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8342
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1875
OMA	1	1.010	-	-		QHG52959
OrthoDB	1	1.010	-	-		D373611at33208
OrthoFinder	1	1.000	-	-		FOG0002943
OrthoInspector	1	1.000	-	-		otm24706
orthoMCL	1	0.900	-	-		OOG6_105758
Panther	1	1.100	-	-	LDO	PTHR12114
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2710
SonicParanoid	1	1.000	-	-		X1944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800