DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and unc-70

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001256073.1	Gene:	unc-70 / 179077	WormBaseID:	WBGene00006803	Length:	2326	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	80/359 - (22%)
Similarity:	136/359 - (37%)	Gaps:	85/359 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 STLGRKRGTREVKKVQEEGKY-------------AIDSPGSPSQYDIPPEDYALREHEQRAV-ID 80
            |.|..|:..|:.|||...|.|             ..|...||:..::  .|....:....:| :.
Worm    37 SILKAKKSLRKTKKVASPGIYPGSAGALSSLSNGLADENRSPTSAEV--SDSVCGQKSINSVDLR 99

  Fly    81 PQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWEKLTGKKLDVPEVTQSE 145
            .:.:.|.:.:..::....|:|..|......||.|..||.||::|.:|...|:|::|  |:.|..:
Worm   100 FRGLRDERELVQKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLLAVLSGERL--PKPTPGK 162

  Fly   146 QGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVRHFRAPVRLPENVFVTV 210
            ...|     .|:.|...|.|.:.      ..||.:|:.:  |.:|      ....||...:..|:
Worm   163 MRIH-----CLENVEKGLQFLRN------QHVHLENLGS--HDIV------DGNSRLTLGLIWTI 208

  Fly   211 VIAEKNAGVLNAQKFQ-EQITSE-YDDLGMRCEKDAFDTLIDCAPDKLAVVKKSLITFVNKHLAK 273
            ::           :|| :.||.| .|:...|..|:|.  |:.|.               .|....
Worm   209 IL-----------RFQIQDITFEDADNHETRSAKEAL--LLWCQ---------------MKTAGY 245

  Fly   274 LNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQM-----VSNVAFAFDLMQD-V 332
            .|..:.:.:|.:|||:          .|...:|:......|.|.:     :.|:..|||..:: :
Worm   246 PNVNVKNFSTSWRDGL----------AFNALIHKHRPDLVDYDNLQKSNALYNLQSAFDTAENQL 300

  Fly   333 GLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRDF 366
            ||.| ....|| ||:|......::..:.|.:..|
Worm   301 GLAK-FLDAED-VNVDQPDEKSIITYVVTYYHYF 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	27/99 (27%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	22/106 (21%)
unc-70	NP_001256073.1	CH	110..208	CDD:278723	29/118 (25%)
		CH	229..333	CDD:237981	28/133 (21%)
		SPEC	368..580	CDD:238103
		SPEC	481..695	CDD:238103
		SPEC	698..908	CDD:238103
		SPEC	804..1014	CDD:238103
		SPEC	910..1120	CDD:238103
		SPEC	1122..1334	CDD:238103
		SPEC	1230..1439	CDD:238103
		SPEC	1440..1650	CDD:238103
		SPEC	1652..1864	CDD:238103
		SPEC	1865..2073	CDD:238103
		SPEC	2079..>2157	CDD:197544
		PH_beta_spectrin	2189..2290	CDD:269975
		PH	2190..2290	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910