DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment parvin and Parvb

DIOPT Version :9

Sequence 1:	NP_001285464.1	Gene:	parvin / 32990	FlyBaseID:	FBgn0052528	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_573395.1	Gene:	Parvb / 170736	MGIID:	2153063	Length:	365	Species:	Mus musculus

Alignment Length:	360	Identity:	216/360 - (60%)
Similarity:	268/360 - (74%)	Gaps:	3/360 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PKSPHTPTAIKKGEKEDSFWDKF-STLGRKRGTREVKKVQEEGKYAIDSPGSPSQYDIPPEDYAL 70
            |:|| ||.| .|.:|::||..|. .||.||:.||||..:|||||.||:||.:|:..||.|||..|
Mouse     6 PRSP-TPRA-PKMKKDESFLGKLGGTLARKKKTREVTDLQEEGKSAINSPMAPALVDIHPEDTQL 68

  Fly    71 REHEQRAVIDPQSISDPQVIKLQRILVDWINDELAEQRIIVQHLEEDMYDGQVLHKLWEKLTGKK 135
            .|:|:|.:|||.|..||:..:|.::|:|||||.|||:||||:.||||:||||||.||.|||...|
Mouse    69 EENEERTMIDPTSREDPKFKELVKVLLDWINDVLAEERIIVKQLEEDLYDGQVLQKLLEKLAHCK 133

  Fly   136 LDVPEVTQSEQGQHEKLNIVLKAVNHTLGFHQKIPKWSVASVHSKNIVAILHLLVALVRHFRAPV 200
            |:|.||||||.||.:||..||:||...|..|....:|:|.|:|.||:||||||||:|..|||||:
Mouse   134 LNVAEVTQSEIGQKQKLQTVLEAVQDLLRPHGWPLRWNVDSIHGKNLVAILHLLVSLAMHFRAPI 198

  Fly   201 RLPENVFVTVVIAEKNAGVLNAQKFQEQITSEYDDLGMRCEKDAFDTLIDCAPDKLAVVKKSLIT 265
            .|||:|.|.||:..|..|:|::....|::|:..:.:..|.|:||||||.|.|||||.:|||||||
Mouse   199 HLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNLVKKSLIT 263

  Fly   266 FVNKHLAKLNFEISDLNTDFRDGVYLCLLMGLLGGFFVPLHEFHLTPQDVDQMVSNVAFAFDLMQ 330
            ||||||.|||.|::||.|.|.|||||.||:|||..:|||||.|:|||...||.|.||||||:||.
Mouse   264 FVNKHLNKLNLEVTDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNVAFAFELML 328

  Fly   331 DVGLPKPKARPEDIVNMDLKSTLRVLYSLFTMFRD 365
            |.||.||||||||:||:||||||||||:|||.::|
Mouse   329 DGGLKKPKARPEDVVNLDLKSTLRVLYTLFTKYKD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
parvin	NP_001285464.1	CH	92..192	CDD:278723	62/99 (63%)
parvin	NP_001285464.1	CH	258..359	CDD:278723	74/100 (74%)
Parvb	NP_573395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		26/47 (55%)
		CH	89..190	CDD:278723	62/100 (62%)
		CH	257..357	CDD:278723	74/99 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835434
Domainoid	1	1.000	158	1.000	Domainoid score	I4115
eggNOG	1	0.900	-	-		E1_KOG3631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8342
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1873
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52959
OrthoDB	1	1.010	-	-		D373611at33208
OrthoFinder	1	1.000	-	-		FOG0002943
OrthoInspector	1	1.000	-	-		otm42893
orthoMCL	1	0.900	-	-		OOG6_105758
Panther	1	1.100	-	-	LDO	PTHR12114
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2710
SonicParanoid	1	1.000	-	-		X1944
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800