DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14234 and TMEM198

DIOPT Version :9

Sequence 1:	NP_001356951.1	Gene:	CG14234 / 32988	FlyBaseID:	FBgn0031065	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001005209.1	Gene:	TMEM198 / 130612	HGNCID:	33704	Length:	360	Species:	Homo sapiens

Alignment Length:	317	Identity:	82/317 - (25%)
Similarity:	145/317 - (45%)	Gaps:	57/317 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EPLAAILWAIFAVFGIVYALLGYRCLRAVGFLSGLLVGANGIFIL---QDFQITFLGKPADSALA 104
            :.|.|::..:..:||:||...||||.:||.||:|||.|:..||:|   :....|.|...|.:.:|
Human    35 QALPALVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIA 99

  Fly   105 IVAGLL-GAVLGSTYPVASVLISAFAGALLSGAAMAVCVATF-PDNEFGYREIYVAVVGGAVICS 167
            :..||| |.|......|...|:....|.||:.||:......: |.:.:|...:   ::||.::|:
Human   100 LGIGLLCGLVAMLVRSVGLFLVGLLLGLLLAAAALLGSAPYYQPGSVWGPLGL---LLGGGLLCA 161

  Fly   168 VLTLCCVKYVTILTSSIVGTAMILSAIDFFTHGLETINWII-GMRPHPSPPPCY-GGLLIAAWPV 230
            :|||...:.:|.|.:::.|.|:|.:|.|:|...|....::: .:|..|.||.|: ...|:|.||:
Human   162 LLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPL 226

  Fly   231 TIVLSIMVQCFITAWRVDHRKRVYMRHHNHPGHAHGAHLPHSQQQAGPNHGIAPVRRSQSRTRET 295
            ..::.::||..:||....|.:.|..|....                        |:..:.|.:|.
Human   227 LSLMGVLVQWRVTAEGDSHTEVVISRQRRR------------------------VQLMRIRQQED 267

  Fly   296 REEARQRK-----------------------FRYLYQVRTARGDIISQNFVSALQKR 329
            |:|.|::|                       .|....::...||::|.:::.:.:.|
Human   268 RKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRRRPVPIKRFNGDVLSPSYIQSFRDR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14234	NP_001356951.1	DUF4203	55..240	CDD:338988	62/191 (32%)
CG14234	NP_001356951.1	SelP_N	<249..288	CDD:335846	4/38 (11%)
TMEM198	NP_001005209.1	DUF4203	41..204	CDD:290597	52/165 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..304		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..360		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146876
Domainoid	1	1.000	92	1.000	Domainoid score	I7658
eggNOG	1	0.900	-	-		E1_28JN9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I5009
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45665
OrthoDB	1	1.010	-	-		D1509246at2759
OrthoFinder	1	1.000	-	-		FOG0003355
OrthoInspector	1	1.000	-	-		oto90302
orthoMCL	1	0.900	-	-		OOG6_105348
Panther	1	1.100	-	-	LDO	PTHR31247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6324
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800