DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and APL2

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_012787.1	Gene:	APL2 / 853723	SGDID:	S000001618	Length:	726	Species:	Saccharomyces cerevisiae

Alignment Length:	700	Identity:	251/700 - (35%)
Similarity:	418/700 - (59%)	Gaps:	40/700 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNY 76
            |||:.||::.|.:...:.:|:|:||.|..||:|||||:|||||:..:.|.::|.|||||||:|||
Yeast    25 KGELSELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNY 89

  Fly    77 AKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTA 141
            |::.|::.|:|||||:.|.:|.|||||.:|:|||..||||||.||:..|||:.|.|::.||||||
Yeast    90 AETHPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTA 154

  Fly   142 AVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTIN 206
            .:|||||:.::..:..:.|.::.|.:.|.||||:|:|||.|||.||:........|..:....::
Yeast   155 VICVAKLFQLNKDLCVELGVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVS 219

  Fly   207 KLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMKLLEML 271
            :.|.||||||||.::.||.:|:.||.||..|||.|.:|:|..|.|.|.||||:.:||:::.|..:
Yeast   220 QFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDRVTAHLQHVNPAVVLATIKVIVRNLPQI 284

  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVK 336
            ...|:  :.:.|:|:...|:|:|:.||:|||||:||.:|::|.|::|..|:::|:||:|||:|||
Yeast   285 EYSSN--SLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVK 347

  Fly   337 LEKLDIMIRLANQSNIAQ---VLSELKEYATEVDVDFVRKAVRAIGRCAIKV--EPSAERCVSTL 396
            |||:||::||.:.||:.|   :|:||||||.|.:.:||.:|::|:.:..||.  |....:.:..|
Yeast   348 LEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQLGIKYAQESFVSKVLDIL 412

  Fly   397 LDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPE-------ARASMVWIIG 454
            |:|:: :.:.:..:..:.:.|:.|..|.. :.:...:|...:|...||       |:.:.||::|
Yeast   413 LELLE-RQDTIKDDCCISLCDLLRHCPGN-DKMAKQVCAVFNTWSNPEVLLQSDIAKCNYVWLLG 475

  Fly   455 EYAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPD 519
            ::.....:.:..::.|:|.|..|.|..|:.||..:|:|   ..:.|..::|.||.||||.:...|
Yeast   476 QHPNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRL---HATLTGSMLQSVLELATQQTHELD 537

  Fly   520 LRDRGFIYWRLLS--TDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPT-- 580
            :||...:|||.||  .:.:...::.....|:||...:...|.:|::|:..:.:::|:|.||.:
Yeast   538 VRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGTISSIYFKPDSNR 602

  Fly   581 --------AFVEGRGAGVRKSLPNRAAGSAAG------AEQAENAAGSEAMVIPNQESLIGDLLS 631
                    ..|:|:.....:|:......|.|.      .::.::...:.|.:: |..:.:|||..
Yeast   603 RKGKKYVQNIVKGKHIEELESMAKNEISSKANDDVLLDFDERDDVTNTNAGML-NTLTTLGDLDD 666

  Fly   632 MDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLLGDIFG 681
            :....|:..:....|::...:.|..::.|||.....:.||..:  .|:.|
Yeast   667 LFDFGPSEDATQINTNDTKAVQGLKELKLGGDSNGISSGGKNN--PDVSG 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	211/510 (41%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	16/26 (62%)
		Cnd1	99..269	CDD:289487	81/169 (48%)
		HEAT repeat	121..151	CDD:293787	17/29 (59%)
		HEAT repeat	160..186	CDD:293787	14/25 (56%)
		HEAT repeat	197..229	CDD:293787	13/31 (42%)
		HEAT repeat	393..417	CDD:293787	3/23 (13%)
		HEAT repeat	429..458	CDD:293787	8/35 (23%)
		HEAT repeat	465..495	CDD:293787	10/29 (34%)
		HEAT repeat	506..542	CDD:293787	14/37 (38%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
APL2	NP_012787.1	COG5096	6..726	CDD:227427	250/699 (36%)
		HEAT repeat	64..88	CDD:293787	13/23 (57%)
		HEAT repeat	100..127	CDD:293787	16/26 (62%)
		HEAT repeat	134..164	CDD:293787	17/29 (59%)
		HEAT repeat	173..199	CDD:293787	14/25 (56%)
		HEAT repeat	214..242	CDD:293787	12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I76
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I250
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		oto99434
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
TreeFam	1	0.960	-	-
	13	12.860