Protein Alignment AP-1-2beta and APL2

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_012787.1
• Gene: APL2 / 853723
• SGDID: S000001618
• Length: 726
• Species: Saccharomyces cerevisiae
• Alignment Length: 700
• Identity: 251/700 - (35%)
• Similarity: 418/700 - (59%)
• Gaps: 40/700 - (5%)

  Fly    12 KGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNY 76
            |||:.||::.|.:...:.:|:|:||.|..||:|||||:|||||:..:.|.::|.|||||||:|||
Yeast    25 KGELSELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNY 89

  Fly    77 AKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTA 141
            |::.|::.|:|||||:.|.:|.|||||.:|:|||..||||||.||:..|||:.|.|::.||||||
Yeast    90 AETHPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTA 154

  Fly   142 AVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTIN 206
            .:|||||:.::..:..:.|.::.|.:.|.||||:|:|||.|||.||:........|..:....::
Yeast   155 VICVAKLFQLNKDLCVELGVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVS 219

  Fly   207 KLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMKLLEML 271
            :.|.||||||||.::.||.:|:.||.||..|||.|.:|:|..|.|.|.||||:.:||:::.|..:
Yeast   220 QFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDRVTAHLQHVNPAVVLATIKVIVRNLPQI 284

  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVK 336
            ...|:  :.:.|:|:...|:|:|:.||:|||||:||.:|::|.|::|..|:::|:||:|||:|||
Yeast   285 EYSSN--SLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVK 347

  Fly   337 LEKLDIMIRLANQSNIAQ---VLSELKEYATEVDVDFVRKAVRAIGRCAIKV--EPSAERCVSTL 396
            |||:||::||.:.||:.|   :|:||||||.|.:.:||.:|::|:.:..||.  |....:.:..|
Yeast   348 LEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQLGIKYAQESFVSKVLDIL 412

  Fly   397 LDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPE-------ARASMVWIIG 454
            |:|:: :.:.:..:..:.:.|:.|..|.. :.:...:|...:|...||       |:.:.||::|
Yeast   413 LELLE-RQDTIKDDCCISLCDLLRHCPGN-DKMAKQVCAVFNTWSNPEVLLQSDIAKCNYVWLLG 475

  Fly   455 EYAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPD 519
            ::.....:.:..::.|:|.|..|.|..|:.||..:|:|   ..:.|..::|.||.||||.:...|
Yeast   476 QHPNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRL---HATLTGSMLQSVLELATQQTHELD 537

  Fly   520 LRDRGFIYWRLLS--TDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPT-- 580
            :||...:|||.||  .:.:...::.....|:||...:...|.:|::|:..:.:::|:|.||.:
Yeast   538 VRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGTISSIYFKPDSNR 602

  Fly   581 --------AFVEGRGAGVRKSLPNRAAGSAAG------AEQAENAAGSEAMVIPNQESLIGDLLS 631
                    ..|:|:.....:|:......|.|.      .::.::...:.|.:: |..:.:|||..
Yeast   603 RKGKKYVQNIVKGKHIEELESMAKNEISSKANDDVLLDFDERDDVTNTNAGML-NTLTTLGDLDD 666

  Fly   632 MDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLLGDIFG 681
            :....|:..:....|::...:.|..::.|||.....:.||..:  .|:.|
Yeast   667 LFDFGPSEDATQINTNDTKAVQGLKELKLGGDSNGISSGGKNN--PDVSG 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	211/510 (41%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	16/26 (62%)
		HEAT repeat	121..151	CDD:293787	17/29 (59%)
		HEAT repeat	160..186	CDD:293787	14/25 (56%)
		HEAT repeat	197..229	CDD:293787	13/31 (42%)
		HEAT repeat	393..417	CDD:293787	3/23 (13%)
		HEAT repeat	429..458	CDD:293787	8/35 (23%)
		HEAT repeat	465..495	CDD:293787	10/29 (34%)
		HEAT repeat	506..542	CDD:293787	14/37 (38%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
APL2	NP_012787.1	COG5096	6..726	CDD:227427	250/699 (36%)
		HEAT repeat	64..88	CDD:293787	13/23 (57%)
		HEAT repeat	100..127	CDD:293787	16/26 (62%)
		HEAT repeat	134..164	CDD:293787	17/29 (59%)
		HEAT repeat	173..199	CDD:293787	14/25 (56%)
		HEAT repeat	214..242	CDD:293787	12/27 (44%)