DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and APL1

DIOPT Version :9

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_012538.3 Gene:APL1 / 853461 SGDID:S000003765 Length:700 Species:Saccharomyces cerevisiae


Alignment Length:605 Identity:191/605 - (31%)
Similarity:336/605 - (55%) Gaps:36/605 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTDSKYFTTTKKGEI------FELKSELNNDKKEKKKEAVKKVIASMTVGK--DVSALFPDVVNC 57
            |:|.|.|...|..||      |.:|...:|  ..::|.|::|:||::.:|.  ::|.||.:::..
Yeast     1 MSDQKVFARYKANEIVTDLQHFGVKKFKSN--ITRRKNALRKIIANLVLGNYGEMSVLFSELLKF 63

  Fly    58 MQ-TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEY 121
            .| .|:||:|::.:.|:......:|..|..|:...:.|.:..:..::.:|:||:..:.|.::::.
Yeast    64 WQIEDDLEVKRICHEYIRVIGALKPQQAREALPFIMDDFKSRDEKLQIMALRTLVLVPVKELSDQ 128

  Fly   122 LCEPLRKCLKDEDP--YVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLL--SDSNPMVVANAVA 182
            ..:.:...:..:.|  .|.:||...:..|.:|....|  .|....|.|::  ..|:|.|:..|:.
Yeast   129 AFDCIISLVNHKSPPEQVTRTAIYALLDLDEIDHERV--LGLSSILHDIVKAQSSSPEVIVAALH 191

  Fly   183 ALSEINEASQSGQPLVEMNSVTINKLLTALNECTEWGQVFILDSL-ANYSPKDEREAQSICERIT 246
            .|..|:|.:.:.:|......:..: :|..|.|..||.:..:|:.| .:..|:...:...:.|...
Yeast   192 TLYSIHEKNANMEPFRIPLELAFD-MLELLPELNEWNKATVLEVLTTSVVPQHYLDTHEMIELAL 255

  Fly   247 PRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRN-INLI 310
            |.|...|..|||:::|.:|.||..:....:   ||.:||:..::.||...||:|::.||| |.|:
Yeast   256 PYLQQVNTYVVLNSLKFIMYLLNYVDVIKE---TLAEKLSNSVIALLDKPPELQFLVLRNVILLL 317

  Fly   311 VQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAV 375
            :.:...:|:.::..||::||||||:|..||:.:..|||:..:.::|.||::|||::|:...||:|
Yeast   318 LSRESSLLRLDISYFFIEYNDPIYIKDTKLECLYLLANKETLPRILEELEQYATDIDIQMSRKSV 382

  Fly   376 RAIGRCAIKV-EPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDT 439
            ||||..|:|: |.|...||:.||||::..|:|||||.|.|.::|.|||||.:::.::.|.::.:.
Yeast   383 RAIGNLAVKLDEDSVHDCVAVLLDLLEFGVDYVVQEIISVFRNILRKYPNNFKANVTELVKHTEV 447

  Fly   440 LDEPEARASMVWIIGEYAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPS-DTQEL 503
            :.|||::.:|:|||.:|::.|.|..||...|......|..:||..:|.:.:|.|::.|: :|:||
Yeast   448 VQEPESKNAMIWIITQYSDVIPNYLELFRVFSSNMFSETLEVQFSILNSAIKFFIRSPTKETEEL 512

  Fly   504 VQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPA----------AAKEVVLADKPLISEETDLLEP 558
            ...:|.......:||||||:..:||||||....          :.|.|:..:.|||...|. |:|
Yeast   513 CMDLLKGCIDHENNPDLRDKTLMYWRLLSLTKTSRISNAITFESLKSVLDGELPLIEMNTK-LDP 576

  Fly   559 TLLDELICHISSLASVYHKP 578
            |:|:||..:|.::.|:|.||
Yeast   577 TVLEELELNIGTIVSIYLKP 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 161/507 (32%)
HEAT repeat 51..75 CDD:293787 7/24 (29%)
HEAT repeat 87..114 CDD:293787 5/26 (19%)
Cnd1 99..269 CDD:289487 40/174 (23%)
HEAT repeat 121..151 CDD:293787 5/31 (16%)
HEAT repeat 160..186 CDD:293787 8/27 (30%)
HEAT repeat 197..229 CDD:293787 7/32 (22%)
HEAT repeat 393..417 CDD:293787 13/23 (57%)
HEAT repeat 429..458 CDD:293787 9/28 (32%)
HEAT repeat 465..495 CDD:293787 9/29 (31%)
HEAT repeat 506..542 CDD:293787 14/45 (31%)
Alpha_adaptinC2 703..799 CDD:197886
B2-adapt-app_C 809..919 CDD:198088
APL1NP_012538.3 COG5096 1..700 CDD:227427 191/605 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5096
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53641
OrthoFinder 1 1.000 - - FOG0001621
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100684
Panther 1 1.100 - - O PTHR11134
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.780

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