DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and APL6

DIOPT Version :10

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_011777.3 Gene:APL6 / 853177 SGDID:S000003493 Length:809 Species:Saccharomyces cerevisiae


Alignment Length:610 Identity:137/610 - (22%)
Similarity:264/610 - (43%) Gaps:105/610 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TTKKGEIF-----------ELKSELNNDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
            |:|.||..           :|.:.||:....:.::|:|::|:.|....   ||...|.|||..:.
Yeast    27 TSKLGESSYTYYSQNINPQQLVTLLNSRNSREVRDAMKRIISIMASDDDSIDVQLYFADVVKNIT 91

  Fly    60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCE 124
            |::.::|:|::|||:.:|::.|::.::::|:..|...|||..:|..|:..:..:::..:...:..
Yeast    92 TNDTKVKRLIHLYLLRFAENDPNLTLLSINSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILH 156

  Fly   125 PLRKCLKDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINE 189
            .::|.:.|....||...|:.:.|||........:: .||.||:|::|::|.|::.||.|..|...
Yeast   157 TVKKLVTDPSAMVRGEVALAIIKLYRAGKNDYHEE-LLDILKELMADTDPKVISCAVLAYKECYA 220

  Fly   190 ASQSGQPLVEMNSVTINKLLTALNECTEWGQVFILDSLANY-----------------SPK---- 233
            ..      :|:......:....:.:...|.|.::::.|..|                 ||:    
Yeast   221 DH------LELLHGHFRRYCRIIKQLDSWSQSYLIELLIKYCKQYLPKPTVVDKSSEGSPRSCPL 279

  Fly   234 ---------------DEREAQSICERITPRLAHANAAVVLSAVKVLMKLLEMLS-SDSDFCATLT 282
                           ::.:.....:.:...:..:|..|:||....|.:|...|. .::.|...|.
Yeast   280 PDKYNEIEYPSYEVVNDPDLDLFLQSLNCLIYSSNPTVILSCCNALYQLASPLQMKNTKFIEALV 344

  Fly   283 KKLAPPLVTLLSSE--PEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIR 345
            :     .||:..::  .|:...|:..::::.|   .:.....|.|:|...|||...:.|:.|:..
Yeast   345 R-----TVTMTENQGNKEMLLQAIHFLSILDQ---TLFLPYTKKFYVFPKDPIVASIWKIQILST 401

  Fly   346 LANQSNIAQVLSELKEYATEVDV--DFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQT-KVNYV 407
            |.|:||:.::..|||.|......  :.|..||:::.||...........:..|:|.::: .::..
Yeast   402 LINESNVKEIFKELKYYVASAHFPENVVIMAVKSLSRCGQLSTSWESHVMKWLIDHMESHNLSAS 466

  Fly   408 VQEAIV-VIKDIFRKYPNKYESIISTLCE--NLDTLDEPEARASMVWIIGEYAE-RIDNADELLD 468
            |.:|.| ||:.:.:|.|.|:..||..|.:  .:.|.....|||.:||:.||.|. ......::|.
Yeast   467 VLDAYVNVIRMLVQKNPTKHLRIIFKLADLLTVQTSLADNARAGIVWLFGEIASIEFKICPDVLR 531

  Fly   469 SFLEGFQDENAQVQLQLLTAVVKLFL------------------KRP-------SDTQELVQHVL 508
            ..::.|.:|..:.:.|:|....||..                  :.|       |...::...||
Yeast   532 RLIQNFSNEGPETRCQILVLSAKLLSYDIDNFKQAQVTGSEENNQNPPYYDFSGSRISQMYNAVL 596

  Fly   509 SLATQDSDNPDLRDRGFIYWRLLST 533
            .||..| |..|:|||.    |::|:
Yeast   597 YLAKYD-DEFDIRDRA----RMISS 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 128/570 (22%)
HEAT repeat 51..75 CDD:293787 10/23 (43%)
HEAT repeat 87..114 CDD:293787 7/26 (27%)
HEAT repeat 121..151 CDD:293787 8/29 (28%)
HEAT repeat 160..186 CDD:293787 11/25 (44%)
HEAT repeat 197..229 CDD:293787 4/31 (13%)
HEAT repeat 393..417 CDD:293787 7/25 (28%)
HEAT repeat 429..458 CDD:293787 11/30 (37%)
HEAT repeat 465..495 CDD:293787 7/47 (15%)
HEAT repeat 506..542 CDD:293787 12/28 (43%)
Alpha_adaptinC2 703..799 CDD:197886
B2-adapt-app_C 809..919 CDD:198088
APL6NP_011777.3 COG5096 6..770 CDD:227427 137/610 (22%)
HEAT repeat 45..69 CDD:293787 6/23 (26%)
HEAT repeat 119..146 CDD:293787 7/26 (27%)
HEAT repeat 153..182 CDD:293787 7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

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