DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1-2beta and AT5G11490

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001190290.1	Gene:	AT5G11490 / 831021	AraportID:	AT5G11490	Length:	850	Species:	Arabidopsis thaliana

Alignment Length:	837	Identity:	260/837 - (31%)
Similarity:	416/837 - (49%)	Gaps:	113/837 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KGEIFELKSELNN-------DKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLV 69
            |.|:.:||::|..       ...:.|::..||||:.||:|.|||::|.::|.|..|.::.|||:.
plant    19 KSEVSDLKTQLRQLAGSRAPGVDDSKRDLYKKVISYMTIGIDVSSVFGEMVMCSATSDIVLKKMC 83

  Fly    70 YLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
            |||:.||||..||::::.:|...:||:|.:|:||.||:|::..:||..:.|||..||...|||.:
plant    84 YLYVGNYAKGNPDLSLLTINFLQRDCKDEDPMIRGLALRSLCSLRVPNLVEYLVGPLGSGLKDNN 148

  Fly   135 PYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDL-LSDSNPMVVANAVAALSEI--NEASQSGQP 196
            .|||..|...|.|||.||.:...|..|...||.| |.||:..||||.::||.||  .|||.|.:.
plant   149 SYVRTIAVTGVLKLYHISPSTCIDADFPATLKSLMLHDSDAQVVANCLSALQEIWSLEASHSEEA 213

  Fly   197 LVEMNSV----TINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVV 257
            ..|..|:    .|...|..:.|..||.|..||:....|.|.|..:...|...:..||.|||.|||
plant   214 CREKESLLSKPVIYYFLNRIKEFNEWAQCLILELAVKYVPSDSNDIFDIMNLLEDRLQHANGAVV 278

  Fly   258 LSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSS-EPEVQYVALRNINLIVQKRPDILKHE 321
            |:.|||   .|::..|.:|....:.:::..||:||:|| .||..|..|.:::|:|.:.|.|...:
plant   279 LATVKV---FLQLTLSMTDVHQQVYERIKSPLLTLVSSGSPEQSYAILSHLHLLVVRAPFIFAAD 340

  Fly   322 MKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVE 386
            .|.|:.:||:|.|||..||:::..:||:||..::::||.|||..||:...|:::||:|:.|:: :
plant   341 YKHFYCQYNEPSYVKKLKLEMLTAVANESNTYEIVTELCEYAANVDIAIARESIRAVGKIALQ-Q 404

  Fly   387 PSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTL----CENLDTLDEPEARA 447
            ......|..||..::.:.:||..|.:|::||:.||||......||.:    .:|   :.||:|:|
plant   405 YDVNAIVDRLLQFLEMEKDYVTAETLVLVKDLLRKYPQWSHDCISVVGGISSKN---IQEPKAKA 466

  Fly   448 SMVWIIGEYAERIDNADELLDSFLEGFQDE-NAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLA 511
            :::|::||||:.:.:|..:|::.:|.:::| :|:|:|.||||.:|.|.||..:||:.:...|:..
plant   467 ALIWMLGEYAQDMSDAPYVLENLIENWEEEHSAEVRLHLLTAAMKCFFKRAPETQKALGTALAAG 531

  Fly   512 TQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYH 576
            ..|. :.|:.||...|:|:|..|...|:.||...|..:|...|.....:.|.:....:||:.:|.
plant   532 IADF-HQDVHDRALFYYRVLQYDVHVAERVVSPPKQAVSVFADTQSSEIKDRVFDEFNSLSVIYQ 595

  Fly   577 KPPTAFVEGRGAGVRK--------SLPNRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMD 633
            ||...|.:....|..:        |:...|:.....|:|.|          .|.:.|:..:...|
plant   596 KPSYMFTDKEHRGPFEFSDEVGNISITPEASSDIVPAQQYE----------ANDKDLLLGIDEKD 650

  Fly   634 IN------------APAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLLGDIFGLGGAT 686
            .|            ||::.|:...||.:.      ::.:.| ||.:|....:....|:||||.:|
plant   651 ENKGVSNNNGSAYTAPSLESSSNITSQMQ------ELAISG-PATSATTPQSFGFDDLFGLGLST 708

  Fly   687 LSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLVPA 751
            .......|.:..|.|.....   .|.|.::..:  :.::||.:.                   ..
plant   709 APAPTPSPPLLKLNARAALD---PGAFQQKWRQ--LPISLTQEC-------------------SV 749

  Fly   752 SPMQAAPLPPNQSIEVSM--------ALGTNGPIQRMEPLNNLQVAVKNNIDIFYFA 800
            :|...|.|...||:...|        |.|...|                |...|:||
plant   750 NPQGIAALTVPQSLIKHMQSHSIHCIASGGQSP----------------NFKFFFFA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	192/509 (38%)
		HEAT repeat	51..75	CDD:293787	10/23 (43%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	72/176 (41%)
		HEAT repeat	121..151	CDD:293787	15/29 (52%)
		HEAT repeat	160..186	CDD:293787	13/26 (50%)
		HEAT repeat	197..229	CDD:293787	10/35 (29%)
		HEAT repeat	393..417	CDD:293787	7/23 (30%)
		HEAT repeat	429..458	CDD:293787	11/32 (34%)
		HEAT repeat	465..495	CDD:293787	12/30 (40%)
		HEAT repeat	506..542	CDD:293787	10/35 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	15/103 (15%)
		B2-adapt-app_C	809..919	CDD:198088
AT5G11490	NP_001190290.1	Adaptin_N	41..551	CDD:279882	195/517 (38%)
		HEAT repeat	101..129	CDD:293787	10/27 (37%)
		Cnd1	113..288	CDD:289487	73/177 (41%)
		HEAT repeat	135..165	CDD:293787	15/29 (52%)
		HEAT repeat	174..201	CDD:293787	13/26 (50%)
		B2-adapt-app_C	727..836	CDD:198088	17/104 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820