DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and AP3B2

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001265441.1	Gene:	AP3B2 / 8120	HGNCID:	567	Length:	1101	Species:	Homo sapiens

Alignment Length:	1131	Identity:	282/1131 - (24%)
Similarity:	463/1131 - (40%)	Gaps:	281/1131 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSKYFTTTKKGEIF--------ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQ 59
            :.:|......|.||        :||..|:.:|...|.||:|:::|.:..||:.|.|||.||..:.
Human    19 EPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA 83

  Fly    60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCE 124
            ..|:|:|||||:||:.||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:..
Human    84 CKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMML 148

  Fly   125 PLRKCLKDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINE 189
            .:::...|..||||||||..:.|||.:.:.. :|| .::.::.||:|...:|..:.|.|..|:..
Human   149 AIKEAASDMSPYVRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCP 211

  Fly   190 ASQSGQPLVEMNSVTINKLLTALNECTEWGQVFILDSLANY------SP---------------- 232
            ..      :::......||...|.:..|||||.|:..|..|      ||
Human   212 ER------IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFY 270

  Fly   233 -KDEREAQS-------------------------ICERITPRLAHANAAVVLSAVKVLMKLLEML 271
             .:|.||:.                         :.....|.|...:||||::..::...|....
Human   271 GSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKA 335

  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVK 336
            .         ...:|..||.||.|..|||||.|:|:..:..||..:.:..:|.|:::..||..:|
Human   336 E---------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIK 391

  Fly   337 LEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQ 401
            :.||:::..|||::||..||.|.:.|...:|.|||...::||||||..:....:.|::.|:.|:.
Human   392 ILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLS 456

  Fly   402 TKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADE 465
            .:...||.|::||||.:.:..|.::..||..|.:..|.:..|.||||::|:||||.|.:.. |.:
Human   457 NRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPD 521

  Fly   466 LLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIYWRL 530
            :|....:.|..|...|:||::....||:|.....|:.|.|:|||||..| .|.|:|||.....:|
Human   522 VLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QNYDIRDRARFTRQL 585

  Fly   531 L--STDPAA----AKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVE----- 584
            :  |....|    ||::.||.||     ..:||.:..|.....:.||:.:.:...|.:.|
Human   586 IVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWP 645

  Fly   585 ----------------------------------------------------------------- 584

Human   646 EEAPDPSVRNVEEEDLSLIETHVGLLGEYTEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESA 710

  Fly   585 --------------------------------------GRGA--------GVRKS---LPNR--- 597
                                                  |||:        |.||:   :|.|
Human   711 DSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGE 775

  Fly   598 AAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGG 662
            |:.|..|::.:.:::.|| |...::|..:..........|:..||| ||..:.|    ||:....
Human   776 ASSSDEGSDSSSSSSESE-MTSESEEEQLEPASWSRKTPPSSKSAP-ATKEISL----LDLEDFT 834

  Fly   663 PPA--EAAPGG--ATSLLGDIFGLGGATLSVGVQIPKV----------TWLPAEKGKGLEIQGTF 713
            ||:  ..:|..  :|||..|:.||   ||:....:|.:          ..|....|:||.:..||
Human   835 PPSVQPVSPPAIVSTSLAADLEGL---TLTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTF 896

  Fly   714 SRR--NGE---VFMDMTLTNKAMQPMTNFAIQLNKNSFGLVPASPMQAAPLPPNQSIEVSMALGT 773
            ||:  :|:   |.:.:..:|.:..|:....:...|...|:......:...|.|.:|....|.:..
Human   897 SRQPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINF 961

  Fly   774 NGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDGQLDKRVFL--NTWK----EIPAANE 832
            ....|..    |.|:..:..  .||.:       :....|:|...||:  |.:|    ::...||
Human   962 CDSTQAA----NFQLCTQTR--QFYVS-------IQPPVGELMAPVFMSENEFKKEQGKLMGMNE 1013

  Fly   833 L--QYTLSGVIGTTDGIASKMT-----------TNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLL 884
            :  :..|.....:...:..|:|           |::.:..|.|.:.|..:            |||
Human  1014 ITEKLMLPDTCRSDHIVVQKVTATANLGRVPCGTSDEYRFAGRTLTGGSL------------VLL 1066

  Fly   885 ELKLQPGNPEATLSLKSRSVEVANII 910
            .|..:|.. .|.|::.|..:.:..::
Human  1067 TLDARPAG-AAQLTVNSEKMVIGTML 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	174/547 (32%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	55/217 (25%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	10/31 (32%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	14/28 (50%)
		HEAT repeat	465..495	CDD:293787	8/29 (28%)
		HEAT repeat	506..542	CDD:293787	16/41 (39%)
		Alpha_adaptinC2	703..799	CDD:197886	21/100 (21%)
		B2-adapt-app_C	809..919	CDD:198088	23/121 (19%)
AP3B2	NP_001265441.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		1/10 (10%)
		Adaptin_N	34..590	CDD:279882	181/573 (32%)
		HEAT repeat	111..139	CDD:293787	11/27 (41%)
		Cnd1	123..267	CDD:289487	45/151 (30%)
		HEAT repeat	145..173	CDD:293787	10/27 (37%)
		HEAT repeat	182..208	CDD:293787	7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..295		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..821		19/137 (14%)
		AP3B1_C	823..966	CDD:291462	33/149 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820