DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and Ap2b1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001030931.1	Gene:	Ap2b1 / 71770	MGIID:	1919020	Length:	951	Species:	Mus musculus

Alignment Length:	958	Identity:	691/958 - (72%)
Similarity:	789/958 - (82%)	Gaps:	45/958 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||.|||||||||:||||:||||:|||||||||:||||||||:||||||||||||||||
Mouse     1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||:|||||||.||||||||||||||||||||||||||||||||
Mouse    66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.|||||||||.|:||::|||||||||||||||||:| |....
Mouse   131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISE-SHPNS 194

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|:::|...||||||||||||||||:||||.|:||:|||:|||||||||:||||:|||:||||||
Mouse   195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.||:|..|||:...|.||||||||||||.||||||||||||||||||||:|||.|:|||
Mouse   260 VKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
Mouse   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            |||||||||||||||||||||||||:||||||||||||||:|||||||:||||:|||:|:||:||
Mouse   390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.||||.||||:||||||:||:||||||.||||||||||||||
Mouse   455 YAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||..||||||::||||||||||:||||||||||||.||||||||||.|||||
Mouse   520 RDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLP-----NRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            .....||.||     ..|..|..|.....|.  .:..|||:|..|:||||::|:..|.  :.|..
Mouse   585 SHGIHRKHLPIHHGSTDAGDSPVGTTTTTNL--EQPQVIPSQGDLLGDLLNLDLGPPV--NVPQV 645

  Fly   646 TS----NVDLLGGGLDILL--------GGPPA----------------EAAPGGATSLLGDIF-- 680
            :|    .|||||||||.||        ||.||                ...|...:|.|.|:|
Mouse   646 SSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFEL 710

  Fly   681 --GLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNK 743
              |:|.|  ..|...||..||||.|.|||||.|||:.|.|.::|:|..||||:|.||:||||.||
Mouse   711 STGIGMA--PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNK 773

  Fly   744 NSFGLVPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNV 807
            ||||::|::|:.. .||.|||||:||:.|.|.||:.:||||||||||||||||:|||:||:..||
Mouse   774 NSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNV 838

  Fly   808 LFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQ 872
            ||.|||:::::|||.|||:||..||||:.:.......|.::||:..||::|||||||||||||||
Mouse   839 LFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQ 903

  Fly   873 SLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920
            ||||||.||:|.||::|||||..|||||.|:.||:..|:..|::|:::
Mouse   904 SLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	430/496 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		Cnd1	99..269	CDD:289487	140/169 (83%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	23/29 (79%)
		HEAT repeat	506..542	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	703..799	CDD:197886	62/96 (65%)
		B2-adapt-app_C	809..919	CDD:198088	63/109 (58%)
Ap2b1	NP_001030931.1	Adaptin_N	11..534	CDD:396262	454/523 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	392..416	CDD:293787	23/23 (100%)
		HEAT repeat	428..457	CDD:293787	22/28 (79%)
		HEAT repeat	464..494	CDD:293787	23/29 (79%)
		HEAT repeat	505..541	CDD:293787	31/35 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..617		6/25 (24%)
		Alpha_adaptinC2	731..831	CDD:197886	64/99 (65%)
		B2-adapt-app_C	840..950	CDD:198088	63/109 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	905	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1350	1.000	Inparanoid score	I141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm43119
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	O	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870