DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and Copb1

DIOPT Version :9

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_203534.1 Gene:Copb1 / 70349 MGIID:1917599 Length:953 Species:Mus musculus


Alignment Length:1050 Identity:204/1050 - (19%)
Similarity:365/1050 - (34%) Gaps:324/1050 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNYAKSQP 81
            ||::|.....:.|.||:||||..:..|:.:..|...::. .:...:..:|||:.::.....|:.|
Mouse    26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTP 90

  Fly    82 D-----MAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTA 141
            |     ..|:..:.:.||.:..|..||...:|.:..::..::.|.|...:|.||:....|||:.|
Mouse    91 DGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNA 155

  Fly   142 AVCVAKLYDISATMVED-----QGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMN 201
            .:.:..:|.....::.|     ..||...||.....|         |...:..|.|         
Mouse   156 VLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRN---------AFMMLIHADQ--------- 202

  Fly   202 SVTINKLLTALNECTEWGQVF--ILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVL 264
                ::.|..|:.|.:..|.|  ||              |.:...:..::.|||.:.....::.:
Mouse   203 ----DRALDYLSTCIDQVQTFGDIL--------------QLVIVELIYKVCHANPSERARFIRCI 249

  Fly   265 MKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQ-----YVAL------RNINLIVQKRPDIL 318
            ..||:..|      ..:..:.|..||||.|:...::     |:.|      .|:.|||..|...|
Mouse   250 YNLLQSSS------PAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVEL 308

  Fly   319 K----HE-------MKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEV------ 366
            |    ||       |.:..|.....:.|:.:.|.:.:.|.:..|:.:::..||:...:.      
Mouse   309 KEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEH 373

  Fly   367 -DVDFVRK-AVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESI 429
             |.|..|: .||.:..|:::....|...:..|::.:.........:.:..:::..:::.|....|
Mouse   374 EDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLI 438

  Fly   430 ISTLCENLDTLDEPEARASMVWIIGEYAERIDNADELLDSFLEGFQDENAQVQLQL-LTAVVKLF 493
            :..:.|....:...:.....:||:|||.           |..|..|....:|:..| ...:|:..
Mouse   439 VEKMLEVFHAIKSVKIYRGALWILGEYC-----------STKEDIQSVMTEVRRSLGEIPIVESE 492

  Fly   494 LK------RPSD------TQELVQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADK 546
            :|      :|.:      .|:||..:.:.|||.:              |.|:.|...:|    |:
Mouse   493 IKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA--------------LSSSRPTKKEE----DR 539

  Fly   547 PLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRKSLPNRAAGSAAGAEQAENA 611
            |       .|...|||......:|||:...|....:|                 :....::.:|:
Mouse   540 P-------PLRGFLLDGDFFVAASLATTLTKIALRYV-----------------ALVQEKKKQNS 580

  Fly   612 AGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLL 676
            ..:|||:      |:..:|  .:...::|..|....:||.:...|.:|     :|.:|     |:
Mouse   581 FVAEAML------LMATIL--HLGKSSLPKKPITDDDVDRISLCLKVL-----SECSP-----LM 627

  Fly   677 GDIFGLG-----GATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTN-------- 728
            .|||...     ...||..::..|::.....:.:.:.:|..    :...||.:|..|        
Mouse   628 NDIFNKECRQSLSQMLSAKLEEEKLSQKKESEKRNVTVQPD----DPISFMQLTAKNEMNCKEDQ 688

  Fly   729 ---------------KAMQPMTNFAIQLNK-------------------NSFGLVPASPMQAAPL 759
                           :|..|:   |.:|||                   |.:.:|      ...|
Mouse   689 FQLSLLAAMGNTQRKEAADPL---ASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV------LDVL 744

  Fly   760 PPNQSIEV----SMALGTNGPIQRME---PLN-----------NLQVAVKNNIDIFYFACLVHGN 806
            ..||:.:.    ::.|.|.|.::.:|   ||.           |::||...|..||       ||
Mouse   745 VVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIF-------GN 802

  Fly   807 VLFAEDGQLDKR------------------------VFLNTWKEIPAANELQYTLSGVIGTTDGI 847
            :::...|....|                        .|...|.|....|                
Mouse   803 IVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWEN---------------- 851

  Fly   848 ASKMTTNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLS---------LKSRS 903
              |:|.|...|      :..|.|...||.||         ::...||..||         |.:||
Mouse   852 --KVTVNTNMT------DLNDYLQHILKSTN---------MKCLTPEKALSGYCGFMAANLYARS 899

  Fly   904 V----EVANI 909
            :    .:||:
Mouse   900 IFGEDALANV 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 106/552 (19%)
HEAT repeat 51..75 CDD:293787 3/24 (13%)
HEAT repeat 87..114 CDD:293787 6/26 (23%)
Cnd1 99..269 CDD:289487 35/176 (20%)
HEAT repeat 121..151 CDD:293787 9/29 (31%)
HEAT repeat 160..186 CDD:293787 6/25 (24%)
HEAT repeat 197..229 CDD:293787 7/33 (21%)
HEAT repeat 393..417 CDD:293787 1/23 (4%)
HEAT repeat 429..458 CDD:293787 7/28 (25%)
HEAT repeat 465..495 CDD:293787 6/30 (20%)
HEAT repeat 506..542 CDD:293787 7/35 (20%)
Alpha_adaptinC2 703..799 CDD:197886 28/155 (18%)
B2-adapt-app_C 809..919 CDD:198088 25/137 (18%)
Copb1NP_203534.1 Adaptin_N 18..550 CDD:366724 123/601 (20%)
HEAT 1 96..131 7/34 (21%)
HEAT 2 132..168 10/35 (29%)
HEAT repeat 137..161 CDD:293787 7/23 (30%)
HEAT repeat 173..211 CDD:293787 10/59 (17%)
HEAT repeat 221..272 CDD:293787 13/70 (19%)
HEAT 3 240..276 9/41 (22%)
HEAT 4 277..314 9/36 (25%)
HEAT repeat 280..307 CDD:293787 7/26 (27%)
HEAT 5 316..353 5/36 (14%)
HEAT repeat 318..342 CDD:293787 3/23 (13%)
HEAT 6 396..433 2/36 (6%)
Coatamer_beta_C 667..807 CDD:369484 29/159 (18%)
Coatomer_b_Cpla 813..944 CDD:373307 24/129 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5096
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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