DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and ap3b1a

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_021324676.1	Gene:	ap3b1a / 563316	ZFINID:	ZDB-GENE-031112-8	Length:	1111	Species:	Danio rerio

Alignment Length:	1114	Identity:	272/1114 - (24%)
Similarity:	460/1114 - (41%)	Gaps:	279/1114 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMN 75
            ||.|  :||..|.::|:..|.||:|:|:..:..||:.|.|||.||..:.:.|:|||||||:||:.
Zfish    50 KKNE--DLKEMLESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVR 112

  Fly    76 YAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKT 140
            ||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..||||||
Zfish   113 YAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKT 177

  Fly   141 AAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTI 205
            ||..:.|||.:.....|.  .::.::.||.|.:.:|..:.|.|..|:   ......|:..|   .
Zfish   178 AAHAIQKLYSLDPDQKEH--LIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHKN---Y 234

  Fly   206 NKLLTALNECTEWGQVFILDSLANY-------------------------SPKDEREAQS----- 240
            .||...|.:..|||||.|:..|..|                         |.::.|..||
Zfish   235 RKLCNLLVDVEEWGQVVIIHMLTRYARTQFISPWREDAIFDENSEKTFYDSEEERRVDQSKPYIM 299

  Fly   241 ------ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEV 299
                  :.....|.|...|.|||::..::...|     :.....:.:||.    ||.||.|..||
Zfish   300 DPDHRLLLRNTKPLLQSRNTAVVMAVCQLYWHL-----APKHEISIITKS----LVRLLRSHREV 355

  Fly   300 QYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYAT 364
            |||.|:||..:..:|..:.:..||.|:|:..|..::|..||:|:..|||::||:.:|.|.:.|..
Zfish   356 QYVVLQNIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVK 420

  Fly   365 EVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESI 429
            ..|..|....::||||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|:::..|
Zfish   421 SQDKAFAAATIQAIGRCATNISEVTDTCLNGLVLLLSNRDETVVAESVVVIKKLLQTQPSQHSDI 485

  Fly   430 ISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVVKLF 493
            |..:.:..|.:..|.||||::|::|||.|.:.. |.::|....:.|..|...|:||.:....||:
Zfish   486 IKHMAKLFDNITVPMARASILWLMGEYCEHVPKIAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLY 550

  Fly   494 LKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLADKP----- 547
            |.....|:.|.|::|:|...| .|.|:||| .||...::..:.:.     |:.:::|.||
Zfish   551 LTNSKQTKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNEKSGALSKYARRILMAPKPAPVLQ 614

  Fly   548 -----------------LISEETDLLE---------------------------PTL-------- 560
                             |.|:.|..||                           |:|
Zfish   615 SAFKDRDRYQLGTLSHTLNSQATGYLELSDWPAAAPDQSVRNVEVVEPVKESGAPSLGKSKAGKS 679

  Fly   561 ---------------LDELICHISSLAS---------------VYHKPPTAFVE----------- 584
                           .:|.....||.:|               |.:|..::..|
Zfish   680 KEKFYSDEEEEEEEEDEESNSEDSSSSSSEESESGSESEENSEVSNKSSSSQSEKSSSESDSDKK 744

  Fly   585 ----------------------GRGAGVRKSLPNRAAGSAAGAEQAENAAGSEA----------- 616
                                  ...||..:|.....:||.:.:.::.:.:|||:
Zfish   745 KKTQKNKKIQQQKPDSKNRKQKNGNAGKSESRSESESGSGSSSSESSSDSGSESGSELESDSDSG 809

  Fly   617 ---------------MVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAE 666
                           .|:...|.....||.:|..||    .|..|....:|
Zfish   810 TDQKKNTKSKPVQSKPVVKQVEKKEVSLLDLDDFAP----TPVTTPKSSIL-------------- 856

  Fly   667 AAPGGATSLLGDIFGL-----GGATLSVGVQIPKVTW--LPAEKGKGLEIQGTFSRR-----NGE 719
                 :.|||.|:.||     .....|..|.:|:.::  |....||||..|..|:|:     :..
Zfish   857 -----SPSLLSDLQGLSISPTSALQASSPVFVPETSYELLHRMTGKGLSGQYRFTRQPCIYDSSM 916

  Fly   720 VFMDMTLTNKAMQPMTNFAIQLNKNS------FGLVPASPMQAAPLPPNQSIEVSMALGTNGPIQ 778
            |.:.:||:|.:.||:.|..|....:|      |..|..       |.|..|:.||:.:..|...|
Zfish   917 VSLQLTLSNSSEQPLENIHISQKSSSAQNIHCFNAVER-------LEPQASVTVSIGVNFNDSTQ 974

  Fly   779 RMEPLNNLQVAVKNNIDIFYFACLVH---GNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGV 840
            ..    |.|:..|.:    .|:..:.   |.:|...  .:.:..|.....::...||...|::
Zfish   975 AA----NFQLCTKED----EFSVSIQPAVGELLLPV--SMSEADFTREQGKLLGMNESSATIT-- 1027

  Fly   841 IGTTDGIASKMTTNNIFTIAKRNV--EGQDMLYQ--SLKLTNNIWVLLELKLQPGNPEATLSLKS 901
             .:.:.|:|:..:..:.::|...|  ..|:.:::  ...::::..||:.:.|:  :|:|.:::.:
Zfish  1028 -MSPENISSQSVSRKVVSVANLGVISSTQENIHRFAGKTVSSSSLVLVSVTLK--DPDAQITVNT 1089

  Fly   902 RSVEVANII 910
            ....:.:::
Zfish  1090 EKSVMGSML 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	169/534 (32%)
		HEAT repeat	51..75	CDD:293787	14/23 (61%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	55/205 (27%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	12/31 (39%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	12/28 (43%)
		HEAT repeat	465..495	CDD:293787	8/29 (28%)
		HEAT repeat	506..542	CDD:293787	11/41 (27%)
		Alpha_adaptinC2	703..799	CDD:197886	28/106 (26%)
		B2-adapt-app_C	809..919	CDD:198088	14/106 (13%)
ap3b1a	XP_021324676.1	Adaptin_N	54..587	CDD:307641	178/550 (32%)
		HEAT repeat	124..152	CDD:293787	11/27 (41%)
		HEAT repeat	158..186	CDD:293787	10/27 (37%)
		HEAT repeat	195..221	CDD:293787	6/27 (22%)
		AP3B1_C	832..974	CDD:317233	42/171 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920