Protein Alignment AP-1-2beta and ap3b1a

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: XP_073791871.1
• Gene: ap3b1a / 563316
• ZFINID: ZDB-GENE-031112-8
• Length: 1116
• Species: Danio rerio
• Alignment Length: 1108
• Identity: 269/1108 - (24%)
• Similarity: 457/1108 - (41%)
• Gaps: 277/1108 - (25%)

  Fly    17 ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
            :||..|.::|:..|.||:|:|:..:..||:.|.|||.||..:.:.|:|||||||:||:.||:.|.
Zfish    59 DLKEMLESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQ 123

  Fly    82 DMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146
            |:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..||||||||..:.
Zfish   124 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQ 188

  Fly   147 KLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTA 211
            |||.:.....|.  .::.::.||.|.:.:|..:.|.|..|:   ......|:..|   ..||...
Zfish   189 KLYSLDPDQKEH--LIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHKN---YRKLCNL 245

  Fly   212 LNECTEWGQVFILDSLANY-------------------------SPKDEREAQS----------- 240
            |.:..|||||.|:..|..|                         |.::.|..||
Zfish   246 LVDVEEWGQVVIIHMLTRYARTQFISPWREDAIFDENSEKTFYDSEEERRVDQSKPYIMDPDHRL 310

  Fly   241 ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALR 305
            :.....|.|...|.|||::..::...|     :.....:.:||.    ||.||.|..|||||.|:
Zfish   311 LLRNTKPLLQSRNTAVVMAVCQLYWHL-----APKHEISIITKS----LVRLLRSHREVQYVVLQ 366

  Fly   306 NINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDF 370
            ||..:..:|..:.:..||.|:|:..|..::|..||:|:..|||::||:.:|.|.:.|....|..|
Zfish   367 NIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKSQDKAF 431

  Fly   371 VRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCE 435
            ....::||||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|:::..||..:.:
Zfish   432 AAATIQAIGRCATNISEVTDTCLNGLVLLLSNRDETVVAESVVVIKKLLQTQPSQHSDIIKHMAK 496

  Fly   436 NLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSD 499
            ..|.:..|.||||::|::|||.|.:.. |.::|....:.|..|...|:||.:....||:|.....
Zfish   497 LFDNITVPMARASILWLMGEYCEHVPKIAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLYLTNSKQ 561

  Fly   500 TQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLADKP----------- 547
            |:.|.|::|:|...| .|.|:||| .||...::..:.:.     |:.:::|.||
Zfish   562 TKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNEKSGALSKYARRILMAPKPAPVLQSAFKDR 625

  Fly   548 -----------LISEETDLLE---------------------------PTL-------------- 560
                       |.|:.|..||                           |:|
Zfish   626 DRYQLGTLSHTLNSQATGYLELSDWPAAAPDQSVRNVEVVEPVKESGAPSLGKSKAGKSKEKFYS 690

  Fly   561 ---------LDELICHISSLAS---------------VYHKPPTAFVE----------------- 584
                     .:|.....||.:|               |.:|..::..|
Zfish   691 DEEEEEEEEDEESNSEDSSSSSSEESESGSESEENSEVSNKSSSSQSEKSSSESDSDKKKKTQKN 755

  Fly   585 ----------------GRGAGVRKSLPNRAAGSAAGAEQAENAAGSEA----------------- 616
                            ...||..:|.....:||.:.:.::.:.:|||:
Zfish   756 KKIQQQKPDSKNRKQKNGNAGKSESRSESESGSGSSSSESSSDSGSESGSELESDSDSGTDQKKN 820

  Fly   617 ---------MVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGA 672
                     .|:...|.....||.:|..||    .|..|....:|                   :
Zfish   821 TKSKPVQSKPVVKQVEKKEVSLLDLDDFAP----TPVTTPKSSIL-------------------S 862

  Fly   673 TSLLGDIFGL-----GGATLSVGVQIPKVTW--LPAEKGKGLEIQGTFSRR-----NGEVFMDMT 725
            .|||.|:.||     .....|..|.:|:.::  |....||||..|..|:|:     :..|.:.:|
Zfish   863 PSLLSDLQGLSISPTSALQASSPVFVPETSYELLHRMTGKGLSGQYRFTRQPCIYDSSMVSLQLT 927

  Fly   726 LTNKAMQPMTNFAIQ------LNKNSFGLVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLN 784
            |:|.:.||:.|..|.      .|.:.|..|..       |.|..|:.||:.:..|...|..
Zfish   928 LSNSSEQPLENIHISQKSSCAQNIHCFNAVER-------LEPQASVTVSIGVNFNDSTQAA---- 981

  Fly   785 NLQVAVKNNIDIFYFACLVH---GNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDG 846
            |.|:..|.:    .|:..:.   |.:|...  .:.:..|.....::...||...|::   .:.:.
Zfish   982 NFQLCTKED----EFSVSIQPAVGELLLPV--SMSEADFTREQGKLLGMNESSATIT---MSPEN 1037

  Fly   847 IASKMTTNNIFTIAKRNV--EGQDMLYQ--SLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVA 907
            |:|:..:..:.::|...|  ..|:.:::  ...::::..||:.:.|:  :|:|.:::.:....:.
Zfish  1038 ISSQSVSRKVVSVANLGVISSTQENIHRFAGKTVSSSSLVLVSVTLK--DPDAQITVNTEKSVMG 1100

  Fly   908 NII 910
            :::
Zfish  1101 SML 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	169/534 (32%)
		HEAT repeat	51..75	CDD:293787	14/23 (61%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	12/31 (39%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	12/28 (43%)
		HEAT repeat	465..495	CDD:293787	8/29 (28%)
		HEAT repeat	506..542	CDD:293787	11/41 (27%)
		Alpha_adaptinC2	703..799	CDD:197886	28/106 (26%)
		B2-adapt-app_C	809..919	CDD:198088	14/106 (13%)
ap3b1a	XP_073791871.1	None