Protein Alignment AP-1-2beta and ap1b1

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: XP_005165223.1
• Gene: ap1b1 / 562166
• ZFINID: ZDB-GENE-061025-1
• Length: 992
• Species: Danio rerio
• Alignment Length: 979
• Identity: 698/979 - (71%)
• Similarity: 800/979 - (81%)
• Gaps: 62/979 - (6%)

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
Zfish    17 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 81

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
Zfish    82 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 146

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.| |....
Zfish   147 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAE-SHPNS 210

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|:::|..|||||||||||||||||:||||.||||:|:|:||:||||||:||||:|||:||||||
Zfish   211 NLLDLNPQTINKLLTALNECTEWGQIFILDCLANYTPRDDRESQSICERVTPRLSHANSAVVLSA 275

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.:|||..|.|:..||.||||||||||||:|||:||||||||||||||||:|||||||||
Zfish   276 VKVLMKFMEMLPKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 340

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
Zfish   341 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 405

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            ||||||||||||||||||||||||||||||||||||||:|:|||||||:||||||||:|:||:||
Zfish   406 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGE 470

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.|||||||||:||||||:|::||||||.||||||||||||||
Zfish   471 YAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 535

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||.||||||||:||||||||||:||||||||||||.:|||||||||:|||||
Zfish   536 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICHIGTLASVYHKPPSAFVEG 600

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAE--NAAGSEA--MVIPNQESLIGDLLSMDINAPAMPSAPAAT 646
            ......|.||.| |||...||..|  .:..|||  .|||:|..|:||||::|: |||..:.|:..
Zfish   601 SRGVQHKRLPAR-AGSGESAESPEVGQSGTSEAPPAVIPSQGDLLGDLLNLDL-APATTTVPSVQ 663

  Fly   647 SN-----VDLLGGGLDIL---------------------------------LGGPPAEAAPGGAT 673
            .:     :||||||||.|                                 :||.|:..|..||.
Zfish   664 PSMQMGAMDLLGGGLDSLMGDESDTPGVSHRTEMQSPQPSSDYSERELGGDIGGSPSMGAALGAP 728

  Fly   674 SL--------------LGDIFGLGGAT-LSVGVQI-PKVTWLPAEKGKGLEIQGTFSRRNGEVFM 722
            :.              |||:|.|||.. :..|..: ||..:|||.|.|||||.|||:||.|.:.|
Zfish   729 AAMPAALSNAPAVGGGLGDLFDLGGGVGMPTGFYVAPKTLFLPAMKAKGLEISGTFARRGGIIQM 793

  Fly   723 DMTLTNKAMQPMTNFAIQLNKNSFGLVPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNL 786
            |::||||||..||:||||.|:|||||.||.|:|. .||.|||:|:||:.|||.||:.:|||||||
Zfish   794 DLSLTNKAMSVMTDFAIQFNRNSFGLAPAGPLQVLTPLTPNQTIDVSLPLGTTGPVMKMEPLNNL 858

  Fly   787 QVAVKNNIDIFYFACLVHGNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKM 851
            |||||||||:|||:|....::||.|||:::::|||.|||:||..||.|:.:..|...:|..::|:
Zfish   859 QVAVKNNIDVFYFSCQYPLSLLFVEDGKMERQVFLATWKDIPNDNEAQFQIKDVHLNSDAASNKL 923

  Fly   852 TTNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEA 916
            ..:||||||||.|:.|||||||:||||.||||.|:::|.|||..|||:|.|:.||:..::..||.
Zfish   924 QGSNIFTIAKRTVDAQDMLYQSIKLTNGIWVLAEMRVQTGNPNYTLSIKCRAPEVSQFVYQCYEL 988

  Fly   917 IIRS 920
            ::::
Zfish   989 VLKN 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	436/496 (88%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..229	CDD:293787	24/31 (77%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	24/29 (83%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	66/96 (69%)
		B2-adapt-app_C	809..919	CDD:198088	56/109 (51%)
ap1b1	XP_005165223.1	Adaptin_N	27..550	CDD:396262	461/523 (88%)
		HEAT repeat	67..91	CDD:293787	23/23 (100%)
		HEAT repeat	103..130	CDD:293787	25/26 (96%)
		HEAT repeat	137..167	CDD:293787	28/29 (97%)
		HEAT repeat	176..202	CDD:293787	23/25 (92%)
		HEAT repeat	213..244	CDD:293787	23/30 (77%)
		HEAT repeat	371..395	CDD:293787	22/23 (96%)
		HEAT repeat	407..435	CDD:293787	27/27 (100%)
		HEAT repeat	443..474	CDD:293787	24/30 (80%)
		HEAT repeat	480..506	CDD:293787	20/25 (80%)
		Alpha_adaptinC2	772..872	CDD:197886	68/99 (69%)
		B2-adapt-app_C	881..991	CDD:198088	56/109 (51%)