DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and ap4b1

DIOPT Version :10

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_956632.1 Gene:ap4b1 / 393309 ZFINID:ZDB-GENE-040426-1284 Length:729 Species:Danio rerio


Alignment Length:645 Identity:193/645 - (29%)
Similarity:335/645 - (51%) Gaps:65/645 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 YFTTTKKGEIFELKSELNNDKKE----KKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELK 66
            ||.:.:  .:.|||..|:|...:    :.|..:.|||..||.|.||||||.|:|....|.::..|
Zfish     3 YFGSEE--TVKELKRALSNPNVQADRLRYKSYITKVIRYMTQGLDVSALFMDMVKASATVDIVQK 65

  Fly    67 KLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
            ||||||:..||..:||:|::|:||..|||.|.||::|.||:|.|...|:..:|||:.:|:...|:
Zfish    66 KLVYLYMCTYASDKPDLALLAINTLRKDCADPNPMVRGLALRNMCNFRMPGMTEYIEQPIVAGLR 130

  Fly   132 DEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQP 196
            |:..|||:.|.:..||::.:......|...:::|..||.|.:|:||.|.:.||.:|         
Zfish   131 DKASYVRRVAVLGCAKMHSLQPRTEIDGSLVNELYALLRDPDPVVVVNCLRALEDI--------- 186

  Fly   197 LVEMNSVTINK-----LLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAV 256
            |.:...|.|||     ||..|.:...|.|..:|..|..|.|:::.|...|...:.|.|..:.:.|
Zfish   187 LKDEGGVVINKPIAHHLLNRLKDLDCWAQSEVLTFLLRYRPRNDDELFDILSLLDPFLQSSQSHV 251

  Fly   257 VLSAVKVLMKLL---EMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDIL 318
            .:|.:::.:.|.   ..:.:|:..|::     ||.|.|..::..|:::..|.:|..:::.:|.:.
Zfish   252 AISTLRLFLHLAAAHPAVQADALLCSS-----APLLATCGAASRELRFAGLCHIQQVMRSQPALF 311

  Fly   319 KHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAI 383
            ....|.||..|::|.|:|..|::|::.|.|..|:|.||.|:|.|.|:|..:..:.|:.||||.. 
Zfish   312 NTHYKRFFCGYSEPSYIKFRKMEILVALVNDENVALVLEEMKSYCTDVSAELAQAAIAAIGRIG- 375

  Fly   384 KVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARAS 448
              ...:|:|:..|..|:..|.:::....|...:|:....|....::..|:...:|...:.|.:.:
Zfish   376 --RTYSEKCLDILTGLLALKQDHITSAVIQTFRDLVWFCPQCTAAVCLTVESCVDYPQDSEGKQA 438

  Fly   449 MVWIIGEYAERIDNADELLDSFLEGFQDE-NAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLAT 512
            ::|::||:|::|.:|..||:.:::|.:.| :|.:::::|||.:|:||:||::||:::..:|....
Zfish   439 LLWLLGEHADQISSAPYLLEVYIDGLKTELSAALKMEILTAALKMFLRRPAETQDMLGRLLHYCI 503

  Fly   513 QDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADK--PLISEET--------------DLLEPTLL 561
            ::..:..:|||..:|:|||.......::||...|  |.:|..|              :.|.|...
Zfish   504 EEESDMCVRDRALLYYRLLQRGIEETRKVVTGPKSDPSLSVLTSAQEEPVSQWVSIFNTLGPLSA 568

  Fly   562 DELICHISSLASVYHKPPTAFVE------------GRGAGVRKSLPNRAAGSAAGAEQAE 609
            .:|..|.::|::..|...||..|            ...|||     :..||:|...|..|
Zfish   569 ADLQLHNTALSASEHTDDTADTELLTEHVPVSMRDVSEAGV-----SLCAGAAVSPEAFE 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 160/505 (32%)
HEAT repeat 51..75 CDD:293787 11/23 (48%)
HEAT repeat 87..114 CDD:293787 14/26 (54%)
HEAT repeat 121..151 CDD:293787 10/29 (34%)
HEAT repeat 160..186 CDD:293787 10/25 (40%)
HEAT repeat 197..229 CDD:293787 12/36 (33%)
HEAT repeat 393..417 CDD:293787 4/23 (17%)
HEAT repeat 429..458 CDD:293787 6/28 (21%)
HEAT repeat 465..495 CDD:293787 10/30 (33%)
HEAT repeat 506..542 CDD:293787 8/35 (23%)
Alpha_adaptinC2 703..799 CDD:197886
B2-adapt-app_C 809..919 CDD:198088
ap4b1NP_956632.1 Adaptin_N 11..525 CDD:396262 168/530 (32%)
HEAT repeat 86..113 CDD:293787 14/26 (54%)
HEAT repeat 120..150 CDD:293787 10/29 (34%)
HEAT repeat 159..185 CDD:293787 10/25 (40%)
HEAT repeat 196..222 CDD:293787 8/25 (32%)
HEAT repeat 233..257 CDD:293787 5/23 (22%)
B2-adapt-app_C 614..719 CDD:462667 4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

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