DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and copb1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001002013.1	Gene:	copb1 / 338138	ZFINID:	ZDB-GENE-030219-38	Length:	953	Species:	Danio rerio

Alignment Length:	1045	Identity:	198/1045 - (18%)
Similarity:	360/1045 - (34%)	Gaps:	314/1045 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNYAKSQP 81
            ||::|...:.:.|.||:||||..:..|:.:..|...::. .:...:..:|||:.::.....|:.|
Zfish    26 LKTDLEKGEIKAKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTP 90

  Fly    82 D-----MAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTA 141
            |     ..|:..:.:.||.:..|..||...:|.:..::..::.|.|...:|.||:....|||:.|
Zfish    91 DGKLLQEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKESELLEPLMPAIRACLERRHSYVRRNA 155

  Fly   142 AVCVAKLYDISATMVED-----QGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMN 201
            .:.:..:|.....::.|     ..||...||.....|         |...:..|.|..
Zfish   156 VLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRN---------AFMMLIHADQDR------- 204

  Fly   202 SVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMK 266
              .::.|.|.:::...:|.:.                |.:...:..::.|||.:.....::.:..
Zfish   205 --ALDYLSTCIDQVHTFGDIL----------------QLVIVELIYKVCHANPSERARFIRCIYN 251

  Fly   267 LLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQ-----YVAL------RNINLIVQKRPDILK- 319
            ||:..|      ..:..:.|..||||.|:...::     |:.|      .|:.|||..|...||
Zfish   252 LLQSSS------PAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKE 310

  Fly   320 ---HE-------MKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEV-------D 367
               ||       |.:..|.....:.|:.:.|.:.:.|.:..|:.:::..||:...:.       |
Zfish   311 HPTHERVLQDLVMDILRVLTTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVTEHED 375

  Fly   368 VDFVRK-AVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIIS 431
            .|..|: .||.:..|:::....|...:..|::.:.........:.:..:::..:::.|....||.
Zfish   376 TDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDTNEAAAADVLEFVREAIQRFDNLRPLIIE 440

  Fly   432 TLCENLDTLDEPEARASMVWIIGEYAERIDNADELLDSFLEGFQDENAQVQLQL-LTAVVKLFLK 495
            .:.|....:...:.....:||:|||.           |..|..|....:|:..| ...:|:..||
Zfish   441 KMLEVFHAIKTVKIYRGALWILGEYC-----------STKEDIQSVMTEVRRSLGEIPIVENELK 494

  Fly   496 ------RPSD------TQELVQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADKPL 548
                  :|.:      ..:||..:.:..||.:               |||...:.||
Zfish   495 KEAGEVKPEEEVTAAPAPKLVTEMGTYVTQSA---------------LSTSRPSKKE-------- 536

  Fly   549 ISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRKSLPNRAAGSAAGAEQAENAAG 613
              |:...|...|:|......:|||:...|....:|                 :.|..::.:|:..
Zfish   537 --EDRPPLRGFLMDGDFYVAASLATTLTKVALRYV-----------------ALAEDKRRQNSFV 582

  Fly   614 SEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLLGD 678
            :|||:|.        ...:.:...::|..|....:||.:...|.:|     :|.:|     |:.|
Zfish   583 AEAMLIM--------ATVLHLGKSSLPKKPITDDDVDRISLCLKVL-----SECSP-----LMND 629

  Fly   679 IFGLG-----GATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNF- 737
            ||...     ...|:|.::..|::.....:.:.:.:|..    :...||.:|..|:.......|
Zfish   630 IFNKECRRSLSHMLAVRLEEEKLSQKKESEKRNVTVQAD----DPISFMQLTAKNEMASKEDQFQ 690

  Fly   738 -------------------AIQLNK-------------------NSFGLVPASPMQAAPLPPNQS 764
                               |.:|||                   |.:.:|      ...|..||:
Zfish   691 LSLLAAMGNTQRKEATDPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV------LDVLVVNQT 749

  Fly   765 IEV----SMALGTNGPIQRME---PLN-----------NLQVAVKNNIDIFYFACLVHGNVLFAE 811
            .:.    ::.|.|.|.::.:|   ||.           |::||...|..||       ||:::..
Zfish   750 SDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIF-------GNIVYDV 807

  Fly   812 DGQLDKR------------------------VFLNTWKEIPAANELQYTLSGVIGTTDGIASKMT 852
            .|....|                        .|...|.|....|                  |:|
Zfish   808 SGAASDRNCVVLSDIHIDIMDYIQPASCTDAEFRQMWAEFEWEN------------------KVT 854

  Fly   853 TNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLS---------LKSRSV---- 904
            .|...|      :..|.|...||.||         ::...||..||         |.:||:
Zfish   855 VNTNIT------DLNDYLLHILKSTN---------MKCLTPEKALSGICGFMAANLYARSIFGED 904

  Fly   905 EVANI 909
            .:||:
Zfish   905 ALANV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	103/550 (19%)
		HEAT repeat	51..75	CDD:293787	3/24 (13%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		Cnd1	99..269	CDD:289487	31/174 (18%)
		HEAT repeat	121..151	CDD:293787	9/29 (31%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	3/31 (10%)
		HEAT repeat	393..417	CDD:293787	1/23 (4%)
		HEAT repeat	429..458	CDD:293787	8/28 (29%)
		HEAT repeat	465..495	CDD:293787	6/30 (20%)
		HEAT repeat	506..542	CDD:293787	7/35 (20%)
		Alpha_adaptinC2	703..799	CDD:197886	27/152 (18%)
		B2-adapt-app_C	809..919	CDD:198088	25/138 (18%)
copb1	NP_001002013.1	Adaptin_N	26..550	CDD:279882	118/599 (20%)
		HEAT 1. /evidence=ECO:0000255	96..131		7/34 (21%)
		HEAT 2. /evidence=ECO:0000255	132..168		10/35 (29%)
		HEAT repeat	137..161	CDD:293787	7/23 (30%)
		HEAT repeat	173..211	CDD:293787	9/55 (16%)
		HEAT repeat	221..272	CDD:293787	11/72 (15%)
		HEAT 3. /evidence=ECO:0000255	240..276		9/41 (22%)
		HEAT 4. /evidence=ECO:0000255	277..314		9/36 (25%)
		HEAT repeat	280..307	CDD:293787	7/26 (27%)
		HEAT 5. /evidence=ECO:0000255	316..353		5/36 (14%)
		HEAT repeat	318..342	CDD:293787	3/23 (13%)
		HEAT 6. /evidence=ECO:0000255	396..433		2/36 (6%)
		Coatamer_beta_C	667..807	CDD:285019	28/156 (18%)
		Coatomer_b_Cpla	816..944	CDD:291472	23/127 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810