DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and ap2b1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_956213.2	Gene:	ap2b1 / 334632	ZFINID:	ZDB-GENE-030131-6564	Length:	951	Species:	Danio rerio

Alignment Length:	962	Identity:	689/962 - (71%)
Similarity:	789/962 - (82%)	Gaps:	53/962 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||.|||||||||:||||:||||:|||||||||:||||||||:||||||||||||||||
Zfish     1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||:|||||||.||||||||||||||||||||||||||||||||
Zfish    66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.|||||||||.|:||::|||||||||||||||||:| |....
Zfish   131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISE-SHPNS 194

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|:::|...||||||||||||||||:||||.|:||:|||||||||||||:||||:|||:||||||
Zfish   195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDEREAQSICERVTPRLSHANSAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.||:|..|||:..||.|||:||||||||.||||||||||||||||||||:|||.|:|||
Zfish   260 VKVLMKFLELLPKDSDYYNTLLKKLSPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:.:||||||:|||||||||||||||||||||||||||||.|||
Zfish   325 FVKYNDPIYVKLEKLDIMIRLASHANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            |||||||||||||||||||||||||:||||||||||||||:|||||||:||||:||.:|:||:||
Zfish   390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.||||.||||:||||||:||:||||||.||||||||||||||
Zfish   455 YAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||..||||||::||||||||||:||||||||||||.||||||||||.|||||
Zfish   520 RDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLPNR-----------AAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMD----IN 635
            .....||.||.:           :.|.||..:|.:        |||:|..|:||||::|    :|
Zfish   585 SHGIHRKHLPIQHGSIDTGESPVSTGPAASIDQPQ--------VIPSQGDLLGDLLNLDLGPPVN 641

  Fly   636 APAMPSAPAATSNVDLLGGGLDILL--------GGPPA----------------EAAPGGATSLL 676
            .|.:.|...|.  |||||||||.||        ||.||                ...|...:|.|
Zfish   642 VPQVSSMQIAA--VDLLGGGLDSLLGGDLGGGVGGSPAVGQNFIPSSVPNTFAPSPTPAALSSGL 704

  Fly   677 GDIFGL--GGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAI 739
            .|:|.|  |.||.:.|....|..||||.|.|||||.||||||.|.::||||.||||:|.||:|||
Zfish   705 NDLFELSTGMATATGGYVAAKTVWLPAVKAKGLEISGTFSRRQGHMYMDMTFTNKALQHMTDFAI 769

  Fly   740 QLNKNSFGLVPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLV 803
            |.||||||::|.:|:.. .||.|:|||::|:.|.|.||:.:|:||||||||||||||:|||:.|:
Zfish   770 QFNKNSFGVIPTTPLPVHTPLMPSQSIDISLPLNTIGPVMKMDPLNNLQVAVKNNIDVFYFSTLI 834

  Fly   804 HGNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQD 868
            ..||.|.|||:::::|||.|||:||..|||||.:.......|.::.|:.:||::|||||||||||
Zfish   835 PLNVFFVEDGKMERQVFLATWKDIPNENELQYQIKDCHLNADTVSGKLQSNNVYTIAKRNVEGQD 899

  Fly   869 MLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920
            ||||||||||.||:|.||::|||||..|||||.|:.||:..::..|:|.:::
Zfish   900 MLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYVYQMYDATLKN 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	429/496 (86%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		Cnd1	99..269	CDD:289487	141/169 (83%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	21/28 (75%)
		HEAT repeat	465..495	CDD:293787	23/29 (79%)
		HEAT repeat	506..542	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	703..799	CDD:197886	63/96 (66%)
		B2-adapt-app_C	809..919	CDD:198088	62/109 (57%)
ap2b1	NP_956213.2	Adaptin_N	11..534	CDD:279882	453/523 (87%)
		HEAT repeat	15..42	CDD:293787	22/26 (85%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		Cnd1	99..268	CDD:289487	141/169 (83%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	392..416	CDD:293787	23/23 (100%)
		HEAT repeat	428..457	CDD:293787	21/28 (75%)
		HEAT repeat	464..494	CDD:293787	23/29 (79%)
		HEAT repeat	505..541	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	731..831	CDD:197886	65/99 (66%)
		B2-adapt-app_C	840..950	CDD:198088	62/109 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	897	1.000	Domainoid score	I49
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1331	1.000	Inparanoid score	I141
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm26386
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	O	PTHR11134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980