DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and Ap4b1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001101179.1	Gene:	Ap4b1 / 310746	RGDID:	1310529	Length:	739	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	189/641 - (29%)
Similarity:	334/641 - (52%)	Gaps:	65/641 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELKSELNND----KKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYA 77
            |||..|.|.    .:.:.:..:::||..||.|.|:|.:|.::|....|.::..|||||||:..||
  Rat    12 ELKKALCNPHIQADRLRYRNVIQRVIRHMTQGLDMSDVFMEMVKASATVDIVQKKLVYLYMGTYA 76

  Fly    78 KSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAA 142
            ..:||:|::|:||..|||.|.||::|.||:|:|..:|:..:.||:.:|:...|:|:..|||:.|.
  Rat    77 PLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPVVNGLRDKASYVRRVAV 141

  Fly   143 VCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINK 207
            :..||::::......|...:::|..||.|.:|:||.|.:.:|.||         |.:...|.|||
  Rat   142 LGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEI---------LKQEGGVVINK 197

  Fly   208 -----LLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVK---VL 264
                 ||..:::..:|||..:|:.|..|.|:.|.|...|...:...|..::..||:.|.|   :|
  Rat   198 PIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSYLKSSSTGVVMGATKLFLIL 262

  Fly   265 MKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEP-EVQYVALRNINLIVQKRPDILKHEMKVFFVK 328
            .|....:.:|      :..::..||:...|||. |:.:.||.::..::...|.......|.||..
  Rat   263 AKKFPHVQTD------VLVRVKGPLLAACSSESRELCFAALCHVRQVLHSLPGHFSSHYKKFFCS 321

  Fly   329 YNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCV 393
            |::|.|:||:|::::..|.|..|:.|||.||:.|.|:|..||.:.|:.|||..|   :...::||
  Rat   322 YSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGNIA---KTYTDQCV 383

  Fly   394 STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTL--CENLDTLDEPEARASMVWIIGEY 456
            ..|.:|:..:..::....:...:|:....|...|::...|  ||  :.:.:.|.:.:::|::|.:
  Rat   384 QILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCE--ENIQDSEGKQALIWLLGVH 446

  Fly   457 AERIDNADELLDSFLEGFQDEN-AQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            .|:|.||..:|:.|:|..:.|. ..|:::||||:::|||.||::.|:::..:|....::..:..:
  Rat   447 GEKIPNAPYVLEDFVESVKSETFPAVKMELLTALMRLFLSRPAECQDVLGRLLLYCIEEEKDMAV 511

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTL----------LDELICHISSLASVY 575
            ||||..|:|||.......|:::.:.|.         :|:|          ::......::||.||
  Rat   512 RDRGLFYYRLLLVGIDKTKQILCSPKS---------DPSLGLLEDQPERPVNSWASDFNTLAPVY 567

  Fly   576 HKPPTAFVE--GRGAGVRKSLPNRAAGSAAG-------AEQAENAAGSEAMV-IPN 621
            .|...|.:.  .:....|..||:.|:.:.:|       .|.|:....|.|:| :||
  Rat   568 GKAHWATISKCQKIEPHRLELPHNASFATSGHLIAEENKEGAQEPPDSGALVLVPN 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	161/508 (32%)
		HEAT repeat	51..75	CDD:293787	10/23 (43%)
		HEAT repeat	87..114	CDD:293787	14/26 (54%)
		Cnd1	99..269	CDD:289487	55/177 (31%)
		HEAT repeat	121..151	CDD:293787	10/29 (34%)
		HEAT repeat	160..186	CDD:293787	9/25 (36%)
		HEAT repeat	197..229	CDD:293787	12/36 (33%)
		HEAT repeat	393..417	CDD:293787	3/23 (13%)
		HEAT repeat	429..458	CDD:293787	6/30 (20%)
		HEAT repeat	465..495	CDD:293787	11/30 (37%)
		HEAT repeat	506..542	CDD:293787	10/35 (29%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
Ap4b1	NP_001101179.1	Adaptin_N	9..525	CDD:279882	167/532 (31%)
		HEAT repeat	86..113	CDD:293787	14/26 (54%)
		Cnd1	98..235	CDD:289487	47/145 (32%)
		HEAT repeat	120..150	CDD:293787	10/29 (34%)
		HEAT repeat	159..185	CDD:293787	9/25 (36%)
		HEAT repeat	198..222	CDD:293787	6/23 (26%)
		B2-adapt-app_C	620..732	CDD:198088	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820