DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and Ap3b1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001101116.1	Gene:	Ap3b1 / 309969	RGDID:	1310256	Length:	794	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	184/799 - (23%)
Similarity:	313/799 - (39%)	Gaps:	191/799 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 LAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQ 349
            ::..||.||.|..||||:.|:||..:..:|..:.:..:|.|:|:..||..:|..||:|:..|||:
  Rat    19 ISKSLVRLLRSHREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANE 83

  Fly   350 SNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVV 414
            :||:.:|.|.:.|....|..|....::.|||||..:....:.|::.|:.|:..:...||.|::||
  Rat    84 ANISTLLREFQTYVRSQDKQFAAATIQTIGRCATSIAEVTDTCLNGLVCLLSNRDEIVVAESVVV 148

  Fly   415 IKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDEN 478
            ||.:.:..|.::..||..:.:.||::..|.||||::|:|||..||:.. |.::|....:.|..|:
  Rat   149 IKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSED 213

  Fly   479 AQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA----- 537
            ..|:||:|....||:|.....|:.|.|::|:|...| .|.|:||| .||...::..:.:.
  Rat   214 DLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNEKSGALSKY 277

  Fly   538 AKEVVLADKPLISEETDLLEPTLLDELICHISSL-------ASVY-------------------- 575
            ||::.||.||     ..|||....|.....:.:|       ||.|
  Rat   278 AKKIFLAQKP-----APLLESPFKDRDHFQLGTLSHTLNVKASGYLELSNWPEVAPDPSVRNVEV 337

  Fly   576 ---------------HKPPTAFV-------------------------------EGRGAGVRKSL 594
                           .||...|.                               .||.:|...|.
  Rat   338 IESAKEWTPLGKTKKEKPEKKFYSESEEEEEEEEEDEEDEEEDPSDSSSDSESGSGRESGDSGSS 402

  Fly   595 PNRAA-----------GSAAGAE---------QAENAAGSEAMVIPNQESLIGDLLSMDINAPAM 639
            ...::           ||.|.||         :.:..:.||.....|.:|...:..|.:.::...
  Rat   403 SEDSSEDSSSGQDSETGSEAEAEHQRVAKTNSKTKRKSASEDREKKNGKSQASESSSEESSSTEE 467

  Fly   640 PS-----------APAATSNV--------------DLLGGGLDIL--LGGPPAEAAPGGATSLLG 677
            .|           ||..|:..              |:....||..  :..|.|...|..:.||:.
  Rat   468 SSSESESGSDSEPAPRKTAKAKERKPQQERHPPSKDVFLLDLDDFNPVSTPVALPTPALSPSLIA 532

  Fly   678 DIFGLGGATLSVGVQIPKVTWLPAE--------KGKGLEIQGTFSRR-----NGEVFMDMTLTNK 729
            |:.||..:|.|..:.:....::|.:        :||||.....|.|:     :..|.:.:||||.
  Rat   533 DLEGLNLSTSSSIINVSTPVFVPTKTHELLHRMRGKGLAAHYCFPRQPCIFGDKMVSVQITLTNT 597

  Fly   730 AMQPMTNFAIQLNKNSFG--LVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKN 792
            :...:.|..:...|.:.|  :....|:::  |.|..|:.|||.:......|..    :.|:..|:
  Rat   598 SDGKIENIHVGGKKLAVGVQMHVFHPIES--LEPEGSVTVSMGIDFCDSTQTA----SFQLCTKD 656

  Fly   793 NIDIFYFACLVHGNV-LFAEDGQL------DKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASK 850
              |.|        || :....|:|      .::.|......:...||...||   |.........
  Rat   657 --DCF--------NVNIQPPVGELLLPVAMSEKDFKKEQGMLTGMNETSATL---IAAPQNFTPS 708

  Fly   851 MTTNNIFTIAKRNV--EGQDML--YQSLK------------LTNNIWVLLELKLQPGNPEATLSL 899
            |....:..:|....  ..||.:  |:.||            :.:...:|:.::|:.|: .|.|.:
  Rat   709 MILQKVVNVANLGAVPSSQDNIHRYERLKFQVLQERFAAKTVHSGSLMLVTVELKEGS-TAQLII 772

  Fly   900 KSRSVEVANIIFAAYEAII 918
            .:....:.:::....:.::
  Rat   773 NTEKTVIGSVLLRELKPVL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	87/251 (35%)
		HEAT repeat	51..75	CDD:293787
		HEAT repeat	87..114	CDD:293787
		Cnd1	99..269	CDD:289487
		HEAT repeat	121..151	CDD:293787
		HEAT repeat	160..186	CDD:293787
		HEAT repeat	197..229	CDD:293787
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	13/28 (46%)
		HEAT repeat	465..495	CDD:293787	9/29 (31%)
		HEAT repeat	506..542	CDD:293787	12/41 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	26/102 (25%)
		B2-adapt-app_C	809..919	CDD:198088	20/132 (15%)
Ap3b1	NP_001101116.1	Adaptin_N	<1..269	CDD:279882	87/250 (35%)
		SEEEED	<413..>454	CDD:291463	9/40 (23%)
		AP3B1_C	502..646	CDD:291462	35/145 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820