DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and Ap3b2

DIOPT Version :9

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_001101002.2 Gene:Ap3b2 / 308777 RGDID:1308950 Length:1082 Species:Rattus norvegicus


Alignment Length:1102 Identity:271/1102 - (24%)
Similarity:449/1102 - (40%) Gaps:242/1102 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DSKYFTTTKKGEIF--------ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQ 59
            :.:|......|.||        :||..|:.:|...|.||:|:::|.:..||:.|.|||.||..:.
  Rat    19 EPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA 83

  Fly    60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCE 124
            ..|:|:|||||:||:.||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:..
  Rat    84 CKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMML 148

  Fly   125 PLRKCLKDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINE 189
            .:::...|..||||||||..:.|||.:.:.. :|| .::.::.||:|...:|..:.|.|..|:..
  Rat   149 AIKEAASDMSPYVRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCP 211

  Fly   190 ASQSGQPLVEMNSVTINKLLTALNECTEWGQVFILDSLANY------------------------ 230
            ..      :::......||...|.:..|||||.|:..|..|                        
  Rat   212 ER------IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENPEKAFY 270

  Fly   231 -SPKDEREAQSICERIT-----------------------PRLAHANAAVVLSAVKVLMKLLEML 271
             |.:||.:.....|..|                       |.|...:||||::..::...|....
  Rat   271 GSEEDEAKGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKA 335

  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVK 336
            .         ...:|..||.||.|..|||||.|:|:..:..||..:.:..:|.|:::..||..:|
  Rat   336 E---------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIK 391

  Fly   337 LEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQ 401
            :.||:::..|||::||..||.|.:.|...:|.|||...::||||||..:....:.|::.|:.|:.
  Rat   392 ILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLS 456

  Fly   402 TKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADE 465
            .:...||.|::||||.:.:..|.::..||..|.:..|.:..|.||||::|:||||.|.:.. |.:
  Rat   457 NRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPKIAPD 521

  Fly   466 LLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIYWRL 530
            :|....:.|..|...|:||::....||:|.....|:.|.|:|||||..| .|.|:|||.....:|
  Rat   522 VLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QNYDIRDRARFTRQL 585

  Fly   531 LSTDPAA------AKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVE----- 584
            ::.....      ||::.||.||     ..:||.:..|.....:.||:.:.:...|.:.|     
  Rat   586 IAPSEQGGALSRHAKKLFLAPKP-----APILESSFKDRDHFQLGSLSHLLNAKATGYQELPDWP 645

  Fly   585 ----------------------------------------------------------------- 584
                                                                             
  Rat   646 EEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSEPESESESGSKSSSESG 710

  Fly   585 -----------------GRGA--------GVRKSLPNRAAGS------AAGAEQAENAAGSEAMV 618
                             |.|:        |.:|....:...|      ::..|.:::::.||:.|
  Rat   711 SGESSSESDNEDDDEEKGEGSESEQSEEEGEKKKKTKKKKASEGHREGSSSEEGSDSSSSSESEV 775

  Fly   619 IPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLG------GPPAEAAPGGATSLLG 677
            ....|....:..|.....|....:..|...:.||  .|:....      .||...    :|||..
  Rat   776 TSESEEEQVEPASWRKKTPPSSKSTPAAKEISLL--DLEDFTSPSVQPVSPPMVV----STSLAA 834

  Fly   678 DIFGLGGATLSVGVQIPKV----------TWLPAEKGKGLEIQGTFSRR--NGE---VFMDMTLT 727
            |:.||   ||:....:|.:          ..|....|:||.:...|||:  :|:   |.:.:..:
  Rat   835 DLEGL---TLTDSSLVPSLLSPVSSIGRQELLHRVAGEGLAVDYAFSRQPFSGDPHMVSLHIYFS 896

  Fly   728 NKAMQPMTNFAIQLNKNSFGLVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKN 792
            |.:..|:....:...|...|:......:...|.|.:|....|.:......|..    |.|:..:.
  Rat   897 NNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQAA----NFQLCTQT 957

  Fly   793 NIDIFYFACLVHGNVLFAEDGQLDKRVFL--NTWK----EIPAANEL--QYTLSGVIGTTDGIAS 849
            .  .||.:       :....|:|...||:  |.:|    ::...||:  :.||.....:...:..
  Rat   958 R--QFYVS-------IQPPVGELMAPVFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVVQ 1013

  Fly   850 KMT-TNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANII 910
            |:| |.|:..:...  ...:..:....||:...|||.|..: |...|.|::.|..:.:..::
  Rat  1014 KVTATANLGRVPCG--ASDEYRFAGRTLTSGSLVLLTLDAR-GTGAAQLTVNSEKMVIGTML 1072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 173/545 (32%)
HEAT repeat 51..75 CDD:293787 13/23 (57%)
HEAT repeat 87..114 CDD:293787 10/26 (38%)
Cnd1 99..269 CDD:289487 55/217 (25%)
HEAT repeat 121..151 CDD:293787 12/29 (41%)
HEAT repeat 160..186 CDD:293787 6/25 (24%)
HEAT repeat 197..229 CDD:293787 10/31 (32%)
HEAT repeat 393..417 CDD:293787 8/23 (35%)
HEAT repeat 429..458 CDD:293787 14/28 (50%)
HEAT repeat 465..495 CDD:293787 8/29 (28%)
HEAT repeat 506..542 CDD:293787 14/41 (34%)
Alpha_adaptinC2 703..799 CDD:197886 20/100 (20%)
B2-adapt-app_C 809..919 CDD:198088 24/111 (22%)
Ap3b2NP_001101002.2 Adaptin_N 34..590 CDD:366724 181/573 (32%)
HEAT repeat 111..139 CDD:293787 11/27 (41%)
HEAT repeat 145..173 CDD:293787 10/27 (37%)
HEAT repeat 182..208 CDD:293787 7/26 (27%)
AP3B1_C 804..947 CDD:373301 31/151 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323029at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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