DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and apl6

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_593796.1	Gene:	apl6 / 2541771	PomBaseID:	SPAC23H3.06	Length:	745	Species:	Schizosaccharomyces pombe

Alignment Length:	668	Identity:	188/668 - (28%)
Similarity:	318/668 - (47%)	Gaps:	99/668 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIM 86
            ||::....|.||:..::|.|..|:::|..|||||..:.::|.|:::||::||:.||:..||:|::
pombe    42 LNSNSDAGKLEAINFILAQMMHGENMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALL 106

  Fly    87 AVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDI 151
            :|||..|...|.|||.|:.|:|.|..|||..|...:...:::|:.|....||::||:.:.|.|.:
pombe   107 SVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSL 171

  Fly   152 SATMVEDQGFLDQL----KDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTAL 212
                  |..:..||    |.||||::|:||..|:.....:....      :|:.....:::.|..
pombe   172 ------DPSYKSQLEEHIKTLLSDNSPIVVPAALFTFEVVCPEK------LEIIHPYYHRICTLF 224

  Fly   213 NECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDF 277
            .:..:|.:|..|.:|..|:      ..::.|..||. .|::...:|.::|..  ...:|.|....
pombe   225 PQMNDWDKVVALKTLVRYA------RLTLPEPSTPS-THSDLKELLESIKSC--FFSLLPSTIIA 280

  Fly   278 CATLTKKLAP---------PLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPI 333
            .|.....|||         ||:.||..:|.|:...||.|:.||.|.|::.|:.:|.||:..:|..
pombe   281 GARAFYYLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSD 345

  Fly   334 YVKLEKLDIMIRLANQSNIAQVLSELKEYA-TEVDVDFVRKAVRAIGRCA---IKVEPSAERCVS 394
            ...|.|::|:.||.:..|.:|:|.||..|. :..:......||:|:|..|   |.:.||   |::
pombe   346 DTCLLKINILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPS---CLN 407

  Fly   395 TLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAER 459
            |||.|:::..:.:|.||...::.:....|.  |..:..|....:||:.|.|::..:|:|.|:...
pombe   408 TLLLLLKSHNSLIVTEAASSLRLLIHNDPK--EIYLQYLAATYETLEVPRAKSVTLWLISEHILI 470

  Fly   460 IDN-ADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQE------------LVQHVLSLA 511
            |.. ..::|...::.|.||..:|:.|:|...|:|::...|:.::            |..:||||.
pombe   471 IPRLVPDVLRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLI 535

  Fly   512 TQDSDNPDLRDRGFIYWRLLSTDPAA--AKEVVLADKP-------------------LISEETDL 555
            ..|. :.|||||...|..|.|| |::  .:.:||..|.                   .::|:...
pombe   536 HFDM-SYDLRDRARFYKELAST-PSSEFTRRIVLESKGNSQKEIIASRDYCIGTASLCLNEDVMG 598

  Fly   556 LEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRKSLP-NRAAGSAAGAEQAENAAGSEAMVI 619
            .||         |.:.|.|...||.:..|    |::..|| |...|:.    .:.|:.|.:|:..
pombe   599 YEP---------IPNWADVSDLPPDSVRE----GIKDVLPINPHTGNI----YSNNSPGVKALSS 646

  Fly   620 PNQESLIGDLLSMDINAP 637
            .|.:...||  :..||.|
pombe   647 DNFKRDFGD--TNAINRP 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	156/526 (30%)
		HEAT repeat	51..75	CDD:293787	11/23 (48%)
		HEAT repeat	87..114	CDD:293787	12/26 (46%)
		Cnd1	99..269	CDD:289487	44/173 (25%)
		HEAT repeat	121..151	CDD:293787	8/29 (28%)
		HEAT repeat	160..186	CDD:293787	11/29 (38%)
		HEAT repeat	197..229	CDD:293787	6/31 (19%)
		HEAT repeat	393..417	CDD:293787	7/23 (30%)
		HEAT repeat	429..458	CDD:293787	8/28 (29%)
		HEAT repeat	465..495	CDD:293787	9/29 (31%)
		HEAT repeat	506..542	CDD:293787	15/37 (41%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
apl6	NP_593796.1	COG5096	1..745	CDD:227427	188/668 (28%)
		HEAT repeat	71..95	CDD:293787	11/23 (48%)
		HEAT repeat	107..135	CDD:293787	13/27 (48%)
		HEAT repeat	141..170	CDD:293787	7/28 (25%)
		HEAT repeat	178..204	CDD:293787	11/25 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810