Protein Alignment AP-1-2beta and apl2

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_595274.1
• Gene: apl2 / 2541255
• PomBaseID: SPBC947.02
• Length: 683
• Species: Schizosaccharomyces pombe
• Alignment Length: 694
• Identity: 314/694 - (45%)
• Similarity: 447/694 - (64%)
• Gaps: 33/694 - (4%)

  Fly     4 SKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKL 68
            |..|...||.|..||:..|.:....::.:|||:.||:||||||||:|||||:..:.|.::.||||
pombe     8 SSRFKAFKKSETSELQKGLVSQYAYERIDAVKRTIAAMTVGKDVSSLFPDVLKNLATRDITLKKL 72

  Fly    69 VYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDE 133
            |||||:||||:.||:.|:||||||||.|:.||.:||||:||||||||:||..||.:||||.||||
pombe    73 VYLYLINYAKTHPDLCILAVNTFVKDSEEYNPTLRALAIRTMGCIRVNKIIGYLADPLRKALKDE 137

  Fly   134 DPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLV 198
            .|||||.|||||.|:||:........||::||:.|:||.||:||||||.:|:||::.........
pombe   138 HPYVRKAAAVCVVKMYDLDREYCASNGFIEQLQALVSDPNPVVVANAVRSLAEIHDQDPEKGYFN 202

  Fly   199 EMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKV 263
            .:.::| ::|:.||:||.|||::.||:|||.:...|.:||:.:|||:.|:..|||:.||||||||
pombe   203 VVYTMT-DRLMVALSECNEWGRITILNSLARFRTSDIKEAEYVCERVVPQFQHANSGVVLSAVKV 266

  Fly   264 LMKLLEMLSSD-SDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFV 327
            :|..:.:.||| :||   |.||:||||:||||::.|:|||||||||||:||||.|...:.:|||.
pombe   267 IMVHIPLFSSDFTDF---LYKKMAPPLLTLLSTDSEIQYVALRNINLILQKRPSIFDVKTRVFFC 328

  Fly   328 KYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERC 392
            |||||:|:|:|||.|:..||...||.:.:|||:.|.:||:::||::.::.:|..|:||......|
pombe   329 KYNDPLYIKMEKLKIITMLACDENINETISELRAYVSEVELEFVKQTIKCLGDVALKVPSVINDC 393

  Fly   393 VSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYA 457
            :|..|::.:..::|:|||..||::.:.||||.|.:.::..|...::.|.:|.||:||.||:||::
pombe   394 ISIFLEIYELNISYMVQEVTVVMETVLRKYPQKIDLLLPYLSRVIEELGDPRARSSMAWILGEFS 458

  Fly   458 ERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKR-PSDTQELVQHVLSLATQDSDNPDLR 521
            ..|..:.:||...:....||:.|:||.||||||||.|.. ..:.:||||.||:.|...|.|.|||
pombe   459 HVIPTSSKLLSEMISTMADEDLQIQLALLTAVVKLSLMNGKGNDEELVQKVLNYAINQSSNQDLR 523

  Fly   522 DRGFIYWRLLSTDPA-AAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||.|.|.|||:.:.. .|:::|..:||.:|...:|.| .|||.|:|.|::|||||||.|.:|: |
pombe   524 DRAFAYQRLLTPENVRKAQKIVCCEKPSVSYNNNLPE-ALLDALLCEITTLASVYHKLPESFI-G 586

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSA-------- 642
            :|.....::..||....    ..|.|...||:   .:.:.:.:||.:|...|...||
pombe   587 QGKFGADAIQRRAVEEL----NIEEANVHEAI---EKGANVENLLDLDFTDPGATSASDSPITSA 644

  Fly   643 -PAATSNVDLLGGGLDILLG--GPPA-EAAPGGATSLLGDIFGL 682
             |.:.||     ..:|:.:.  .|.. .|.|..|.|...|:.||
pombe   645 QPQSGSN-----SAMDLFMAFEAPSTNNAEPVKARSATDDLLGL 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	255/498 (51%)
		HEAT repeat	51..75	CDD:293787	14/23 (61%)
		HEAT repeat	87..114	CDD:293787	20/26 (77%)
		HEAT repeat	121..151	CDD:293787	22/29 (76%)
		HEAT repeat	160..186	CDD:293787	16/25 (64%)
		HEAT repeat	197..229	CDD:293787	13/31 (42%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	11/28 (39%)
		HEAT repeat	465..495	CDD:293787	15/29 (52%)
		HEAT repeat	506..542	CDD:293787	16/36 (44%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
apl2	NP_595274.1	COG5096	1..677	CDD:227427	311/686 (45%)
		HEAT repeat	57..79	CDD:293787	12/21 (57%)
		HEAT repeat	91..118	CDD:293787	20/26 (77%)
		HEAT repeat	125..155	CDD:293787	22/29 (76%)
		HEAT repeat	164..190	CDD:293787	16/25 (64%)
		HEAT repeat	201..233	CDD:293787	14/32 (44%)