DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AP-1-2beta and apl2

DIOPT Version :9

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_595274.1 Gene:apl2 / 2541255 PomBaseID:SPBC947.02 Length:683 Species:Schizosaccharomyces pombe


Alignment Length:694 Identity:314/694 - (45%)
Similarity:447/694 - (64%) Gaps:33/694 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKL 68
            |..|...||.|..||:..|.:....::.:|||:.||:||||||||:|||||:..:.|.::.||||
pombe     8 SSRFKAFKKSETSELQKGLVSQYAYERIDAVKRTIAAMTVGKDVSSLFPDVLKNLATRDITLKKL 72

  Fly    69 VYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDE 133
            |||||:||||:.||:.|:||||||||.|:.||.:||||:||||||||:||..||.:||||.||||
pombe    73 VYLYLINYAKTHPDLCILAVNTFVKDSEEYNPTLRALAIRTMGCIRVNKIIGYLADPLRKALKDE 137

  Fly   134 DPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLV 198
            .|||||.|||||.|:||:........||::||:.|:||.||:||||||.:|:||::.........
pombe   138 HPYVRKAAAVCVVKMYDLDREYCASNGFIEQLQALVSDPNPVVVANAVRSLAEIHDQDPEKGYFN 202

  Fly   199 EMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKV 263
            .:.::| ::|:.||:||.|||::.||:|||.:...|.:||:.:|||:.|:..|||:.||||||||
pombe   203 VVYTMT-DRLMVALSECNEWGRITILNSLARFRTSDIKEAEYVCERVVPQFQHANSGVVLSAVKV 266

  Fly   264 LMKLLEMLSSD-SDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFV 327
            :|..:.:.||| :||   |.||:||||:||||::.|:|||||||||||:||||.|...:.:|||.
pombe   267 IMVHIPLFSSDFTDF---LYKKMAPPLLTLLSTDSEIQYVALRNINLILQKRPSIFDVKTRVFFC 328

  Fly   328 KYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERC 392
            |||||:|:|:|||.|:..||...||.:.:|||:.|.:||:::||::.::.:|..|:||......|
pombe   329 KYNDPLYIKMEKLKIITMLACDENINETISELRAYVSEVELEFVKQTIKCLGDVALKVPSVINDC 393

  Fly   393 VSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYA 457
            :|..|::.:..::|:|||..||::.:.||||.|.:.::..|...::.|.:|.||:||.||:||::
pombe   394 ISIFLEIYELNISYMVQEVTVVMETVLRKYPQKIDLLLPYLSRVIEELGDPRARSSMAWILGEFS 458

  Fly   458 ERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKR-PSDTQELVQHVLSLATQDSDNPDLR 521
            ..|..:.:||...:....||:.|:||.||||||||.|.. ..:.:||||.||:.|...|.|.|||
pombe   459 HVIPTSSKLLSEMISTMADEDLQIQLALLTAVVKLSLMNGKGNDEELVQKVLNYAINQSSNQDLR 523

  Fly   522 DRGFIYWRLLSTDPA-AAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||.|.|.|||:.:.. .|:::|..:||.:|...:|.| .|||.|:|.|::|||||||.|.:|: |
pombe   524 DRAFAYQRLLTPENVRKAQKIVCCEKPSVSYNNNLPE-ALLDALLCEITTLASVYHKLPESFI-G 586

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSA-------- 642
            :|.....::..||....    ..|.|...||:   .:.:.:.:||.:|...|...||        
pombe   587 QGKFGADAIQRRAVEEL----NIEEANVHEAI---EKGANVENLLDLDFTDPGATSASDSPITSA 644

  Fly   643 -PAATSNVDLLGGGLDILLG--GPPA-EAAPGGATSLLGDIFGL 682
             |.:.||     ..:|:.:.  .|.. .|.|..|.|...|:.||
pombe   645 QPQSGSN-----SAMDLFMAFEAPSTNNAEPVKARSATDDLLGL 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 255/498 (51%)
HEAT repeat 51..75 CDD:293787 14/23 (61%)
HEAT repeat 87..114 CDD:293787 20/26 (77%)
Cnd1 99..269 CDD:289487 90/169 (53%)
HEAT repeat 121..151 CDD:293787 22/29 (76%)
HEAT repeat 160..186 CDD:293787 16/25 (64%)
HEAT repeat 197..229 CDD:293787 13/31 (42%)
HEAT repeat 393..417 CDD:293787 8/23 (35%)
HEAT repeat 429..458 CDD:293787 11/28 (39%)
HEAT repeat 465..495 CDD:293787 15/29 (52%)
HEAT repeat 506..542 CDD:293787 16/36 (44%)
Alpha_adaptinC2 703..799 CDD:197886
B2-adapt-app_C 809..919 CDD:198088
apl2NP_595274.1 COG5096 1..677 CDD:227427 311/686 (45%)
HEAT repeat 57..79 CDD:293787 12/21 (57%)
HEAT repeat 91..118 CDD:293787 20/26 (77%)
Cnd1 103..272 CDD:289487 90/169 (53%)
HEAT repeat 125..155 CDD:293787 22/29 (76%)
HEAT repeat 164..190 CDD:293787 16/25 (64%)
HEAT repeat 201..233 CDD:293787 14/32 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 501 1.000 Domainoid score I55
eggNOG 1 0.900 - - E1_COG5096
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 552 1.000 Inparanoid score I193
OMA 1 1.010 - - QHG53641
OrthoFinder 1 1.000 - - FOG0001621
OrthoInspector 1 1.000 - - oto101031
orthoMCL 1 0.900 - - OOG6_100684
Panther 1 1.100 - - LDO PTHR11134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2029
SonicParanoid 1 1.000 - - X1351
TreeFam 1 0.960 - -
1312.860

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