DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1-2beta and apl1

DIOPT Version :10

Sequence 1:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_596435.1 Gene:apl1 / 2540375 PomBaseID:SPBC2G2.06C Length:677 Species:Schizosaccharomyces pombe


Alignment Length:586 Identity:265/586 - (45%)
Similarity:402/586 - (68%) Gaps:6/586 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TDSKYFTTTKKGEIFELKSELNNDKKEKKK-EAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            :.|.:|::| ..::..:.|..|.||...|: .|:||.||.::.|.|:|:|||.|::.|:::||||
pombe     3 SSSSHFSST-AADLLAVFSSDNKDKSANKRISALKKAIAGISYGYDMSSLFPSVISSMESNNLEL 66

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            |||.||||..||..:|..|..||...:.|...|||:||:||:||:..:.:........:|:.:.|
pombe    67 KKLCYLYLKIYASVKPTEAKRAVKLILNDIYSSNPMIRSLALRTLTSVNIKNFWVAAMDPIVRLL 131

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            .|.|||||||||:.:||||.....|||..|.:|.||::|||.:.:||||::|||..|..:| :|.
pombe   132 DDTDPYVRKTAAIGIAKLYSYDKKMVESSGLIDHLKEMLSDESSVVVANSLAALMNIVNSS-TGF 195

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|.....:: |||:.:|.:|:||.||.|||:|..|.|:...||:|..|||:|.|.|.||||.:.|
pombe   196 KLTFSREIS-NKLVKSLTDCSEWLQVAILDALIFYVPQKPGEAESFAERISPWLQHGNAAVCMGA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPE-VQYVALRNINLIVQKRPDILKHEMKV 324
            |||::.|...:..|:. ......|..|||||||:.:.. .|||.||||.:|:::.|::..:::..
pombe   260 VKVILYLTNYMKDDNR-VKEYFMKTQPPLVTLLARKSSATQYVILRNIQIILEQCPEMFANDIHF 323

  Fly   325 FFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSA 389
            |:..::||||||||||||:.::|:..|:.|:|.|..|||:|:||:.|||:|:.||..|||:|...
pombe   324 FYCNFDDPIYVKLEKLDILTKIADIHNLDQILPEFVEYASEIDVELVRKSVKCIGYLAIKIEERK 388

  Fly   390 ERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIG 454
            ..|:.:|::|:.|||.||:|||::||:||.||||..|:|::..|.||||:||||:|:::::||:|
pombe   389 NDCIDSLIELMNTKVTYVIQEAVIVIRDILRKYPGSYKSLVPILYENLDSLDEPDAKSAVIWILG 453

  Fly   455 EYAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPD 519
            :|||.|:::..||:.:|:||.||..::||.|||||:|:|||:|:...::|.:||...|.:.::||
pombe   454 QYAEEIEDSITLLNDYLKGFFDEPLEIQLTLLTAVIKVFLKKPTAAADMVTNVLQWCTDEVNDPD 518

  Fly   520 LRDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVE 584
            |||||.||.|:||.:|..||:|:||:.|.::..|.:.:|...::|:.:||:|:|:|||||..||:
pombe   519 LRDRGIIYSRMLSANPELAKKVILANMPPVNVGTGMYDPDTTEQLMLNISTLSSIYHKPPNRFVK 583

  Fly   585 G 585
            |
pombe   584 G 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 232/497 (47%)
HEAT repeat 51..75 CDD:293787 15/23 (65%)
HEAT repeat 87..114 CDD:293787 12/26 (46%)
HEAT repeat 121..151 CDD:293787 16/29 (55%)
HEAT repeat 160..186 CDD:293787 14/25 (56%)
HEAT repeat 197..229 CDD:293787 14/31 (45%)
HEAT repeat 393..417 CDD:293787 12/23 (52%)
HEAT repeat 429..458 CDD:293787 14/28 (50%)
HEAT repeat 465..495 CDD:293787 16/29 (55%)
HEAT repeat 506..542 CDD:293787 18/35 (51%)
Alpha_adaptinC2 703..799 CDD:197886
B2-adapt-app_C 809..919 CDD:198088
apl1NP_596435.1 COG5096 11..677 CDD:227427 263/578 (46%)
HEAT repeat 88..116 CDD:293787 12/27 (44%)
HEAT repeat 122..152 CDD:293787 16/29 (55%)
HEAT repeat 161..187 CDD:293787 14/25 (56%)
HEAT repeat 200..227 CDD:293787 12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

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