DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and apb-1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001022937.1	Gene:	apb-1 / 175376	WormBaseID:	WBGene00000160	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	962	Identity:	653/962 - (67%)
Similarity:	760/962 - (79%)	Gaps:	59/962 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:||||||||||||||||||||||||||||||||||||||:||
Worm     1 MTDSKYFTTTKKGEIFELKNELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNVEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            |||||||||||||||||:||||||||||||||.|||||||||||||||||:|||||||:|||:|:
Worm    66 KKLVYLYLMNYAKSQPDLAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVEKITEYLCDPLRRCM 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:|::..:|::|||::.|.|||||:||||||||||||:|:||.    |
Worm   131 KDEDPYVRKTAAVCVAKLHDMNPALVKEQGFVELLNDLLSDANPMVVANAVAALTEMNEQ----Q 191

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .::|:||..:||||||||||||||||||||:||.|:|:||||.|:|||||:|||||||||||||.
Worm   192 TVIEVNSQMVNKLLTALNECTEWGQVFILDALAGYTPRDERETQNICERISPRLAHANAAVVLST 256

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            |||||||::|:.:||||...||||||||:|||||:|||:||||||||||||||||||||.|||||
Worm   257 VKVLMKLIDMMPADSDFITQLTKKLAPPMVTLLSAEPEIQYVALRNINLIVQKRPDILKQEMKVF 321

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            |||||||||||:||||||||||.|:|||||||||||||||||||||||:||||||||||||.|:|
Worm   322 FVKYNDPIYVKMEKLDIMIRLAQQNNIAQVLSELKEYATEVDVDFVRKSVRAIGRCAIKVEASSE 386

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            |||.|||:|||||||||||||:||||||||||||:||||||.|||||||||||||||||:|||||
Worm   387 RCVQTLLELIQTKVNYVVQEAVVVIKDIFRKYPNRYESIISALCENLDTLDEPEARASMIWIIGE 451

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||:|||.|||.||||||||||||||||||...|.|||.||||||||||||||
Worm   452 YAERIDNADELLESFVEGFHDENTQVQLQLLTAVVKLFLKRPGVAQALVQRVLSLATQDSDNPDL 516

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||||||||||.||||||.|||.:|||||||||||||:||::|:|||.:|||||||||:||::.
Worm   517 RDRGFIYWRLLSADPAAAKNVVLTEKPLISEETDLLEPSLLEQLVCHIGTLASVYHKPPSAFIDP 581

  Fly   586 RGAGVRKSLPNRAA--GS-----AAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAP 643
            ..|.:|:..|..||  ||     ::....|.|.:.:...|||:|:.:|.||||:|:|      ||
Worm   582 AKAPLRQINPIPAAKFGSSLLDTSSTPNAARNGSAAAPTVIPSQDQVIADLLSLDLN------AP 640

  Fly   644 AATSNVDLLG---------GGLDIL--LGGPPAEAAP---------------GGATSL------- 675
            ||::|....|         ||||.|  |||.|..|||               |||...
Worm   641 AASANTGAFGGAMSGTTSMGGLDDLLGLGGDPMPAAPTNSASYNPFDGLGGLGGAAPAAPPSQQP 705

  Fly   676 -----LGDIFGLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMT 735
                 |.:|||.||...|.|:..||..||.|.|..|::::|||.||.|::||:||:||:|||.::
Worm   706 ASIGGLAEIFGSGGFGGSSGITYPKELWLDASKAMGMQVEGTFVRRGGKIFMEMTITNRAMQAIS 770

  Fly   736 NFAIQLNKNSFGLVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFA 800
            .||:|.|||||||:|...:..||:.||||...::|..|.|.:|...||.|||||:||:|:.||||
Worm   771 GFALQFNKNSFGLIPVEQVNPAPILPNQSQNYTIACDTTGAVQVTTPLTNLQVAIKNDINAFYFA 835

  Fly   801 CLVHGNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIG-TTDGIASKMTTNNIFTIAKRNV 864
            ..|.....|.||||::||.||..||.||..||.|:||..... ..|.|.:|:..|||.|:|:|.|
Worm   836 TTVPLLAYFREDGQMEKREFLEEWKSIPEQNEQQFTLQNTHNMNADAICTKLQQNNIHTVARRQV 900

  Fly   865 EGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRS-VEVANI--IFAA 913
            :.|.:||.|:|.|||:.||.|||:.......||||||:: :.:|||  :|.|
Worm   901 DNQQLLYHSVKYTNNLNVLSELKVNSQTTSITLSLKSKNLMAIANINEVFQA 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	420/496 (85%)
		HEAT repeat	51..75	CDD:293787	22/23 (96%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..269	CDD:289487	130/169 (77%)
		HEAT repeat	121..151	CDD:293787	25/29 (86%)
		HEAT repeat	160..186	CDD:293787	20/25 (80%)
		HEAT repeat	197..229	CDD:293787	24/31 (77%)
		HEAT repeat	393..417	CDD:293787	20/23 (87%)
		HEAT repeat	429..458	CDD:293787	26/28 (93%)
		HEAT repeat	465..495	CDD:293787	25/29 (86%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	49/95 (52%)
		B2-adapt-app_C	809..919	CDD:198088	52/109 (48%)
apb-1	NP_001022937.1	Adaptin_N	11..531	CDD:279882	445/523 (85%)
		HEAT repeat	51..75	CDD:293787	22/23 (96%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..265	CDD:289487	130/169 (77%)
		HEAT repeat	121..151	CDD:293787	25/29 (86%)
		HEAT repeat	160..186	CDD:293787	20/25 (80%)
		HEAT repeat	197..224	CDD:293787	22/26 (85%)
		HEAT repeat	389..413	CDD:293787	20/23 (87%)
		HEAT repeat	425..454	CDD:293787	26/28 (93%)
		HEAT repeat	461..491	CDD:293787	25/29 (86%)
		HEAT repeat	502..538	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	736..834	CDD:197886	50/97 (52%)
		B2-adapt-app_C	844..955	CDD:198088	52/109 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160168015
Domainoid	1	1.000	877	1.000	Domainoid score	I17
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21972
Inparanoid	1	1.050	1237	1.000	Inparanoid score	I86
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		oto19977
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940