DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and apb-3

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_492170.2	Gene:	apb-3 / 172553	WormBaseID:	WBGene00000163	Length:	945	Species:	Caenorhabditis elegans

Alignment Length:	636	Identity:	186/636 - (29%)
Similarity:	323/636 - (50%)	Gaps:	71/636 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
            :||:.|:::|...|.:|:|::|..:..|||||.||..||..:...|:||||||::||:.||:.|.
Worm    30 DLKAMLDSNKDNLKVDAMKRIINLIAKGKDVSELFAAVVKNVAAKNVELKKLVFVYLVRYAEEQQ 94

  Fly    82 DMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146
            |:|:::::||.:..:|.|.|||..|:|.:..|||..:...:...::..::|..|||||.||..:.
Worm    95 DLALLSISTFQRALKDPNQLIRGSALRVLTSIRVPMVAPIMLLAIKDAVRDMSPYVRKVAAHAIP 159

  Fly   147 KLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTA 211
            |||.:...: |.| .:|.:..||:|...:|:.:||.|..||....      :::.......|...
Worm   160 KLYSLEPEL-EPQ-LVDCIDFLLADRRSLVLGSAVYAFDEICPHR------LDLLHKHFRALCRG 216

  Fly   212 LNECTEWGQVFILDSLANYS----------PKDEREAQSICERITPRLAHANAAVVLSAVKVLMK 266
            |.:..||||:.:::.|..|:          |.| .:...:.....|.|...|.:||::.|::...
Worm   217 LADVDEWGQIVMINMLTRYARHELADPDRGPPD-TDVVLLLNSARPLLQSRNCSVVMAVVQLFYH 280

  Fly   267 LLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRP----------DILKHE 321
            :...        |.|: ::|..||.||....|.|||.|.||..|.::.|          .:....
Worm   281 VAPK--------AQLS-QIARALVRLLRGPRETQYVVLTNIATICERNPVEEGTYAISKTMFDPF 336

  Fly   322 MKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVE 386
            :|.|||:..|...||..||.::..|.:::|:..:|.||:.|....|:  ...||.||||||::|.
Worm   337 LKSFFVRSCDSSLVKKLKLHVLTSLVSEANVHIILRELQTYVHMSDL--ASPAVEAIGRCAVRVG 399

  Fly   387 PSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVW 451
            ..:::|::.|:.||.:....||..|:||||.:.  :.:...:::|.|...:..:...:|||.::|
Worm   400 AVSDQCMTGLVQLISSSDEKVVCSAVVVIKRLL--HASAPLNLLSRLMRLMPNMIAAQARACVIW 462

  Fly   452 IIGEYAERI-DNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDS 515
            ::..:.|:: ..|.:.|....:.|..||..|:|:.|...|||:|.:..|::::||:|..||..|.
Worm   463 LVATHVEQVLHMAPDFLRLIAKKFSTENELVKLEALKLAVKLWLVKRDDSEKIVQYVFQLARFDL 527

  Fly   516 DNPDLRDR-GFIYWRLLSTDPAA--AKEVVLADKP---LIS--EETDLLEPTLLDELICHISSLA 572
             :.|:||| .|:...:.:|:..:  .:|:.::.||   |||  :|.|..:          :.||:
Worm   528 -SYDVRDRCRFLRNLMFNTEILSQHMEEIFMSKKPAPELISSFKERDKFQ----------LGSLS 581

  Fly   573 SVYHKPPTAFVEGRGAGVRKSLPNRAAGSAAGAEQAENAAGSEAMVIPNQE 623
            .|.::..|.:::         ||...|.|:....:.|..|.:|..:..:.|
Worm   582 HVLNQRCTKYID---------LPEFPATSSDSLLRKEAHAPNELKLDDSDE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	159/518 (31%)
		HEAT repeat	51..75	CDD:293787	12/23 (52%)
		HEAT repeat	87..114	CDD:293787	9/26 (35%)
		Cnd1	99..269	CDD:289487	48/179 (27%)
		HEAT repeat	121..151	CDD:293787	11/29 (38%)
		HEAT repeat	160..186	CDD:293787	8/25 (32%)
		HEAT repeat	197..229	CDD:293787	7/31 (23%)
		HEAT repeat	393..417	CDD:293787	9/23 (39%)
		HEAT repeat	429..458	CDD:293787	6/28 (21%)
		HEAT repeat	465..495	CDD:293787	10/29 (34%)
		HEAT repeat	506..542	CDD:293787	11/38 (29%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088
apb-3	NP_492170.2	Adaptin_N	23..546	CDD:279882	165/538 (31%)
		Motor_domain	<35..84	CDD:277568	22/48 (46%)
		HEAT repeat	100..128	CDD:293787	10/27 (37%)
		HEAT repeat	134..162	CDD:293787	9/27 (33%)
		HEAT repeat	171..197	CDD:293787	9/26 (35%)
		AP3B1_C	<740..826	CDD:291462
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920