DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and AP2B1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_011522750.1	Gene:	AP2B1 / 163	HGNCID:	563	Length:	983	Species:	Homo sapiens

Alignment Length:	990	Identity:	692/990 - (69%)
Similarity:	790/990 - (79%)	Gaps:	77/990 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||.|||||||||:||||:||||:|||||||||:||||||||:||||||||||||||||
Human     1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||:|||||||.||||||||||||||||||||||||||||||||
Human    66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.|||||||||.|:||::|||||||||||||||||:| |....
Human   131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISE-SHPNS 194

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|:::|...||||||||||||||||:||||.|:||:|||:|||||||||:||||:|||:||||||
Human   195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.||:|..|||:...|.||||||||||||.||||||||||||||||||||:|||.|:|||
Human   260 VKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
Human   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            |||||||||||||||||||||||||:||||||||||||||:|||||||:||||:|||:|:||:||
Human   390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.||||.||||:||||||:||:||||||.||||||||||||||
Human   455 YAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||..||||||::||||||||||:||||||||||||.||||||||||.|||||
Human   520 RDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLP-----NRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            .....||.||     ..|..|..|...|.|.  .:..|||:|..|:||||::|:..|.  :.|..
Human   585 SHGIHRKHLPIHHGSTDAGDSPVGTTTATNL--EQPQVIPSQGDLLGDLLNLDLGPPV--NVPQV 645

  Fly   646 TS----NVDLLGGGLDILL--------GGPPA----------------EAAPGGATSLLGDIF-- 680
            :|    .|||||||||.||        ||.||                ...|...:|.|.|:|
Human   646 SSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFEL 710

  Fly   681 --GLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNK 743
              |:|.|  ..|...||..||||.|.|||||.|||:.|.|.::|:|..||||:|.||:||||.||
Human   711 STGIGMA--PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNK 773

  Fly   744 NSFGLVPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQ-------------------- 787
            ||||::|::|:.. .||.|||||:||:.|.|.||:.:||||||||
Human   774 NSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVKSKENNWMDTSGRENANIM 838

  Fly   788 ------------VAVKNNIDIFYFACLVHGNVLFAEDGQLDKRVFLNTWKEIPAANELQYTLSGV 840
                        ||||||||:|||:||:..||||.|||:::::|||.|||:||..||||:.:...
Human   839 EKGIQAPFKVRKVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKEC 903

  Fly   841 IGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLSLKSRSVE 905
            ....|.::||:..||::|||||||||||||||||||||.||:|.||::|||||..|||||.|:.|
Human   904 HLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPE 968

  Fly   906 VANIIFAAYEAIIRS 920
            |:..|:..|::|:::
Human   969 VSQYIYQVYDSILKN 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	430/496 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		Cnd1	99..269	CDD:289487	140/169 (83%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	23/29 (79%)
		HEAT repeat	506..542	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	703..799	CDD:197886	62/128 (48%)
		B2-adapt-app_C	809..919	CDD:198088	63/109 (58%)
AP2B1	XP_011522750.1	Adaptin_N	11..534	CDD:307641	454/523 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	392..416	CDD:293787	23/23 (100%)
		HEAT repeat	428..457	CDD:293787	22/28 (79%)
		HEAT repeat	464..494	CDD:293787	23/29 (79%)
		HEAT repeat	505..541	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	731..825	CDD:197886	54/93 (58%)
		B2-adapt-app_C	872..982	CDD:198088	63/109 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	902	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1353	1.000	Inparanoid score	I141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm41048
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	O	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910