DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and AP1B1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001118.3	Gene:	AP1B1 / 162	HGNCID:	554	Length:	949	Species:	Homo sapiens

Alignment Length:	952	Identity:	708/952 - (74%)
Similarity:	802/952 - (84%)	Gaps:	35/952 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
Human     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
Human    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
Human   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
             |:::|..:||||||||||||||||:||||.||||.|||:|||||||||:||||:|||:||||||
Human   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.:||||.|.|:..||.||||||||||||:|||:||||||||||||||||:|||||||||
Human   260 VKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
Human   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            ||||||||||||||||||||||||||||||||||||||:|:|||||||:||||||||:|:||:||
Human   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.|||||||||:||||||:|::||||||.||||||||||||||
Human   455 YAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||:|||||
Human   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEG 584

  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENA-----AGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            ....|.||||.|.| |:..||..|.|     .|.:..|||.|..|:||||::|: .|.:...|.|
Human   585 GRGVVHKSLPPRTA-SSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDL-GPPVSGPPLA 647

  Fly   646 TSN-----VDLLGGGLDILLG------------GPPAEAAPG--GAT--SLLGDIFGL--GGATL 687
            ||:     |||||||||.|:|            .||..|.|.  ||.  |.|.|:|.|  |..||
Human   648 TSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTL 712

  Fly   688 SVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLVPAS 752
            |.....||..||||.|.|||||.|||:|:.|.:.||:.|||||:|.||:||||.|:|||||.||:
Human   713 SGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAA 777

  Fly   753 PMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDGQLD 816
            |:|. |||.|||::|:|:.|.|.|.:.:||||||||||||||||:|||:.|...::||.|||::|
Human   778 PLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMD 842

  Fly   817 KRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTNNIW 881
            :::||.|||:||..||.|:.:.......:..:||:.::||||:|||||||||||||||||||.||
Human   843 RQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIW 907

  Fly   882 VLLELKLQPGNPEAT---LSLKSRSVEVANIIFAAYEAIIRS 920
            ||.||::|||||..|   ||||.|:.||:..::.|||.|:::
Human   908 VLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	438/496 (88%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..269	CDD:289487	142/169 (84%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	24/29 (83%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	63/96 (66%)
		B2-adapt-app_C	809..919	CDD:198088	63/112 (56%)
AP1B1	NP_001118.3	Adaptin_N	11..534	CDD:396262	463/523 (89%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	355..379	CDD:293787	22/23 (96%)
		HEAT repeat	391..419	CDD:293787	27/27 (100%)
		HEAT repeat	427..458	CDD:293787	24/30 (80%)
		HEAT repeat	464..490	CDD:293787	20/25 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		17/41 (41%)
		Alpha_adaptinC2	726..826	CDD:197886	65/99 (66%)
		B2-adapt-app_C	835..948	CDD:198088	63/112 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160538
Domainoid	1	1.000	902	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21972
Inparanoid	1	1.050	1353	1.000	Inparanoid score	I141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm41048
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2029
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800