Protein Alignment AP-1-2beta and Ap2b1

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_542150.1
• Gene: Ap2b1 / 140670
• RGDID: 71048
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 958
• Identity: 692/958 - (72%)
• Similarity: 790/958 - (82%)
• Gaps: 45/958 - (4%)

  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||.|||||||||:||||:||||:|||||||||:||||||||:||||||||||||||||
  Rat     1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLEL 65

  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||:|||||||.||||||||||||||||||||||||||||||||
  Rat    66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195
            ||||||||||||||||||:||:|.|||||||||.|:||::|||||||||||||||||:| |....
  Rat   131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISE-SHPNS 194

  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260
            .|:::|...||||||||||||||||:||||.|:||:|||:|||||||||:||||:|||:||||||
  Rat   195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSA 259

  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325
            ||||||.||:|..|||:...|.||||||||||||.||||||||||||||||||||:|||.|:|||
  Rat   260 VKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVF 324

  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
  Rat   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455
            |||||||||||||||||||||||||:||||||||||||||:|||||||:||||:|||:|:||:||
  Rat   390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGE 454

  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
            ||||||||||||:||||||.||:.||||.||||:||||||:||:||||||.||||||||||||||
  Rat   455 YAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDL 519

  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585
            ||||:||||||||||..||||||::||||||||||:||||||||||||.||||||||||.|||||
  Rat   520 RDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEG 584

  Fly   586 RGAGVRKSLP-----NRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAA 645
            .....||.||     ..|..|..|...|.|.  .:..|||:|..|:||||::|:..|.  :.|..
  Rat   585 SHGIHRKHLPIHHGSTDAGDSPVGTTTATNL--EQPQVIPSQGDLLGDLLNLDLGPPV--NVPQV 645

  Fly   646 TS----NVDLLGGGLDILL--------GGPPA----------------EAAPGGATSLLGDIF-- 680
            :|    .|||||||||.||        ||.||                ...|...:|.|.|:|
  Rat   646 SSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFEL 710

  Fly   681 --GLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNK 743
              |:|.|  ..|...||..||||.|.|||||.|||:.|.|.::|:|..||||:|.||:||||.||
  Rat   711 STGIGMA--PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNK 773

  Fly   744 NSFGLVPASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNV 807
            ||||::|::|:.. .||.|||||:||:.|.|.||:.:||||||||||||||||:|||:||:..||
  Rat   774 NSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNV 838

  Fly   808 LFAEDGQLDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQ 872
            ||.|||:::::|||.|||:||..||||:.:.......|.::||:..||::|||||||||||||||
  Rat   839 LFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQ 903

  Fly   873 SLKLTNNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920
            ||||||.||:|.||::|||||..|||||.|:.||:..|:..|::|:::
  Rat   904 SLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	430/496 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	23/29 (79%)
		HEAT repeat	506..542	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	703..799	CDD:197886	62/96 (65%)
		B2-adapt-app_C	809..919	CDD:198088	63/109 (58%)
Ap2b1	NP_542150.1	Adaptin_N	11..534	CDD:396262	454/523 (87%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	24/26 (92%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	21/25 (84%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	392..416	CDD:293787	23/23 (100%)
		HEAT repeat	428..457	CDD:293787	22/28 (79%)
		HEAT repeat	464..494	CDD:293787	23/29 (79%)
		HEAT repeat	505..541	CDD:293787	31/35 (89%)
		Alpha_adaptinC2	731..831	CDD:197886	64/99 (65%)
		B2-adapt-app_C	840..950	CDD:198088	63/109 (58%)