DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1-2beta and COPB1

DIOPT Version :9

Sequence 1:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001137533.1	Gene:	COPB1 / 1315	HGNCID:	2231	Length:	953	Species:	Homo sapiens

Alignment Length:	1037	Identity:	203/1037 - (19%)
Similarity:	369/1037 - (35%)	Gaps:	298/1037 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNYAKSQP 81
            ||::|.....:.|.||:||||..:..|:.:..|...::. .:...:..:|||:.::.....|:.|
Human    26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTP 90

  Fly    82 D-----MAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTA 141
            |     ..|:..:.:.||.:..|..||...:|.:..::..::.|.|...:|.||:....|||:.|
Human    91 DGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNA 155

  Fly   142 AVCVAKLYDISATMVED-----QGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMN 201
            .:.:..:|.....::.|     ..||...||.....|         |...:..|.|
Human   156 VLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRN---------AFMMLIHADQ--------- 202

  Fly   202 SVTINKLLTALNECTEWGQVF--ILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVKVL 264
                ::.|..|:.|.:..|.|  ||              |.:...:..::.|||.:.....::.:
Human   203 ----DRALDYLSTCIDQVQTFGDIL--------------QLVIVELIYKVCHANPSERARFIRCI 249

  Fly   265 MKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQ-----YVAL------RNINLIVQKRPDIL 318
            ..||:..|      ..:..:.|..||||.|:...::     |:.|      .|:.|||..|...|
Human   250 YNLLQSSS------PAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL 308

  Fly   319 K----HE-------MKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEV------ 366
            |    ||       |.:..|.....:.|:.:.|.:.:.|.:..|:.:::..||:...:.
Human   309 KEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEH 373

  Fly   367 -DVDFVRK-AVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESI 429
             |.|..|: .||.:..|:::....|...:..|::.:.........:.:..:::..:::.|....|
Human   374 EDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLI 438

  Fly   430 ISTLCENLDTLDEPEARASMVWIIGEYAERIDNADELLDSFLEGFQDENAQVQLQL-LTAVVKLF 493
            :..:.|....:...:.....:||:|||.           |..|..|....:::..| ...:|:..
Human   439 VEKMLEVFHAIKSVKIYRGALWILGEYC-----------STKEDIQSVMTEIRRSLGEIPIVESE 492

  Fly   494 LK------RPSD------TQELVQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADK 546
            :|      :|.:      .|:||..:.:.|||.:              |.|:.|...:|    |:
Human   493 IKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA--------------LSSSRPTKKEE----DR 539

  Fly   547 PLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRKSLPNRAAGSAAGAEQAENA 611
            |       .|...|||......:|||:...|....:|                 :....::.:|:
Human   540 P-------PLRGFLLDGDFFVAASLATTLTKIALRYV-----------------ALVQEKKKQNS 580

  Fly   612 AGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGGPPAEAAPGGATSLL 676
            ..:|||:      |:..:|  .:...::|..|....:||.:...|.:|     :|.:|     |:
Human   581 FVAEAML------LMATIL--HLGKSSLPKKPITDDDVDRISLCLKVL-----SECSP-----LM 627

  Fly   677 GDIFGLG-----GATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTN-------- 728
            .|||...     ...||..::..|::.....:.:.:.:|..    :...||.:|..|
Human   628 NDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPD----DPISFMQLTAKNEMNCKEDQ 688

  Fly   729 ---------------KAMQPMTNFAIQLNK-------------------NSFGLVPASPMQAAPL 759
                           :|..|:   |.:|||                   |.:.:|      ...|
Human   689 FQLSLLAAMGNTQRKEAADPL---ASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV------LDVL 744

  Fly   760 PPNQSIEV----SMALGTNGPIQRME---PLN-----------NLQVAVKNNIDIFYFACLVHGN 806
            ..||:.:.    ::.|.|.|.::.:|   ||.           |::||...|..||       ||
Human   745 VVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIF-------GN 802

  Fly   807 VLFAEDGQLDKR-------VFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTT----NNIFTIA 860
            :::...|....|       :.::....|..|.           .||....:|..    .|..|:.
Human   803 IVYDVSGAASDRNCVVLSDIHIDIMDYIQPAT-----------CTDAEFRQMWAEFEWENKVTVN 856

  Fly   861 KRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPEATLS---------LKSRSV----EVANI 909
            ...|:..|.|...||.||         ::...||..||         |.:||:    .:||:
Human   857 TNMVDLNDYLQHILKSTN---------MKCLTPEKALSGYCGFMAANLYARSIFGEDALANV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	105/552 (19%)
		HEAT repeat	51..75	CDD:293787	3/24 (13%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		Cnd1	99..269	CDD:289487	35/176 (20%)
		HEAT repeat	121..151	CDD:293787	9/29 (31%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	7/33 (21%)
		HEAT repeat	393..417	CDD:293787	1/23 (4%)
		HEAT repeat	429..458	CDD:293787	7/28 (25%)
		HEAT repeat	465..495	CDD:293787	5/30 (17%)
		HEAT repeat	506..542	CDD:293787	7/35 (20%)
		Alpha_adaptinC2	703..799	CDD:197886	28/155 (18%)
		B2-adapt-app_C	809..919	CDD:198088	25/125 (20%)
COPB1	NP_001137533.1	Adaptin_N	18..550	CDD:279882	122/601 (20%)
		HEAT 1	96..131		7/34 (21%)
		HEAT 2	132..168		10/35 (29%)
		HEAT repeat	137..161	CDD:293787	7/23 (30%)
		HEAT repeat	173..211	CDD:293787	10/59 (17%)
		HEAT repeat	221..272	CDD:293787	13/70 (19%)
		HEAT 3	240..276		9/41 (22%)
		HEAT 4	277..314		9/36 (25%)
		HEAT repeat	280..307	CDD:293787	7/26 (27%)
		HEAT 5	316..353		5/36 (14%)
		HEAT repeat	318..342	CDD:293787	3/23 (13%)
		HEAT 6	396..433		2/36 (6%)
		Coatamer_beta_C	667..807	CDD:285019	29/159 (18%)
		Coatomer_b_Cpla	816..944	CDD:291472	23/114 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810