Protein Alignment AP-1-2beta and Ap3b1

DIOPT Version :10

• Sequence 1: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: XP_006517586.1
• Gene: Ap3b1 / 11774
• MGIID: 1333879
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1129
• Identity: 278/1129 - (24%)
• Similarity: 457/1129 - (40%)
• Gaps: 276/1129 - (24%)

  Fly    11 KKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMN 75
            ||.|  :||..|.::|...|.:|:|:::..:..||:.|.|||.||..:.:.|:|:|||||:||:.
Mouse    42 KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVR 104

  Fly    76 YAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKT 140
            ||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..|||||.
Mouse   105 YAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKN 169

  Fly   141 AAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTI 205
            ||..:.|||.:...  :.:..::.::.||.|.:.:|..:.|.|..|:   ......|:..|   .
Mouse   170 AAHAIQKLYSLDPE--QKEMLIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHRN---Y 226

  Fly   206 NKLLTALNECTEWGQVFILDSLANY------SP--------------------KDEREAQS---- 240
            .||...|.:..|||||.|:..|..|      ||                    ::|:|..|
Mouse   227 RKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWREDGGLEDNEKNFYESEEEEEEKEKSSRKKS 291

  Fly   241 ---------ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSE 296
                     :.....|.|...|||||::..::...:     |.......::|.    ||.||.|.
Mouse   292 YAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHI-----SPKSEAGVISKS----LVRLLRSN 347

  Fly   297 PEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKE 361
            .||||:.|:||..:..:|..:.:..:|.|:|:..||..:|..||:|:..|||::||:.:|.|.:.
Mouse   348 REVQYIVLQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQT 412

  Fly   362 YATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKY 426
            |....|..|....::.|||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|.::
Mouse   413 YVRSQDKQFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQH 477

  Fly   427 ESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVV 490
            ..||..:.:.||::..|.||||::|:|||..||:.. |.::|....:.|..|:..|:||:|....
Mouse   478 GEIIRHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAA 542

  Fly   491 KLFLKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLADKPLI 549
            ||:|.....|:.|.|::|:|...| .|.|:||| .||...::..:.:.     ||::.||.||
Mouse   543 KLYLTNSKQTKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAPKP-- 604

  Fly   550 SEETDLLEPTLLDE------LICHISSL-ASVY-------------------------------- 575
               ..|||....|.      .:.|..:: ||.|
Mouse   605 ---APLLESPFKDRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAKEWTPLGK 666

  Fly   576 ---HKPPTAFV-----------------------------------EGRGA-----GVRKSLPNR 597
               .||...|.                                   .|.|:     |...|..:.
Mouse   667 TKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSEDS 731

  Fly   598 AA------GSAAGAEQA----------------------ENAAGSEAMVIPNQESLIGDLLSMDI 634
            ::      ||.|.||:.                      ||:..||:.  ..:.|.:.|..|...
Mouse   732 SSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNENSKASESS--SEESSSMEDSSSESE 794

  Fly   635 NAPAMPSAPA------------------ATSNVDLLGGGLDIL--LGGPPAEAAPGGATSLLGDI 679
            :.....|.||                  .:.:|.||  .||..  :..|.|...|..:.||:.|:
Mouse   795 SESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLL--DLDDFNPVSTPVALPTPALSPSLIADL 857

  Fly   680 FGLGGATLSVGVQIPKVTWLPAE--------KGKGLEIQGTFSRR-----NGEVFMDMTLTNKAM 731
            .||..:|.|..:.:....::|.:        .||||.....|.|:     :..|.:.:||||.:.
Mouse   858 EGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQPCIFSDKMVSVQITLTNTSD 922

  Fly   732 QPMTNFAIQLNKNSFGLVPASPMQA----APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKN 792
            :.:.|..|    ...||.....|.|    ..|.|..|:.||:.:......|..    :.|:..|:
Mouse   923 RKIENIHI----GGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCDSTQTA----SFQLCTKD 979

  Fly   793 NIDIFYF------------------------ACLVHGNVLFAEDGQLDKRVFLNTWKEIPAANEL 833
              |.|..                        |||...:|..|..|.|   ..:|.......|...
Mouse   980 --DCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGTL---TGMNETSATLIAAPQ 1039

  Fly   834 QYTLSGVIGTTDGIAS----KMTTNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGNPE 894
            .:|.|.::.....:|:    ..:.:|:...|.|.|....::            |:.::|:.|: .
Mouse  1040 NFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLM------------LVTVELKEGS-T 1091

  Fly   895 ATLSLKSRSVEVANIIFAAYEAII 918
            |.|.:.:....:.:::....:.::
Mouse  1092 AQLIINTEKTVIGSVLLRELKPVL 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	168/537 (31%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		HEAT repeat	121..151	CDD:293787	11/29 (38%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	12/31 (39%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	13/28 (46%)
		HEAT repeat	465..495	CDD:293787	9/29 (31%)
		HEAT repeat	506..542	CDD:293787	12/41 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	27/104 (26%)
		B2-adapt-app_C	809..919	CDD:198088	17/114 (15%)
Ap3b1	XP_006517586.1	Adaptin_N	46..582	CDD:396262	175/553 (32%)
		HEAT repeat	116..144	CDD:293787	11/27 (41%)
		HEAT repeat	150..180	CDD:293787	11/29 (38%)
		HEAT repeat	188..213	CDD:293787	6/24 (25%)
		SEEEED	<734..792	CDD:434218	11/59 (19%)
		AP3B1_C	824..969	CDD:464319	38/150 (25%)