| Sequence 1: | NP_523415.1 | Gene: | AP-1-2beta / 32987 | FlyBaseID: | FBgn0010380 | Length: | 921 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001240781.1 | Gene: | AP4B1 / 10717 | HGNCID: | 572 | Length: | 739 | Species: | Homo sapiens |
| Alignment Length: | 644 | Identity: | 191/644 - (29%) |
|---|---|---|---|
| Similarity: | 336/644 - (52%) | Gaps: | 67/644 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 17 ELKSELNND----KKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYA 77
Fly 78 KSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAA 142
Fly 143 VCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINK 207
Fly 208 -----LLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVK---VL 264
Fly 265 MKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEP-EVQYVALRNINLIVQKRPDILKHEMKVFFVK 328
Fly 329 YNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCV 393
Fly 394 STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTL--CENLDTLDEPEARASMVWIIGEY 456
Fly 457 AERIDNADELLDSFLEGFQDEN-AQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520
Fly 521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTL----------LDELICHISSLASVY 575
Fly 576 HKPPTAFVEGRGAGVRK---SLPNRAAGSAAG-------AEQAENAAGSEA-MVIPNQE 623 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AP-1-2beta | NP_523415.1 | Adaptin_N | 38..535 | CDD:279882 | 164/508 (32%) |
| HEAT repeat | 51..75 | CDD:293787 | 10/23 (43%) | ||
| HEAT repeat | 87..114 | CDD:293787 | 14/26 (54%) | ||
| Cnd1 | 99..269 | CDD:289487 | 55/177 (31%) | ||
| HEAT repeat | 121..151 | CDD:293787 | 10/29 (34%) | ||
| HEAT repeat | 160..186 | CDD:293787 | 9/25 (36%) | ||
| HEAT repeat | 197..229 | CDD:293787 | 12/36 (33%) | ||
| HEAT repeat | 393..417 | CDD:293787 | 3/23 (13%) | ||
| HEAT repeat | 429..458 | CDD:293787 | 6/30 (20%) | ||
| HEAT repeat | 465..495 | CDD:293787 | 11/30 (37%) | ||
| HEAT repeat | 506..542 | CDD:293787 | 10/35 (29%) | ||
| Alpha_adaptinC2 | 703..799 | CDD:197886 | |||
| B2-adapt-app_C | 809..919 | CDD:198088 | |||
| AP4B1 | NP_001240781.1 | Adaptin_N | 9..525 | CDD:331138 | 170/532 (32%) |
| HEAT repeat | 86..113 | CDD:293787 | 14/26 (54%) | ||
| HEAT repeat | 120..150 | CDD:293787 | 10/29 (34%) | ||
| HEAT repeat | 159..185 | CDD:293787 | 9/25 (36%) | ||
| HEAT repeat | 198..222 | CDD:293787 | 6/23 (26%) | ||
| Hinge. /evidence=ECO:0000305|PubMed:26542808 | 534..600 | 14/75 (19%) | |||
| Ear, mediates interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808 | 601..739 | 6/25 (24%) | |||
| B2-adapt-app_C | 621..730 | CDD:312560 | 2/5 (40%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5096 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D323029at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||